An NMR-based metabolic signature to identify clinically significant prostate cancer in patients undergoing biopsy [0.03%]
基于代谢标志物的核磁共振用于活检患者具有临床意义前列腺癌的诊断
Michael Ladurner,Tobias Ameismeier,Helmut Klocker et al.
Michael Ladurner et al.
Context: Despite clinical suspicion of prostate cancer (PCa), 20-25% of patients exhibit a tumor-negative biopsy result. Objective: To ...
Impaired 11β-hydroxysteroid dehydrogenase type 2 activity in kidney disease disrupts 11-oxygenated androgen biosynthesis [0.03%]
肾脏疾病中受损的II型11β-羟基类固醇脱氢酶活性会破坏11-氧代雄性激素的合成
Maria Tomkins,Tara McDonnell,Leanne Cussen et al.
Maria Tomkins et al.
Context: 11-oxygenated androgens are a group of adrenal-derived steroids that require peripheral activation. In vitro data highlight a putative role for 11β-hydroxysteroid dehydrogenase type 2 (HSD11B2) in 11-oxygenated ...
Low-level mosaic GCK mutations in children with diazoxide-unresponsive congenital hyperinsulinism [0.03%]
低水平的GCK突变导致降糖素释放激素不受二氮嗪控制的儿童原发性高胰岛素性低血糖症
Kara E Boodhansingh,Katherine Lord,N Scott Adzick et al.
Kara E Boodhansingh et al.
Context: Some children with diazoxide-unresponsive congenital hyperinsulinism (HI) lack any detectable disease-causing mutation in peripheral blood DNA. O...
ACTH stimulation and oral salt loading tests detect biochemical outcome early after primary aldosteronism surgery [0.03%]
原发性醛固酮增多症手术后早期皮质醇刺激和口服盐负荷试验可及时发现生化转归情况
Yuto Ishida,Kazuki Nakai,Kazuki Watanabe et al.
Yuto Ishida et al.
Background: In primary aldosteronism (PA), the biochemical outcomes of the Primary Aldosteronism Surgical Outcome study are used to assess aldosterone hypersecretion 6-12 months after surgery. However, few studies have in...
Systematic analysis and network mapping of disease associations in autoimmune polyglandular syndrome [0.03%]
自身免疫性多腺体综合征的疾病关联的系统分析和网络构建
Greta Pham-Dobor,Peter Kaltenecker,Viktoria Temesfoi et al.
Greta Pham-Dobor et al.
Background: The purpose of our work was to provide a data-driven perspective to APS, a complex autoimmune disorder, supplementing traditional clinical observations. ...
Octreotide subcutaneous depot for acromegaly: A randomized, double-blind, placebo-controlled phase 3 trial, ACROINNOVA 1 [0.03%]
长效奥曲肽治疗肢端肥大症的III期临床试验（ACROINNOVA 1）：一项随机、双盲、安慰剂对照研究
Diego Ferone,Pamela Freda,Laurence Katznelson et al.
Diego Ferone et al.
Context: Acromegaly, characterized by excessive growth hormone (GH) and insulin-like growth factor-1 (IGF-1), impacts quality of life (QoL) and mortality. Standard of care (SoC; octreotide long-acting repeatable or lanreo...
Johanna M Joensuu,Olavi Ylikorkala,Minttu Venetkoski et al.
Johanna M Joensuu et al.
Context: Women with a history of pre-eclamptic pregnancy are predisposed to later occlusive vascular diseases. Objective: We compared t...
The Effects of the AGE Inhibitor Pyridoxamine on Bone in Older Women with Type 2 Diabetes: a Randomized Clinical Trial [0.03%]
AGE抑制剂吡哆醇对老年2型糖尿病女性骨代谢的影响：随机临床试验
Aiden V Brossfield,Donald J McMahon,Jason Fernando et al.
Aiden V Brossfield et al.
Context: Type 2 diabetes (T2D) patients have reduced bone turnover and increased fractures. Advanced glycation endproducts (AGEs) impair osteoblasts and are implicated in diabetic fractures. Pyridoxamine (PM) is a vitamin...
Efficacy and Safety of TransCon PTH in Adults with Hypoparathyroidism: 52-Week Results From the Phase 3 PaTHway Trial [0.03%]
针对特发性低甲状旁腺素血症成人患者的疗效和安全性：来自PATHway III期试验的52周研究结果
Bart L Clarke,Aliya A Khan,Mishaela R Rubin et al.
Bart L Clarke et al.
Context: Conventional therapy for hypoparathyroidism aims to alleviate symptoms of hypocalcemia but does not address insufficient parathyroid hormone (PTH) levels. ...
Associations of Serum Testosterone and Sex Hormone-Binding Globulin with Incident Fractures in Middle-Aged to Older Men [0.03%]
血清睾丸激素与性激素结合球蛋白与中老年男性骨折的相关性
Louise Grahnemo,Ross J Marriott,Kevin Murray et al.
Louise Grahnemo et al.
Context: As men age, circulating testosterone (T) decreases, circulating sex-hormone binding globulin (SHBG) increases, and risk of fracture increases. It is unclear if circulating T, independently of comorbidities, is as...