PCSK1 Mutations and Human Endocrinopathies: From Obesity to Gastrointestinal Disorders [0.03%]
PCSCK1基因突变与人类内分泌病：从肥胖到胃肠道疾病
Pieter Stijnen,Bruno Ramos-Molina,Stephen O&#x;Rahilly et al.
Pieter Stijnen et al.
Prohormone convertase 1/3, encoded by the PCSK1 gene, is a serine endoprotease that is involved in the processing of a variety of proneuropeptides and prohormones. Humans who are homozygous or compound heterozygous for loss-of-function muta...
Current Understanding on Role of the Wnt Signaling Pathway Effector TCF7L2 in Glucose Homeostasis [0.03%]
TCF7L2在葡萄糖稳态中的作用机制研究进展
Tianru Jin
Tianru Jin
The role of the Wnt signaling pathway in metabolic homeostasis has drawn our intensive attention, especially after the genome-wide association study discovery that certain polymorphisms of its key effector TCF7L2 are strongly associated wit...
Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus [0.03%]
2型糖尿病的性别和临床表现差异：发病风险、病理生理及并发症方面存在的性别差异分析
Alexandra Kautzky-Willer,Jürgen Harreiter,Giovanni Pacini
Alexandra Kautzky-Willer
The steep rise of type 2 diabetes mellitus (T2DM) and associated complications go along with mounting evidence of clinically important sex and gender differences. T2DM is more frequently diagnosed at lower age and body mass index in men; ho...
Stefano Zanotti,Ernesto Canalis
Stefano Zanotti
Notch 1 to 4 receptors are important determinants of cell fate and function, and Notch signaling plays an important role in skeletal development and bone remodeling. After direct interactions with ligands of the Jagged and Delta-like famili...
Letter to the Editor: Response to "Second Scientific Statement on Endocrine-Disrupting Chemicals" by Gore et al [0.03%]
致编辑信件：回复Gore等人的“内分泌干扰物第二次科学声明”
David Dix,Whitney Weber
David Dix
Monogenic Diabetes: What It Teaches Us on the Common Forms of Type 1 and Type 2 Diabetes [0.03%]
单基因糖尿病：其研究对1型和2型糖尿病的启示
Yisheng Yang,Lawrence Chan
Yisheng Yang
To date, more than 30 genes have been linked to monogenic diabetes. Candidate gene and genome-wide association studies have identified > 50 susceptibility loci for common type 1 diabetes (T1D) and approximately 100 susceptibility loci for t...
J H Duncan Bassett,Graham R Williams
J H Duncan Bassett
The skeleton is an exquisitely sensitive and archetypal T3-target tissue that demonstrates the critical role for thyroid hormones during development, linear growth, and adult bone turnover and maintenance. Thyrotoxicosis is an established c...
From the Editor-in-Chief of Endocrine Reviews on the Occasion of the 2016 Centennial of the Endocrine Society [0.03%]
内分泌学会百年华诞致《内分泌评论》读者的一封信
Leonard Wartofsky
Leonard Wartofsky