Discovering Genes Essential to the Hypothalamic Regulation of Human Reproduction Using a Human Disease Model: Adjusting to Life in the "-Omics" Era [0.03%]
利用人类疾病模型发现对人脑下丘脑生殖调控必不可少的基因——适应“组学”时代的生命规律
M I Stamou,K H Cox,William F Crowley Jr
M I Stamou
The neuroendocrine regulation of reproduction is an intricate process requiring the exquisite coordination of an assortment of cellular networks, all converging on the GnRH neurons. These neurons have a complex life history, migrating mainl...
Dolores D Mruk,C Yan Cheng
Dolores D Mruk
Spermatogenesis is the cellular process by which spermatogonia develop into mature spermatids within seminiferous tubules, the functional unit of the mammalian testis, under the structural and nutritional support of Sertoli cells and the pr...
Leonard Wartofsky
Leonard Wartofsky
Changing of the Guard [0.03%]
代际更迭
Margaret E Wierman,William W Chin,David R Clemmons et al.
Margaret E Wierman et al.
Jonathan W Mueller,Lorna C Gilligan,Jan Idkowiak et al.
Jonathan W Mueller et al.
Steroid sulfation and desulfation are fundamental pathways vital for a functional vertebrate endocrine system. After biosynthesis, hydrophobic steroids are sulfated to expedite circulatory transit. Target cells express transmembrane organic...
Rosario Pivonello,Monica De Leo,Alessia Cozzolino et al.
Rosario Pivonello et al.
Cushing's disease (CD), or pituitary-dependent Cushing's syndrome, is a severe endocrine disease caused by a corticotroph pituitary tumor and associated with increased morbidity and mortality. The first-line treatment for CD is pituitary su...
Determinants of Receptor- and Tissue-Specific Actions in Androgen Signaling [0.03%]
雄激素信号中的受体和组织特异性作用的决定因素
Päivi Pihlajamaa,Biswajyoti Sahu,Olli A Jänne
Päivi Pihlajamaa
The physiological androgens testosterone and 5α-dihydrotestosterone regulate the development and maintenance of primary and secondary male sexual characteristics through binding to the androgen receptor (AR), a ligand-dependent transcripti...
Pituitary dysfunction after traumatic brain injury: a clinical and pathophysiological approach [0.03%]
创伤性脑损伤后的垂体功能障碍：临床与病理生理学方法
Fatih Tanriverdi,Harald Jörn Schneider,Gianluca Aimaretti et al.
Fatih Tanriverdi et al.
Traumatic brain injury (TBI) is a growing public health problem worldwide and is a leading cause of death and disability. The causes of TBI include motor vehicle accidents, which are the most common cause, falls, acts of violence, sports-re...
Zachary Gerhart-Hines,Mitchell A Lazar
Zachary Gerhart-Hines
Circadian rhythm, or daily oscillation, of behaviors and biological processes is a fundamental feature of mammalian physiology that has developed over hundreds of thousands of years under the continuous evolutionary pressure of energy conse...