Harald Staiger,Fausto Machicao,Andreas Fritsche et al.
Harald Staiger et al.
Type 2 diabetes mellitus is a complex metabolic disease that is caused by insulin resistance and beta-cell dysfunction. Furthermore, type 2 diabetes has an evident genetic component and represents a polygenic disease. During the last decade...
Molecular mechanisms underlying the activation of mammalian primordial follicles [0.03%]
哺乳动物原始卵泡激活的分子机制
Deepak Adhikari,Kui Liu
Deepak Adhikari
In humans and other mammalian species, the pool of resting primordial follicles serves as the source of developing follicles and fertilizable ova for the entire length of female reproductive life. One question that has intrigued biologists ...
F J Broekmans,M R Soules,B C Fauser
F J Broekmans
Menopause is the final step in the process referred to as ovarian ageing. The age related decrease in follicle numbers dictates the onset of cycle irregularity and the final cessation of menses. The parallel decay in oocyte quality contribu...
Claes Ohlsson,Subburaman Mohan,Klara Sjögren et al.
Claes Ohlsson et al.
IGF-I is expressed in virtually every tissue of the body, but with much higher expression in the liver than in any other tissue. Studies using mice with liver-specific IGF-I knockout have demonstrated that liver-derived IGF-I, constituting ...
Endocrine-disrupting chemicals: an Endocrine Society scientific statement [0.03%]
内分泌干扰物：《内分泌协会科学声明》
Evanthia Diamanti-Kandarakis,Jean-Pierre Bourguignon,Linda C Giudice et al.
Evanthia Diamanti-Kandarakis et al.
There is growing interest in the possible health threat posed by endocrine-disrupting chemicals (EDCs), which are substances in our environment, food, and consumer products that interfere with hormone biosynthesis, metabolism, or action res...
Unraveling insulin-like growth factor binding protein-3 actions in human disease [0.03%]
解开胰岛素样生长因子结合蛋白-3在人类疾病中的作用
Sherryline Jogie-Brahim,David Feldman,Youngman Oh
Sherryline Jogie-Brahim
The IGF system plays critical roles in somatic growth in an endocrine fashion (somatomedin hypothesis) as well as proliferation and differentiation of normal and malignant cells in a paracrine/autocrine fashion. IGFBP-3 is known to modulate...
Iodine deficiency [0.03%]
碘缺乏病
Michael B Zimmermann
Michael B Zimmermann
Iodine deficiency has multiple adverse effects in humans, termed iodine deficiency disorders, due to inadequate thyroid hormone production. Globally, it is estimated that 2 billion individuals have an insufficient iodine intake, and South A...
R Paul Robertson,Linda C Giudice
R Paul Robertson