The Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids [0.03%]
循环皮质类固醇的24小时节律的功能和临床意义
Henrik Oster,Etienne Challet,Volker Ott et al.
Henrik Oster et al.
Adrenal glucocorticoids are major modulators of multiple functions, including energy metabolism, stress responses, immunity, and cognition. The endogenous secretion of glucocorticoids is normally characterized by a prominent and robust circ...
Vascular Biology of Glucagon Receptor Superfamily Peptides: Mechanistic and Clinical Relevance [0.03%]
胰高血糖素受体超家族肽的血管生物学：机制和临床相关性
Gemma Pujadas,Daniel J Drucker
Gemma Pujadas
Regulatory peptides produced in islet and gut endocrine cells, including glucagon, glucagon-like peptide-1 (GLP-1), GLP-2, and glucose-dependent insulinotropic polypeptide, exert actions with considerable metabolic importance and translatio...
The Pathophysiologic Role of Disrupted Circadian and Neuroendocrine Rhythms in Breast Carcinogenesis [0.03%]
节律紊乱在乳腺癌发生中的病理生理作用
Lonnele J Ball,Oxana Palesh,Lance J Kriegsfeld
Lonnele J Ball
Most physiological processes in the brain and body exhibit daily (circadian) rhythms coordinated by an endogenous master clock located in the suprachiasmatic nucleus of the hypothalamus that are essential for normal health and functioning. ...
Premature Ovarian Insufficiency: New Perspectives on Genetic Cause and Phenotypic Spectrum [0.03%]
卵巢早衰：遗传原因及表型谱的新视角
Elena J Tucker,Sonia R Grover,Anne Bachelot et al.
Elena J Tucker et al.
Premature ovarian insufficiency (POI) is one form of female infertility, defined by loss of ovarian activity before the age of 40 and characterized by amenorrhea (primary or secondary) with raised gonadotropins and low estradiol. POI affect...
Peter J Tebben,Ravinder J Singh,Rajiv Kumar
Peter J Tebben
Hypercalcemia occurs in up to 4% of the population in association with malignancy, primary hyperparathyroidism, ingestion of excessive calcium and/or vitamin D, ectopic production of 1,25-dihydroxyvitamin D [1,25(OH)2D], and impaired degrad...
The Pathogenesis of Polycystic Ovary Syndrome (PCOS): The Hypothesis of PCOS as Functional Ovarian Hyperandrogenism Revisited [0.03%]
多囊卵巢综合征的发病机理——作为功能性卵巢高胰岛素血症的多囊卵综合征假说需重新审视
Robert L Rosenfield,David A Ehrmann
Robert L Rosenfield
Polycystic ovary syndrome (PCOS) was hypothesized to result from functional ovarian hyperandrogenism (FOH) due to dysregulation of androgen secretion in 1989-1995. Subsequent studies have supported and amplified this hypothesis. When define...