Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes? [0.03%]
假说：果糖摄入过多和尿酸是否会导致2型糖尿病？
Richard J Johnson,Santos E Perez-Pozo,Yuri Y Sautin et al.
Richard J Johnson et al.
We propose that excessive fructose intake (>50 g/d) may be one of the underlying etiologies of metabolic syndrome and type 2 diabetes. The primary sources of fructose are sugar (sucrose) and high fructose corn syrup. First, fructose intake ...
Growth hormone and insulin-like growth factor-I in the transition from normal mammary development to preneoplastic mammary lesions [0.03%]
生长激素和胰岛素样生长因子-I在正常乳腺发育向癌前乳腺病变转变过程中的作用
David L Kleinberg,Teresa L Wood,Priscilla A Furth et al.
David L Kleinberg et al.
Adult female mammary development starts at puberty and is controlled by tightly regulated cross-talk between a group of hormones and growth factors. Although estrogen is the initial driving force and is joined by luteal phase progesterone, ...
Bisphenol-A and the great divide: a review of controversies in the field of endocrine disruption [0.03%]
双酚A与分歧领域：内分泌干扰领域的争议综述
Laura N Vandenberg,Maricel V Maffini,Carlos Sonnenschein et al.
Laura N Vandenberg et al.
In 1991, a group of 21 scientists gathered at the Wingspread Conference Center to discuss evidence of developmental alterations observed in wildlife populations after chemical exposures. There, the term "endocrine disruptor" was agreed upon...
Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review [0.03%]
二甲双胍治疗多囊卵巢综合征的循证和潜在益处——全面综述
Stefano Palomba,Angela Falbo,Fulvio Zullo et al.
Stefano Palomba et al.
Metformin is an insulin sensitizer widely used for the treatment of patients affected by type 2 diabetes mellitus. Because many women with polycystic ovary syndrome (PCOS) are insulin resistant, metformin was introduced in clinical practice...
E. Brad Thompson
E. Brad Thompson
Skin is the largest organ of the human body and undergoes both intrinsic (chronological) and extrinsic aging. While intrinsic skin aging is driven by genetic and epigenetic factors, extrinsic aging is mediated by external threats such as UV...
Glucose-Dependent Insulinotropic Polypeptide in Incretin Physiology: Role in Health and Disease [0.03%]
葡萄糖依赖性胰多肽在增效生理中的作用：在健康和疾病中的影响
Glucose-dependent insulinotropic polypeptide (GIP) is a 42-amino acid hormone that is synthesized and released from upper intestinal enteroendocrine K-cells in response to the ingestion of glucose or fat. The structure of GIP places it in t...