Charles L Brooks
Charles L Brooks
Prolactin and the prolactin receptors are members of a family of hormone/receptor pairs which include GH, erythropoietin, and other ligand/receptor pairs. The mechanisms of these ligand/receptor pairs have broad similarities, including gene...
The mammalian tribbles homolog TRIB3, glucose homeostasis, and cardiovascular diseases [0.03%]
哺乳动物分裂素同源物TRIB3、糖代谢稳态与心血管疾病的关系研究
Sabrina Prudente,Giorgio Sesti,Assunta Pandolfi et al.
Sabrina Prudente et al.
Insulin signaling plays a physiological role in traditional insulin target tissues controlling glucose homeostasis as well as in pancreatic β-cells and in the endothelium. Insulin signaling abnormalities may, therefore, be pathogenic for i...
All bariatric surgeries are not created equal: insights from mechanistic comparisons [0.03%]
所有的代谢手术效果不同：来自机制比较的见解
Margaret A Stefater,Hilary E Wilson-Pérez,Adam P Chambers et al.
Margaret A Stefater et al.
Despite considerable scientific progress on the biological systems that regulate energy balance, we have made precious little headway in providing new treatments to curb the obesity epidemic. Diet and exercise are the most popular treatment...
Maria Dalamaga,Kalliope N Diakopoulos,Christos S Mantzoros
Maria Dalamaga
Excess body weight is associated not only with an increased risk of type 2 diabetes and cardiovascular disease (CVD) but also with various types of malignancies. Adiponectin, the most abundant protein secreted by adipose tissue, exhibits in...
Allosteric modulators of steroid hormone receptors: structural dynamics and gene regulation [0.03%]
类固醇激素受体变构调节剂：结构动态与基因调控
Raj Kumar,Iain J McEwan
Raj Kumar
Steroid hormones are synthesized from cholesterol primarily in the adrenal gland and the gonads and play vital roles in normal physiology, the control of development, differentiation, metabolic homeostasis, and reproduction. The actions of ...
Hormone replacement therapy and physical function in healthy older men. Time to talk hormones? [0.03%]
激素替代疗法与健康老年男性的身体机能状况——是时候讨论男性荷尔蒙问题了吗？
Manthos G Giannoulis,Finbarr C Martin,K Sreekumaran Nair et al.
Manthos G Giannoulis et al.
Improving physical function and mobility in a continuously expanding elderly population emerges as a high priority of medicine today. Muscle mass, strength/power, and maximal exercise capacity are major determinants of physical function, an...
Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses [0.03%]
激素和干扰素：低剂量效应和非单调剂量反应
Laura N Vandenberg,Theo Colborn,Tyrone B Hayes et al.
Laura N Vandenberg et al.
For decades, studies of endocrine-disrupting chemicals (EDCs) have challenged traditional concepts in toxicology, in particular the dogma of "the dose makes the poison," because EDCs can have effects at low doses that are not predicted by e...
New roles of carboxypeptidase E in endocrine and neural function and cancer [0.03%]
羧肽酶E在内分泌、神经功能和癌症中的新作用
Niamh X Cawley,William C Wetsel,Saravana R K Murthy et al.
Niamh X Cawley et al.
Carboxypeptidase E (CPE) or carboxypeptidase H was first discovered in 1982 as an enkephalin-convertase that cleaved a C-terminal basic residue from enkephalin precursors to generate enkephalin. Since then, CPE has been shown to be a multif...
Growth hormone doping in sports: a critical review of use and detection strategies [0.03%]
生长激素在体育中的滥用及检测策略批判综述
Gerhard P Baumann
Gerhard P Baumann
GH is believed to be widely employed in sports as a performance-enhancing substance. Its use in athletic competition is banned by the World Anti-Doping Agency, and athletes are required to submit to testing for GH exposure. Detection of GH ...
Prolactin and growth hormone aggregates in secretory granules: the need to understand the structure of the aggregate [0.03%]
泌乳素和生长激素聚合体在分泌颗粒中的结构研究
Priscilla S Dannies
Priscilla S Dannies
Prolactin and GH form reversible aggregates in the trans-Golgi lumen that become the dense cores of secretory granules. Aggregation is an economical means of sorting, because self-association removes the hormones from other possible pathway...