Mone Zaidi,Tony Yuen,Li Sun et al.
Mone Zaidi et al.
Landmark advances in skeletal biology have arisen mainly from the identification of disease-causing mutations and the advent of rapid and selective gene-targeting technologies to phenocopy human disease in mice. Here, we discuss work on new...
At the Crossroads of Fate-Somatic Cell Lineage Specification in the Fetal Gonad [0.03%]
命运的十字路口-胎儿生殖腺体 somatic 细胞谱系规格化
Emmi Rotgers,Anne Jørgensen,Humphrey Hung-Chang Yao
Emmi Rotgers
The reproductive endocrine systems are vastly different between males and females. This sexual dimorphism of the endocrine milieu originates from sex-specific differentiation of the somatic cells in the gonads during fetal life. Most gonada...
Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease [0.03%]
代谢灵活性：健康与疾病状态下的能量资源和需求适应性
Reuben L Smith,Maarten R Soeters,Rob C I Wüst et al.
Reuben L Smith et al.
The ability to efficiently adapt metabolism by substrate sensing, trafficking, storage, and utilization, dependent on availability and requirement, is known as metabolic flexibility. In this review, we discuss the breadth and depth of metab...
Pituitary Diseases and Bone [0.03%]
垂体病与骨质异常
Gherardo Mazziotti,Stefano Frara,Andrea Giustina
Gherardo Mazziotti
Neuroendocrinology of bone is a new area of research based on the evidence that pituitary hormones may directly modulate bone remodeling and metabolism. Skeletal fragility associated with high risk of fractures is a common complication of s...
Sex and Gender Differences Research Design for Basic, Clinical, and Population Studies: Essentials for Investigators [0.03%]
基础、临床和人群研究中的性别与性别的差异研究设计：研究者必读要素
Janet W Rich-Edwards,Ursula B Kaiser,Grace L Chen et al.
Janet W Rich-Edwards et al.
A sex- and gender-informed perspective increases rigor, promotes discovery, and expands the relevance of biomedical research. In the current era of accountability to present data for males and females, thoughtful and deliberate methodology ...
Peter J Snyder,Shalender Bhasin,Glenn R Cunningham et al.
Peter J Snyder et al.
The Testosterone Trials (TTrials) were a coordinated set of seven placebo-controlled, double-blind trials in 788 men with a mean age of 72 years to determine the efficacy of increasing the testosterone levels of older men with low testoster...
The Science of Obesity Management: An Endocrine Society Scientific Statement [0.03%]
《内分泌协会科学声明：肥胖管理的科学》
George A Bray,William E Heisel,Ashkan Afshin et al.
George A Bray et al.
The prevalence of obesity, measured by body mass index, has risen to unacceptable levels in both men and women in the United States and worldwide with resultant hazardous health implications. Genetic, environmental, and behavioral factors i...
The Circadian Clock in White and Brown Adipose Tissue: Mechanistic, Endocrine, and Clinical Aspects [0.03%]
白色和棕色脂肪组织中的昼夜钟：机制、内分泌学及临床意义方面
Oren Froy,Marta Garaulet
Oren Froy
Obesity is a major risk factor for the development of illnesses, such as insulin resistance and hypertension, and has become a serious public health problem. Mammals have developed a circadian clock located in the hypothalamic suprachiasmat...