Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases [0.03%]
炎症中的串扰现象：基于糖皮质激素受体的机制与激酶和磷酸酶之间的相互作用
Ilse M E Beck,Wim Vanden Berghe,Linda Vermeulen et al.
Ilse M E Beck et al.
Glucocorticoids (GCs) are steroidal ligands for the GC receptor (GR), which can function as a ligand-activated transcription factor. These steroidal ligands and derivatives thereof are the first line of treatment in a vast array of inflamma...
Anjaneyulu Kowluru
Anjaneyulu Kowluru
Glucose-stimulated insulin secretion from the islet beta-cell involves a sequence of metabolic events and an interplay between a wide range of signaling pathways leading to the generation of second messengers (e.g., cyclic nucleotides, aden...
Steroidogenesis in the fetal testis and its susceptibility to disruption by exogenous compounds [0.03%]
胎儿睾丸类固醇生物合成及其被外来化合物干扰的易感性
Hayley M Scott,J Ian Mason,Richard M Sharpe
Hayley M Scott
Masculinization depends on adequate production of testosterone by the fetal testis within a specific "masculinization programming window." Disorders resulting from subtle deficiencies in this process are common in humans, and environmental ...
The role of mitochondria in the pathophysiology of skeletal muscle insulin resistance [0.03%]
线粒体在骨骼肌胰岛素抵抗病理生理学中的作用
Ines Pagel-Langenickel,Jianjun Bao,Liyan Pang et al.
Ines Pagel-Langenickel et al.
Multiple organs contribute to the development of peripheral insulin resistance, with the major contributors being skeletal muscle, liver, and adipose tissue. Because insulin resistance usually precedes the development of type 2 diabetes mel...
Oren Froy
Oren Froy
Obesity has become a serious public health problem and a major risk factor for the development of illnesses, such as insulin resistance and hypertension. Human homeostatic systems have adapted to daily changes in light and dark in a way tha...
Effects of intrauterine exposure to synthetic glucocorticoids on fetal, newborn, and infant hypothalamic-pituitary-adrenal axis function in humans: a systematic review [0.03%]
人工合成糖皮质激素宫内暴露对人类胎儿、新生儿及婴儿下丘脑-垂体-肾上腺轴功能影响的系统评价
Marion Tegethoff,Christopher Pryce,Gunther Meinlschmidt
Marion Tegethoff
Background: Synthetic glucocorticoids are commonly used in reproductive medicine. Fetal organ systems are highly sensitive to changes in the intrauterine environment, including overexposure to glucocorticoids. Structural ...
Daniel Kelberman,Karine Rizzoti,Robin Lovell-Badge et al.
Daniel Kelberman et al.
Normal hypothalamopituitary development is closely related to that of the forebrain and is dependent upon a complex genetic cascade of transcription factors and signaling molecules that may be either intrinsic or extrinsic to the developing...
Mark A Edson,Ankur K Nagaraja,Martin M Matzuk
Mark A Edson
Two major functions of the mammalian ovary are the production of germ cells (oocytes), which allow continuation of the species, and the generation of bioactive molecules, primarily steroids (mainly estrogens and progestins) and peptide grow...
Amy E Oakley,Donald K Clifton,Robert A Steiner
Amy E Oakley
Kisspeptin (a product of the Kiss1 gene) and its receptor (GPR54 or Kiss1r) have emerged as key players in the regulation of reproduction. Mutations in humans or genetically targeted deletions in mice of either Kiss1 or Kiss1r cause profoun...
Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease [0.03%]
胰岛素受体异构体和胰岛素受体/类胰岛素生长因子受体嵌合体在生理学和疾病中的作用
Antonino Belfiore,Francesco Frasca,Giuseppe Pandini et al.
Antonino Belfiore et al.
In mammals, the insulin receptor (IR) gene has acquired an additional exon, exon 11. This exon may be skipped in a developmental and tissue-specific manner. The IR, therefore, occurs in two isoforms (exon 11 minus IR-A and exon 11 plus IR-B...