Klinefelter Syndrome: Integrating Genetics, Neuropsychology, and Endocrinology [0.03%]
克莱费尔特综合征：遗传学、神经心理学和内分泌学的整合研究
Claus H Gravholt,Simon Chang,Mikkel Wallentin et al.
Claus H Gravholt et al.
Although first identified over 70 years ago, Klinefelter syndrome (KS) continues to pose substantial diagnostic challenges, as many patients are still misdiagnosed, or remain undiagnosed. In fact, as few as 25% of patients with KS are accur...
Carlos Simon,David W Greening,David Bolumar et al.
Carlos Simon et al.
Extensive evidence suggests that the release of membrane-enclosed compartments, more commonly known as extracellular vesicles (EVs), is a potent newly identified mechanism of cell-to-cell communication both in normal physiology and in patho...
11β-HSD1 in Human Fetal Membranes as a Potential Therapeutic Target for Preterm Birth [0.03%]
人胎膜中11β-HSD1作为早产治疗靶点的潜力
Wangsheng Wang,Zi-Jiang Chen,Leslie Myatt et al.
Wangsheng Wang et al.
Human parturition is a complex process involving interactions between the myometrium and signals derived from the placenta, fetal membranes, and fetus. Signals originating from fetal membranes are crucial components that trigger parturition...
Vicente Gilsanz,Tishya A L Wren,Skorn Ponrartana et al.
Vicente Gilsanz et al.
Recent observations indicate that the cross-sectional area (CSA) of vertebral bodies is on average 10% smaller in healthy newborn girls than in newborn boys, a striking difference that increases during infancy and puberty and is greatest by...
X-Linked Hypophosphatemia and FGF23-Related Hypophosphatemic Diseases: Prospect for New Treatment [0.03%]
X连锁低磷血症和FGF23相关性低磷血症性疾病：新的治疗方法展望
Yuka Kinoshita,Seiji Fukumoto
Yuka Kinoshita
Phosphate plays essential roles in many biological processes, and the serum phosphate level is tightly controlled. Chronic hypophosphatemia causes impaired mineralization of the bone matrix and results in rickets and osteomalacia. Fibroblas...
The Versatile Tanycyte: A Hypothalamic Integrator of Reproduction and Energy Metabolism [0.03%]
多才多艺的tan细胞：下丘脑生殖和能量代谢整合器
Vincent Prevot,Bénédicte Dehouck,Ariane Sharif et al.
Vincent Prevot et al.
The fertility and survival of an individual rely on the ability of the periphery to promptly, effectively, and reproducibly communicate with brain neural networks that control reproduction, food intake, and energy homeostasis. Tanycytes, a ...
The Extending Spectrum of NPC1-Related Human Disorders: From Niemann-Pick C1 Disease to Obesity [0.03%]
NPC1相关人类疾病的谱系扩展：从尼曼匹克C1病到肥胖症
Amel Lamri,Marie Pigeyre,William S Garver et al.
Amel Lamri et al.
The Niemann-Pick type C1 (NPC1) protein regulates the transport of cholesterol and fatty acids from late endosomes/lysosomes and has a central role in maintaining lipid homeostasis. NPC1 loss-of-function mutations in humans cause NPC1 disea...
Evaluating Causality of Gut Microbiota in Obesity and Diabetes in Humans [0.03%]
人体肠道微生态因果关系评价研究肥胖及糖尿病进展中的作用
Abraham S Meijnikman,Victor E Gerdes,Max Nieuwdorp et al.
Abraham S Meijnikman et al.
The pathophysiology of obesity and obesity-related diseases such as type 2 diabetes mellitus (T2DM) is complex and driven by many factors. One of the most recently identified factors in development of these metabolic pathologies is the gut ...
Janet P Hapgood,Charu Kaushic,Zdenek Hel
Janet P Hapgood
Access to effective affordable contraception is critical for individual and public health. A wide range of hormonal contraceptives (HCs), which differ in composition, concentration of the progestin component, frequency of dosage, and method...
Diagnostic Utility of Molecular and Imaging Biomarkers in Cytological Indeterminate Thyroid Nodules [0.03%]
细胞学诊断不明确的甲状腺结节中分子和影像生物标志物的诊断效用
Elizabeth J de Koster,Lioe-Fee de Geus-Oei,Olaf M Dekkers et al.
Elizabeth J de Koster et al.
Indeterminate thyroid cytology (Bethesda III and IV) corresponds to follicular-patterned benign and malignant lesions, which are particularly difficult to differentiate on cytology alone. As ~25% of these nodules harbor malignancy, diagnost...