Prediabetes subgroups, type 2 diabetes risk, and differential effects of preventive interventions [0.03%]
糖前状态亚组、2型糖尿病风险及预防干预的差异效应
Jeanette M Stafford,Ramon Casanova,Byron C Jaeger et al.
Jeanette M Stafford et al.
Objective: Prior studies have subclassified type 2 diabetes using statistical clustering approaches with clinical data, but few have subclassified prediabetes and assessed effects of preventive interventions. Our objectiv...
The relationships between MASLD, extrahepatic multimorbidity and all-cause mortality in UK Biobank cohort [0.03%]
英国生物样本库队列中MASLD与额外肝脏多发病和全因死亡率之间关系的关联性研究
Qi Feng,Chioma N Izzi-Engbeaya,Andrea D Branch et al.
Qi Feng et al.
Background & aims: This study aimed to estimate the impact of metabolic dysfunction-associated steatotic liver disease (MASLD), with and without multimorbidity, on all-cause mortality. ...
Glucose Parameters, Inflammation Markers, and Gut Microbiota Changes of Gut Microbiome-Targeted Therapies in Type 2 Diabetes Mellitus: a Systematic Review and Meta-Analysis of Randomized Controlled Trials [0.03%]
肠道微生物群靶向治疗对2型糖尿病患者血糖参数、炎症标志物和肠道菌群的影响：系统综述和meta分析
Xin Zhou,Wenbin Zheng,Wen Kong et al.
Xin Zhou et al.
Purpose: This meta-analysis aims to summarize the effects of gut microbiome-targeted therapies (MTTs) on glucometabolic, inflammatory factors and gut microbiota in patients with type 2 diabetes mellitus (T2DM). ...
Efficacy of GLP-1-based Therapies on Metabolic Dysfunction-Associated Steatotic Liver Disease and Metabolic Dysfunction-Associated Steatohepatitis: A Systematic Review and Meta-Analysis [0.03%]
基于GLP-1的疗法对代谢紊乱相关脂肪肝病和代谢紊乱相关非酒精性脂肪性肝炎疗效的系统评价和meta分析
Yahao Wang,Yue Zhou,Zhihong Wang et al.
Yahao Wang et al.
Objective: New therapies are urgently needed for the treatment of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH). We conducted this systematic ...
Investigating the Origins of Biochemical Dysregulation in Trisomy 21 Pregnancy [0.03%]
探究21三体妊娠生化异常的起源
Angelika Buczyńska,Iwona Sidorkiewicz,Adam Jacek Krętowski et al.
Angelika Buczyńska et al.
Background & aims: Genetic profiling of trisomy 21 (T21) shows disruptions in energy homeostasis and oxidative stress pathways. This study aimed to evaluate oxidative and metabolic dysregulation in T21 pregnancies, aiming...
Inflammation-associated lipidomic signatures prior to carotid artery atherosclerosis in people living with HIV [0.03%]
与HIV阳性人群颈动脉粥样硬化前相关的脂质组学特征炎症相关性
Yingying Ding,Xiaoxiao Chen,Weiwei Shen et al.
Yingying Ding et al.
Objectives: Lipid metabolism plays an important role in HIV-associated atherosclerosis. However, the interplay between lipid metabolism, uncontrolled inflammation and subclinical carotid atherosclerosis (SCA) in HIV infec...
Cardiomyopathy in patients with acromegaly - not truly a concern anymore? [0.03%]
肢端肥大症患者的心肌病-不再是一个真正的担忧？
Peter Wolf,Luigi Maione,Peter Kamenický et al.
Peter Wolf et al.
Acromegaly is associated with increased mortality rates if not adequately treated. Cardiovascular and metabolic comorbidities are highly prevalent and have long been considered the main cause of death among patients with acromegaly. However...
Incretin Receptor Agonism, Fat-free Mass, and Cardiorespiratory Fitness: A Narrative Review [0.03%]
肠降糖激素受体激动作用、无脂肪质量和心肺运动能力：综述性文章
Zhenqi Liu,Nathan R Weeldreyer,Siddhartha S Angadi
Zhenqi Liu
Context: Individuals with obesity often exhibit low muscle quality and are at risk of reduced muscle mass and diminished cardiorespiratory fitness (CRF). Glucagon-like peptide 1 (GLP-1) receptor agonists (GLP-1RA) and dua...
Nick Tran,Thach S Tran,Tuan V Nguyen
Nick Tran
Context: A P-value and statistical significance, conventionally considered for assessing an intervention's effectiveness are usually misused and misinterpreted. ...
TSH Receptor Antibody Test Utilization Patterns from a National Reference Laboratory: TRAb, TSI, or Both? [0.03%]
全国参考实验室的促甲状腺激素受体抗体检测利用模式：TRAb、TSI或两者都需要？
Heather A Nelson,Kelly Doyle,Joely A Straseski
Heather A Nelson
Background: There are currently two classes of thyroid stimulating hormone receptor (TSHR) antibody assays, namely TSHR antibody (TRAb) assays and thyroid stimulating immunoglobulin (TSI) assays. Clinical guidelines do no...