TSH Receptor Cleavage Into Subunits and Shedding of the A-Subunit; A Molecular and Clinical Perspective [0.03%]
从分子和临床角度解析甲状腺刺激素受体的解离及A亚基的释放反应
Basil Rapoport,Sandra M McLachlan
Basil Rapoport
The TSH receptor (TSHR) on the surface of thyrocytes is unique among the glycoprotein hormone receptors in comprising two subunits: an extracellular A-subunit, and a largely transmembrane and cytosolic B-subunit. Unlike its ligand TSH, whos...
Growth and the Growth Hormone-Insulin Like Growth Factor 1 Axis in Children With Chronic Inflammation: Current Evidence, Gaps in Knowledge, and Future Directions [0.03%]
儿童慢性炎症与生长激素-胰岛素样生长因子1轴的相关性：现有证据、知识空白及未来方向
S C Wong,R Dobie,M A Altowati et al.
S C Wong et al.
Growth failure is frequently encountered in children with chronic inflammatory conditions like juvenile idiopathic arthritis, inflammatory bowel disease, and cystic fibrosis. Delayed puberty and attenuated pubertal growth spurt are often se...
Post-Transplant Diabetes Mellitus: Causes, Treatment, and Impact on Outcomes [0.03%]
移植后糖尿病：病因、治疗及对预后的影响
Vijay Shivaswamy,Brian Boerner,Jennifer Larsen
Vijay Shivaswamy
Post-transplant diabetes mellitus (PTDM) is a frequent consequence of solid organ transplantation. PTDM has been associated with greater mortality and increased infections in different transplant groups using different diagnostic criteria. ...
Published Erratum
Endocrine reviews. 2015 Dec;36(6):681. DOI:10.1210/er.2015-1127 2015
Thyroglobulin From Molecular and Cellular Biology to Clinical Endocrinology [0.03%]
从分子和细胞生物学至临床内分泌学的甲状腺球蛋白研究进展
Bruno Di Jeso,Peter Arvan
Bruno Di Jeso
Thyroglobulin (Tg) is a vertebrate secretory protein synthesized in the thyrocyte endoplasmic reticulum (ER), where it acquires N-linked glycosylation and conformational maturation (including formation of many disulfide bonds), leading to h...
EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals [0.03%]
内分泌紊乱化学物的科学声明第二部分：来自内分泌协会的第二份官方文件
A C Gore,V A Chappell,S E Fenton et al.
A C Gore et al.
The Endocrine Society's first Scientific Statement in 2009 provided a wake-up call to the scientific community about how environmental endocrine-disrupting chemicals (EDCs) affect health and disease. Five years later, a substantially larger...
Alberto Roselló-Díez,Alexandra L Joyner
Alberto Roselló-Díez
The regulation of organ size is essential to human health and has fascinated biologists for centuries. Key to the growth process is the ability of most organs to integrate organ-extrinsic cues (eg, nutritional status, inflammatory processes...
Scientific Statement on the Diagnostic Criteria, Epidemiology, Pathophysiology, and Molecular Genetics of Polycystic Ovary Syndrome [0.03%]
多囊卵巢综合征的诊断标准、流行病学、病理生理和分子遗传学的科学声明
Daniel A Dumesic,Sharon E Oberfield,Elisabet Stener-Victorin et al.
Daniel A Dumesic et al.
Polycystic ovary syndrome (PCOS) is a heterogeneous and complex disorder that has both adverse reproductive and metabolic implications for affected women. However, there is generally poor understanding of its etiology. Varying expert-based ...
Executive Summary to EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals [0.03%]
环境内分泌干扰物孙山会第２号科学声明概要
A C Gore,V A Chappell,S E Fenton et al.
A C Gore et al.
This Executive Summary to the Endocrine Society's second Scientific Statement on environmental endocrine-disrupting chemicals (EDCs) provides a synthesis of the key points of the complete statement. The full Scientific Statement represents ...
Pituitary Apoplexy [0.03%]
垂体卒中
Claire Briet,Sylvie Salenave,Jean-François Bonneville et al.
Claire Briet et al.
Pituitary apoplexy, a rare clinical syndrome secondary to abrupt hemorrhage or infarction, complicates 2%-12% of pituitary adenomas, especially nonfunctioning tumors. Headache of sudden and severe onset is the main symptom, sometimes associ...