Clinical and Pathological Spectrum of Acromegaly: Distinguishing GH-PitNETs, Mammosomatotrophs and Mixed Tumors [0.03%]
肢端肥大症的临床和病理谱系：生长激素垂体神经内分泌肿瘤、乳腺素素细胞瘤和混合型肿瘤的区别
Rebeca Martínez-Hernández,Fernando F Méndez-García,Ana Serrano-Somavilla et al.
Rebeca Martínez-Hernández et al.
Introduction: Acromegaly is a rare disease usually caused by a pituitary neuroendocrine tumor (PitNET) that produces growth hormone (GH-PitNET). Tumors secreting GH and prolactin (GH&PRL-PitNETs), contribute up to 30% to ...
Maternal Thyroid Hormone Imbalance and Risk of Autism Spectrum Disorder [0.03%]
母体甲状腺激素失衡与自闭症谱系障碍发病风险的关联研究
Leena Elbedour,May Weinberg,Gal Meiri et al.
Leena Elbedour et al.
Context: Maternal thyroid hormones are essential for fetal neurodevelopment. Gestational thyroid imbalance has been associated with atypical neurodevelopment, including increased risk of autism spectrum disorder (ASD). ...
The role of Obstructive Sleep Apnea and CPAP therapy in the functional hypogonadism of male patients with severe obesity [0.03%]
阻塞性睡眠呼吸暂停和持续气道正压通气在重度肥胖男性功能性低睾酮血症中的作用
Alessandro Amodeo,Biagio Cangiano,Nicoletta Del Duca et al.
Alessandro Amodeo et al.
Background: Only a few studies have reported a correlation between severe Obstructive Sleep Apnea Syndrome (OSAS) and hypogonadism in patients with obesity, regardless of body mass index (BMI). However, longitudinal studi...
Parity as a Risk Factor for Differentiated Thyroid Carcinoma- A Population-Based Study [0.03%]
性别差异作为分化型甲状腺癌的风险因素-一项基于人群的研究
Rotem Dan,Nave Paran,Nuphar Vinegrad et al.
Rotem Dan et al.
Context: Female sex is a risk factor for differentiated thyroid carcinoma (DTC), potentially due to reproductive influences. However, data on the association between parity and DTC risk remain inconsistent. ...
Tumor-infiltrating T Lymphocytes Recognize Thyroid-specific and Neo-antigens in Follicular Cell-derived Thyroid Cancers [0.03%]
滤泡细胞来源的甲状腺癌肿瘤浸润性T淋巴细胞识别甲状腺特异性及新抗原
Breaunna Garza,Jacob Calhoun,Paul Norman et al.
Breaunna Garza et al.
Background: Thyroid cancers are among the growing list of cancer types that are resistant to immune-checkpoint inhibitor (ICI) monotherapy. While T cell infiltration is common in follicular cell-derived thyroid cancers, t...
RNF216 variants found in patients with dementia, hypogonadotropic hypogonadism and severe ataxia deregulate autophagy [0.03%]
RNF216变异导致痴呆、性发育不良和严重共济失调并调节自噬功能異常
Jacques Young,Inès Abdennebi,Marion Le Saëc et al.
Jacques Young et al.
Context: Hypogonadotropic hypogonadism (HH) with severe ataxia, impotence and dementia has been reported in a handful of patients carrying RNF216 gene variants. However, the underlying molecular mechanism explaining this ...
Jerzy Beltowski
Jerzy Beltowski
Real-world osilodrostat effectiveness and safety in non-pituitary Cushing syndrome [0.03%]
库欣综合征的柳螺铜肽疗效和安全性研究
Antoine Tabarin,Jérôme Bertherat,Bénédicte Decoudier et al.
Antoine Tabarin et al.
Context: Osilodrostat's clinical development program mostly enrolled Cushing disease patients. Data in non-pituitary Cushing syndrome (CS) are limited. Ob...
Impact of Subtype Variability on Clinical Features in Papillary Thyroid Cancer [0.03%]
乳头状甲状腺癌亚型差异对临床特征的影响
Jun Sung Lee,Nam Kyung Kim,Ho Jung Jeong et al.
Jun Sung Lee et al.
Context: Thyroid cancer comprises multiple subtypes and is broadly classified as aggressive or nonaggressive. While many studies have analyzed the clinical features of aggressive and nonaggressive subtypes, to the best of...