Insulin Resistance in Type 1 Diabetes: Pathophysiological, Clinical, and Therapeutic Relevance [0.03%]
1型糖尿病中的胰岛素抵抗：病理生理学、临床和治疗相关性
Maria Apostolopoulou,Vaia Lambadiari,Michael Roden et al.
Maria Apostolopoulou et al.
People with type 1 diabetes (T1D) are usually considered to exclusively exhibit β-cell failure, but they frequently also feature insulin resistance. This review discusses the mechanisms, clinical features, and therapeutic relevance of insu...
The Oxytocin System and Implications for Oxytocin Deficiency in Hypothalamic-Pituitary Disease [0.03%]
下丘脑-垂体疾病中催产素系统的功能及催产素不足的可能影响
Anna Aulinas,Elizabeth A Lawson
Anna Aulinas
Oxytocin is a hypothalamic-posterior pituitary hormone with multiple effects, ranging from regulation of energy homeostasis to bone health and psychological wellbeing, in addition to its well-known effects in labor and lactation. Patients w...
Gian Paolo Rossi,Michele Battistel,Teresa Maria Seccia et al.
Gian Paolo Rossi et al.
Primary aldosteronism (PA), the most common cause of arterial hypertension, is surgically curable if a unilateral source of the hyperaldosteronism is discovered. To identify the patients who are curable, all current guidelines recommend adr...
New horizons in Klinefelter syndrome: current evidence, gaps and research priorities [0.03%]
克兰费尔特综合征的新视野：现有证据、缺口和研究重点
Angela K Lucas-Herald,Lise Aksglaede,Ida Dyhr Caspersen et al.
Angela K Lucas-Herald et al.
Klinefelter Syndrome (KS) is caused by the presence of a supernumerary X-chromosome (conferring the classical 47,XXY karyotype) and is the commonest sex chromosome abnormality in men. The clinical features described in the early characteris...
Anti-obesity pharmacotherapy for patients with genetic obesity due to defects in the leptin-melanocortin pathway [0.03%]
针对瘦素-黑素皮质激素通路缺陷遗传性肥胖患者的抗肥胖药物治疗
Mila S Welling,Elisabeth F C van Rossum,Erica L T van den Akker
Mila S Welling
Lifestyle interventions are the cornerstone of obesity treatment. However, insufficient long-term effects are observed in patients with genetic obesity disorders, as their hyperphagia remains untreated. Hence, patients with genetic obesity ...
Molecular landscape and therapeutic strategies in pediatric differentiated thyroid carcinoma [0.03%]
儿童分化型甲状腺癌的分子图谱和治疗策略
Adeline T Yang,Sin-Ting Tiffany Lai,Theodore W Laetsch et al.
Adeline T Yang et al.
There has been significant progress in understanding the molecular landscape of pediatric differentiated thyroid carcinoma over the past two decades. Classification of pediatric differentiated thyroid carcinoma into three-tiers, RAS-like mu...
Rachel Varughese,Shamima Rahman
Rachel Varughese
Primary mitochondrial disorders (PMD) are genetic disorders affecting the structure or function of the mitochondrion. Mitochondrial functions are diverse, including energy production, ion homeostasis, reactive oxygen species regulation, ant...
Nanna S Svensson,Tabia Volqvartz,Anna Louise Vestergaard et al.
Nanna S Svensson et al.
Vitamin D deficiency during pregnancy is associated with an increased risk of health issues in the offspring. Accordingly, recent Endocrine Society guidelines strongly support supplementation in pregnancy, also underlining that without cons...
Mario J A Saad,Andrey Santos
Mario J A Saad
Obesity is a major global concern and is generally attributed to a combination of genetic and environmental factors. Several hypotheses have been proposed to explain the evolutionary origins of obesity epidemic, including thrifty and drifty...
Vatsal Sachan,Delia Susan-Resiga,Kalista Lam et al.
Vatsal Sachan et al.
Discovered in 1996, PCSK7 is the seventh of the nine-membered proprotein convertase subtilisin-kexin (PCSK) family. This article reviews the various aspects of the multifaceted biology of PCSK7 and what makes it an exciting new target for m...