Michael W Schwartz,Randy J Seeley,Lori M Zeltser et al.
Michael W Schwartz et al.
Obesity is among the most common and costly chronic disorders worldwide. Estimates suggest that in the United States obesity affects one-third of adults, accounts for up to one-third of total mortality, is concentrated among lower income gr...
A Reappraisal of Testosterone's Binding in Circulation: Physiological and Clinical Implications [0.03%]
重新评估循环中睾酮的结合：生理和临床意义
Anna L Goldman,Shalender Bhasin,Frederick C W Wu et al.
Anna L Goldman et al.
In the circulation, testosterone and other sex hormones are bound to binding proteins, which play an important role in regulating their transport, distribution, metabolism, and biological activity. According to the free hormone hypothesis, ...
Cathepsin K Inhibitors for Osteoporosis: Biology, Potential Clinical Utility, and Lessons Learned [0.03%]
猫唾液酸K抑制剂在骨质疏松症中的作用：生物学、潜在临床应用及经验教训
Matthew T Drake,Bart L Clarke,Merry Jo Oursler et al.
Matthew T Drake et al.
Cathepsin K is a cysteine protease member of the cathepsin lysosomal protease family. Although cathepsin K is highly expressed in osteoclasts, lower levels of cathepsin K are also found in a variety of other tissues. Secretion of cathepsin ...
Megan R Haymart,Nazanene H Esfandiari,Michael T Stang et al.
Megan R Haymart et al.
Controversy exists over optimal management of low-risk differentiated thyroid cancer. This controversy occurs in all aspects of management, including surgery, use of radioactive iodine for remnant ablation, thyroid hormone supplementation, ...
Richard O&#x;Grady
Richard O&#x;Grady
Bradley D Anawalt
Bradley D Anawalt
Wen-Chih Lee,Anyonya R Guntur,Fanxin Long et al.
Wen-Chih Lee et al.
Osteoblasts, the bone-forming cells of the remodeling unit, are essential for growth and maintenance of the skeleton. Clinical disorders of substrate availability (e.g., diabetes mellitus, anorexia nervosa, and aging) cause osteoblast dysfu...
Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels [0.03%]
二氢睾酮：血液水平升高的生物化学、生理和临床意义
Ronald S Swerdloff,Robert E Dudley,Stephanie T Page et al.
Ronald S Swerdloff et al.
Benefits associated with lowered serum DHT levels after 5α-reductase inhibitor (5AR-I) therapy in men have contributed to a misconception that circulating DHT levels are an important stimulus for androgenic action in target tissues (e.g., ...
Glucose Metabolism Abnormalities in Cushing Syndrome: From Molecular Basis to Clinical Management [0.03%]
库欣综合征的葡萄糖代谢异常：从分子机制到临床管理
Carla Scaroni,Marialuisa Zilio,Michelangelo Foti et al.
Carla Scaroni et al.
An impaired glucose metabolism, which often leads to the onset of diabetes mellitus (DM), is a common complication of chronic exposure to exogenous and endogenous glucocorticoid (GC) excess and plays an important part in contributing to mor...
Nadia Berkane,Philippe Liere,Jean-Paul Oudinet et al.
Nadia Berkane et al.
Preeclampsia (PE) results in placental dysfunction and is one of the primary causes of maternal and fetal mortality and morbidity. During pregnancy, estrogen is produced primarily in the placenta by conversion of androgen precursors origina...