The Hippo Signaling Pathway in Pancreatic β-Cells: Functions and Regulations [0.03%]
胰岛素分泌细胞中的Hippo信号通路：功能与调控
Amin Ardestani,Kathrin Maedler
Amin Ardestani
Hippo signaling is an evolutionarily conserved pathway that critically regulates development and homeostasis of various tissues in response to a wide range of extracellular and intracellular signals. As an emerging important player in many ...
Ovarian Follicular Theca Cell Recruitment, Differentiation, and Impact on Fertility: 2017 Update [0.03%]
卵巢卵泡颗粒细胞募集、分化及对生育的影响(2017年更新)
JoAnne S Richards,Yi A Ren,Nicholes Candelaria et al.
JoAnne S Richards et al.
The major goal of this review is to summarize recent exciting findings that have been published within the past 10 years that, to our knowledge, have not been presented in detail in previous reviews and that may impact altered follicular de...
Antonino Belfiore,Roberta Malaguarnera,Veronica Vella et al.
Antonino Belfiore et al.
The insulin receptor (IR) gene undergoes differential splicing that generates two IR isoforms, IR-A and IR-B. The physiological roles of IR isoforms are incompletely understood and appear to be determined by their different binding affiniti...
Maria-Christina Zennaro,Sheerazed Boulkroun,Fabio Fernandes-Rosa
Maria-Christina Zennaro
Aldosterone and cortisol, the main mineralocorticoid and glucocorticoid hormones in humans, are produced in the adrenal cortex, which is composed of three concentric zones with specific functional characteristics. Adrenocortical adenomas (A...
Pulmonary Function and Sleep Breathing: Two New Targets for Type 2 Diabetes Care [0.03%]
肺功能和睡眠呼吸：治疗2型糖尿病的两个新靶点
Albert Lecube,Rafael Simó,Maria Pallayova et al.
Albert Lecube et al.
Population-based studies showing the negative impact of type 2 diabetes (T2D) on lung function are overviewed. Among the well-recognized pathophysiological mechanisms, the metabolic pathways related to insulin resistance (IR), low-grade chr...
Taming the Flames: Targeting White Adipose Tissue Browning in Hypermetabolic Conditions [0.03%]
降服火焰：靶向高代谢状态下的白色脂肪组织褐变
Abdikarim Abdullahi,Marc G Jeschke
Abdikarim Abdullahi
In this era of increased obesity and diabetes prevalence, the browning of white adipose tissue (WAT) has emerged as a promising therapeutic target to induce weight loss and improve insulin sensitivity in this population. The browning proces...
Luba Sominsky,Deborah M Hodgson,Eileen A McLaughlin et al.
Luba Sominsky et al.
Infertility affects a remarkable one in four couples in developing countries. Psychological stress is a ubiquitous facet of life, and although stress affects us all at some point, prolonged or unmanageable stress may become harmful for some...
New Perspectives on Pheochromocytoma and Paraganglioma: Toward a Molecular Classification [0.03%]
pheochromocyt瘤和副神经节瘤的分子分类的新视角
Joakim Crona,David Taïeb,Karel Pacak
Joakim Crona
A molecular biology-based taxonomy has been proposed for pheochromocytoma and paraganglioma (PPGL). Data from the Cancer Genome Atlas revealed clinically relevant prognostic and predictive biomarkers and stratified PPGLs into three main clu...
Harald Staiger,Michaela Keuper,Lucia Berti et al.
Harald Staiger et al.
Since its identification in 2000, the interest of scientists in the hepatokine fibroblast growth factor (FGF) 21 has tremendously grown, and still remains high, due to a wealth of very robust data documenting this factor's favorable effects...
David J Handelsman
David J Handelsman