The Biology of Normal Zona Glomerulosa and Aldosterone-Producing Adenoma: Pathological Implications [0.03%]
正常肾上腺 zona glomerulosa 和分泌醛固酮腺瘤的生物学特性及其病理意义
Teresa M Seccia,Brasilina Caroccia,Elise P Gomez-Sanchez et al.
Teresa M Seccia et al.
The identification of several germline and somatic ion channel mutations in aldosterone-producing adenomas (APAs) and detection of cell clusters that can be responsible for excess aldosterone production, as well as the isolation of autoanti...
Children Born Small for Gestational Age: Differential Diagnosis, Molecular Genetic Evaluation, and Implications [0.03%]
胎龄小的低体重儿：鉴别诊断、分子遗传学评估及其意义
Martijn J J Finken,Manouk van der Steen,Carolina C J Smeets et al.
Martijn J J Finken et al.
Children born small for gestational age (SGA), defined as a birth weight and/or length below -2 SD score (SDS), comprise a heterogeneous group. The causes of SGA are multifactorial and include maternal lifestyle and obstetric factors, place...
Novel Concepts for Inducing Final Oocyte Maturation in In Vitro Fertilization Treatment [0.03%]
体外受精促排卵的新概念
Ali Abbara,Sophie A Clarke,Waljit S Dhillo
Ali Abbara
Infertility affects one in six of the population and increasingly couples require treatment with assisted reproductive techniques. In vitro fertilization (IVF) treatment is most commonly conducted using exogenous FSH to induce follicular gr...
Gonadotropins and Their Analogs: Current and Potential Clinical Applications [0.03%]
促性腺激素及其类似物的临床应用现状与前景
Ross C Anderson,Claire L Newton,Richard A Anderson et al.
Ross C Anderson et al.
The gonadotropin receptors LH receptor and FSH receptor play a central role in governing reproductive competency/fertility. Gonadotropin hormone analogs have been used clinically for decades in assisted reproductive therapies and in the tre...
Interferences With Thyroid Function Immunoassays: Clinical Implications and Detection Algorithm [0.03%]
干扰甲状腺功能免疫测定：临床意义和检测算法
Julien Favresse,Maria-Cristina Burlacu,Dominique Maiter et al.
Julien Favresse et al.
Automated immunoassays used to evaluate thyroid function are vulnerable to different types of interference that can affect clinical decisions. This review provides a detailed overview of the six main types of interference known to affect me...
The RASopathy Family: Consequences of Germline Activation of the RAS/MAPK Pathway [0.03%]
RASopathies相关疾病的家族特征：生殖系活化RAS / MAPK通路的后果
Mylène Tajan,Romain Paccoud,Sophie Branka et al.
Mylène Tajan et al.
Noonan syndrome [NS; Mendelian Inheritance in Men (MIM) #163950] and related syndromes [Noonan syndrome with multiple lentigines (formerly called LEOPARD syndrome; MIM #151100), Noonan-like syndrome with loose anagen hair (MIM #607721), Cos...
Glucocorticoids and Bone: Consequences of Endogenous and Exogenous Excess and Replacement Therapy [0.03%]
糖皮质激素与骨：内源性和外源性过多及替代治疗的后果
Rowan S Hardy,Hong Zhou,Markus J Seibel et al.
Rowan S Hardy et al.
Osteoporosis associated with long-term glucocorticoid therapy remains a common and serious bone disease. Additionally, in recent years it has become clear that more subtle states of endogenous glucocorticoid excess may have a major impact o...
Two Hormones for One Receptor: Evolution, Biochemistry, Actions, and Pathophysiology of LH and hCG [0.03%]
一对激素与一个受体：黄体生成素和人绒毛膜促性腺激素的进化、生化性质及生理病理作用
Livio Casarini,Daniele Santi,Giulia Brigante et al.
Livio Casarini et al.
LH and chorionic gonadotropin (CG) are glycoproteins fundamental to sexual development and reproduction. Because they act on the same receptor (LHCGR), the general consensus has been that LH and human CG (hCG) are equivalent. However, separ...
Targeting the Incretin/Glucagon System With Triagonists to Treat Diabetes [0.03%]
靶向肠促胰岛素/胰高血糖素系统治疗糖尿病
Megan E Capozzi,Richard D DiMarchi,Matthias H Tschöp et al.
Megan E Capozzi et al.
Glucagonlike peptide 1 (GLP-1) receptor agonists have been efficacious for the treatment of type 2 diabetes due to their ability to reduce weight and attenuate hyperglycemia. However, the activity of glucagonlike peptide 1 receptor-directed...
Sylvia C Hewitt,Kenneth S Korach
Sylvia C Hewitt
Nineteen years have passed since our previous review in this journal in 1999 regarding estrogen receptors. At that time, we described the current assessments of the physiological activities of estrogen and estrogen receptors. Since that tim...