Targeting Cell Senescence and Senolytics: Novel Interventions for Age-Related Endocrine Dysfunction [0.03%]
细胞衰老和衰老清除：治疗年龄相关性内分泌功能障碍的新方法
Masayoshi Suda,Karl H Paul,Utkarsh Tripathi et al.
Masayoshi Suda et al.
Multiple changes occur in hormonal regulation with aging and across various endocrine organs. These changes are associated with multiple age-related disorders and diseases. A better understanding of responsible underling biological mechanis...
Relative Energy Deficiency in sport (REDs): Endocrine manifestations, pathophysiology and treatments [0.03%]
运动中相对能量不足（REDs）：内分泌表现、病理生理学和治疗
Angeliki M Angelidi,Konstantinos Stefanakis,Sharon H Chou et al.
Angeliki M Angelidi et al.
Research on lean, energy-deficient athletic and military cohorts has broadened the concept of the Female Athlete Triad into the Relative Energy Deficiency in Sport (REDs) syndrome. REDs represents a spectrum of abnormalities induced by low ...
The Search for the Causes of Common Hyperandrogenism, 1965 to Circa 2015 [0.03%]
寻找常见雄激素过多综合征的病因：从1965年到大约2015年
Robert L Rosenfield
Robert L Rosenfield
From 1965 to 2015, immense strides were made into understanding the mechanisms underlying the common androgen excess disorders, premature adrenarche and polycystic ovary syndrome (PCOS). The author reviews the critical discoveries of this e...
Mini-Puberty, Physiological and Disordered: Consequences, and Potential for Therapeutic Replacement [0.03%]
微型青春期，生理和紊乱的：影响及治疗替代的可能性
Julia Rohayem,Emma C Alexander,Sabine Heger et al.
Julia Rohayem et al.
There are 3 physiological waves of central hypothalamic-pituitary-gonadal (HPG) axis activity over the lifetime. The first occurs during fetal life, the second-termed "mini-puberty"-in the first months after birth, and the third at puberty....
The Immune Landscape of Pheochromocytoma and Paraganglioma: Current Advances and Perspectives [0.03%]
嗜铬细胞瘤和副神经节瘤的免疫图谱：现状、进展及展望
Ondrej Uher,Katerina Hadrava Vanova,David Taïeb et al.
Ondrej Uher et al.
Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived from neural crest cells from adrenal medullary chromaffin tissues and extra-adrenal paraganglia, respectively. Although the current treatment for PPGLs is s...
Preclinical Rodent Models for Human Bone Disease, Including a Focus on Cortical Bone [0.03%]
人类骨疾病的临床前啮齿动物模型，重点是皮质骨
Natalie Y Y Koh,Justyna J Miszkiewicz,Mary Louise Fac et al.
Natalie Y Y Koh et al.
Preclinical models (typically ovariectomized rats and genetically altered mice) have underpinned much of what we know about skeletal biology. They have been pivotal for developing therapies for osteoporosis and monogenic skeletal conditions...
Genetic and Epigenetic Landscape for Drug Development in Polycystic Ovary Syndrome [0.03%]
多囊卵巢综合征药物研发的遗传和表观遗传景观
Yi Chen,Guiquan Wang,Jingqiao Chen et al.
Yi Chen et al.
The treatment of polycystic ovary syndrome (PCOS) faces challenges as all known treatments are merely symptomatic. The US Food and Drug Administration has not approved any drug specifically for treating PCOS. As the significance of genetics...
The Basis for Weekly Insulin Therapy: Evolving Evidence With Insulin Icodec and Insulin Efsitora Alfa [0.03%]
每周胰岛素治疗的基础：来自胰岛索伊科德和胰岛素厄西托拉阿尔法的不断演进的证据
Julio Rosenstock,Rattan Juneja,John M Beals et al.
Julio Rosenstock et al.
Basal insulin continues to be a vital part of therapy for many people with diabetes. First attempts to prolong the duration of insulin formulations were through the development of suspensions that required homogenization prior to injection....
Henri J L M Timmers,David Taïeb,Karel Pacak et al.
Henri J L M Timmers et al.
Pheochromocytomas/paragangliomas are unique in their highly variable molecular landscape driven by genetic alterations, either germline or somatic. These mutations translate into different clusters with distinct tumor locations, biochemical...