Adipose Tissue Dysfunction and Energy Balance Paradigms in People Living With HIV [0.03%]
人类免疫缺陷病毒(HIV)感染者中的脂肪组织功能障碍和能量平衡模型
Claudia E Ramirez Bustamante,Neeti Agarwal,Aaron R Cox et al.
Claudia E Ramirez Bustamante et al.
Over the past 4 decades, the clinical care of people living with HIV (PLWH) evolved from treatment of acute opportunistic infections to the management of chronic, noncommunicable comorbidities. Concurrently, our understanding of adipose tis...
Bijal Patel,Kanyada Koysombat,Edouard G Mills et al.
Bijal Patel et al.
Kisspeptin (KP) and neurokinin B (NKB) are neuropeptides that govern the reproductive endocrine axis through regulating hypothalamic gonadotropin-releasing hormone (GnRH) neuronal activity and pulsatile GnRH secretion. Their critical role i...
Yuhu Zhao,Xiaole Peng,Qing Wang et al.
Yuhu Zhao et al.
The homeostasis of bone microenvironment is the foundation of bone health and comprises 2 concerted events: bone formation by osteoblasts and bone resorption by osteoclasts. In the early 21st century, leptin, an adipocytes-derived hormone, ...
Vladimir Saenko,Norisato Mitsutake
Vladimir Saenko
Radiation is an environmental factor that elevates the risk of developing thyroid cancer. Actual and possible scenarios of exposures to external and internal radiation are multiple and diverse. This article reviews radiation doses to the th...
Gregory L Hundemer,Alexander A Leung,Gregory A Kline et al.
Gregory L Hundemer et al.
Primary aldosteronism (PA) is an endocrinopathy characterized by dysregulated aldosterone production that occurs despite suppression of renin and angiotensin II, and that is non-suppressible by volume and sodium loading. The effectiveness o...
The Hypothalamus-pituitary-adrenocortical Response to Critical Illness: A Concept in Need of Revision [0.03%]
重症情况下下丘脑-垂体-肾上腺皮质轴反应的概念亟需修正
Lies Langouche,Arno Téblick,Jan Gunst et al.
Lies Langouche et al.
Based on insights obtained during the past decade, the classical concept of an activated hypothalamus-pituitary-adrenocortical axis in response to critical illness is in need of revision. After a brief central hypothalamus-pituitary-adrenoc...
Epigenetic Dysregulation in Endometriosis: Implications for Pathophysiology and Therapeutics [0.03%]
子宫内膜异位症的表观遗传调控紊乱：对病生理及治疗的意义
Ryan M Marquardt,Dinh Nam Tran,Bruce A Lessey et al.
Ryan M Marquardt et al.
Endometriosis is a prevalent gynecological condition associated with pelvic pain and infertility. Despite more than a century of research, the etiology of endometriosis still eludes scientific consensus. This lack of clarity has resulted in...
Nicotinamide Adenine Dinucleotide in Aging Biology: Potential Applications and Many Unknowns [0.03%]
烟酰胺腺嘌呤二核苷酸与衰老生物学：潜在应用及诸多未解之谜
Shalender Bhasin,Douglas Seals,Marie Migaud et al.
Shalender Bhasin et al.
Recent research has unveiled an expansive role of NAD+ in cellular energy generation, redox reactions, and as a substrate or cosubstrate in signaling pathways that regulate health span and aging. This review provides a critical appraisal of...
Cheryl A Conover,Claus Oxvig
Cheryl A Conover
Pregnancy-associated plasma protein-A (PAPP-A) was first identified in the early 1970s as a placental protein of unknown function, present at high concentrations in the circulation of pregnant women. In the mid-to-late 1990s, PAPP-A was dis...
Reevaluating the Role of Progesterone in Ovarian Cancer: Is Progesterone Always Protective? [0.03%]
重新评估孕酮在卵巢癌中的作用：孕酮总是具有保护作用吗？
Laura J Mauro,Angela Spartz,Julia R Austin et al.
Laura J Mauro et al.
Ovarian cancer (OC) represents a collection of rare but lethal gynecologic cancers where the difficulty of early detection due to an often-subtle range of abdominal symptoms contributes to high fatality rates. With the exception of BRCA1/2 ...