Cyclic decidualization of the human endometrium in reproductive health and failure [0.03%]
子宫内膜蜕膜化在生殖健康和失败中的作用
Birgit Gellersen,Jan J Brosens
Birgit Gellersen
Decidualization denotes the transformation of endometrial stromal fibroblasts into specialized secretory decidual cells that provide a nutritive and immunoprivileged matrix essential for embryo implantation and placental development. In con...
Inhibin at 90: from discovery to clinical application, a historical review [0.03%]
生长抑素发现九十周年：从发现到临床应用的历史回顾
Yogeshwar Makanji,Jie Zhu,Rama Mishra et al.
Yogeshwar Makanji et al.
When it was initially discovered in 1923, inhibin was characterized as a hypophysiotropic hormone that acts on pituitary cells to regulate pituitary hormone secretion. Ninety years later, what we know about inhibin stretches far beyond its ...
Current approaches and recent developments in the management of head and neck paragangliomas [0.03%]
头颈部副神经节瘤的目前治疗手段和最新研究进展
David Taïeb,Alexandre Kaliski,Carsten C Boedeker et al.
David Taïeb et al.
Head and neck paragangliomas (HNPGLs) are rare neuroendocrine tumors belonging to the family of pheochromocytoma/paraganglioma neoplasms. Despite advances in understanding the pathogenesis of these tumors, the growth potential and clinical ...
Ka Kit Wong,Lorraine M Fig,Ehab Youssef et al.
Ka Kit Wong et al.
Nuclear medicine imaging of endocrine disorders takes advantage of unique cellular properties of endocrine organs and tissues that can be depicted by targeted radiopharmaceuticals. Detailed functional maps of biodistributions of radiopharma...
Comprehensive overview of the structure and regulation of the glucocorticoid receptor [0.03%]
糖皮质激素受体的结构和调节的全面综述
Sofie Vandevyver,Lien Dejager,Claude Libert
Sofie Vandevyver
Glucocorticoids are among the most prescribed drugs worldwide for the treatment of numerous immune and inflammatory disorders. They exert their actions by binding to the glucocorticoid receptor (GR), a member of the nuclear receptor superfa...
Laura K Fonken,Randy J Nelson
Laura K Fonken
Most organisms display endogenously produced ∼ 24-hour fluctuations in physiology and behavior, termed circadian rhythms. Circadian rhythms are driven by a transcriptional-translational feedback loop that is hierarchically expressed throug...
Chaperoning G protein-coupled receptors: from cell biology to therapeutics [0.03%]
G蛋白偶联受体的伴侣蛋白：从细胞生物学至药物疗法
Ya-Xiong Tao,P Michael Conn
Ya-Xiong Tao
G protein-coupled receptors (GPCRs) are membrane proteins that traverse the plasma membrane seven times (hence, are also called 7TM receptors). The polytopic structure of GPCRs makes the folding of GPCRs difficult and complex. Indeed, many ...
Duk-Hee Lee,Miquel Porta,David R Jacobs Jr et al.
Duk-Hee Lee et al.
Persistent organic pollutants (POPs) are lipophilic compounds that travel with lipids and accumulate mainly in adipose tissue. Recent human evidence links low-dose POPs to an increased risk of type 2 diabetes (T2D). Because humans are conta...
Craniopharyngioma [0.03%]
颅咽管瘤
Hermann L Müller
Hermann L Müller
This report is a review of findings on the diagnosis, treatment, clinical course, and prognosis of craniopharyngioma patients. Craniopharyngiomas are rare, partly cystic and calcified embryonic malformations of the sellar/parasellar region ...
Isolated growth hormone deficiency (GHD) in childhood and adolescence: recent advances [0.03%]
儿童和青少年孤立性生长激素缺乏症的近期研究进展
Kyriaki S Alatzoglou,Emma Alice Webb,Paul Le Tissier et al.
Kyriaki S Alatzoglou et al.
The diagnosis of GH deficiency (GHD) in childhood is a multistep process involving clinical history, examination with detailed auxology, biochemical testing, and pituitary imaging, with an increasing contribution from genetics in patients w...