Manuel H Aguiar-Oliveira,Andrzej Bartke
Manuel H Aguiar-Oliveira
The important role of GH in the control of mammalian longevity was first deduced from extended longevity of mice with genetic GH deficiency (GHD) or GH resistance. Mice with isolated GHD (IGHD) due to GHRH or GHRH receptor mutations, combin...
Pancreatic Islet Transplantation in Humans: Recent Progress and Future Directions [0.03%]
人胰岛移植的近期进展和未来方向
Michael R Rickels,R Paul Robertson
Michael R Rickels
Pancreatic islet transplantation has become an established approach to β-cell replacement therapy for the treatment of insulin-deficient diabetes. Recent progress in techniques for islet isolation, islet culture, and peritransplant managem...
Mathis Grossmann,Margaret E Wierman,Peter Angus et al.
Mathis Grossmann et al.
The liver and the reproductive system interact in a multifaceted bidirectional fashion. Sex steroid signaling influences hepatic endobiotic and xenobiotic metabolism and contributes to the pathogenesis of functional and structural disorders...
Cesar Luiz Boguszewski,Margaret Cristina da Silva Boguszewski
Cesar Luiz Boguszewski
Several components of the GH axis are involved in tumor progression, and GH-induced intracellular signaling has been strongly associated with breast cancer susceptibility in genome-wide association studies. In the general population, high I...
Diane M Duffy,CheMyong Ko,Misung Jo et al.
Diane M Duffy et al.
The midcycle surge of LH sets in motion interconnected networks of signaling cascades to bring about rupture of the follicle and release of the oocyte during ovulation. Many mediators of these LH-induced signaling cascades are associated wi...
Camilla Virili,Alessandro Antonelli,Maria Giulia Santaguida et al.
Camilla Virili et al.
Levothyroxine, a largely prescribed drug with a narrow therapeutic index, is often a lifelong treatment. The therapeutic efficacy of T4 may be marred by behavioral, pharmacologic, and pathologic issues acting as interfering factors. Despite...
Long-Term Endocrine and Metabolic Consequences of Cancer Treatment: A Systematic Review [0.03%]
癌症治疗的长期内分泌和代谢后果：系统评价
Judith Gebauer,Claire Higham,Thorsten Langer et al.
Judith Gebauer et al.
The number of patients surviving ≥5 years after initial cancer diagnosis has significantly increased during the last decades due to considerable improvements in the treatment of many cancer entities. A negative consequence of this is that ...
Starvation in the Midst of Plenty: Reflections on the History and Biology of Insulin and Leptin [0.03%]
丰衣足食中的饥荒——胰岛素和脂抑素的历史与生物学反思
Jeffrey S Flier
Jeffrey S Flier
Insulin and leptin are critical metabolic hormones that play essential but distinct roles in regulating the physiologic switch between the fed and starved states. The discoveries of insulin and leptin, in 1922 and 1994, respectively, arose ...
Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions [0.03%]
维生素D的骨骼与非骨骼作用：现有证据和悬而未决的问题
Roger Bouillon,Claudio Marcocci,Geert Carmeliet et al.
Roger Bouillon et al.
The etiology of endemic rickets was discovered a century ago. Vitamin D is the precursor of 25-hydroxyvitamin D and other metabolites, including 1,25(OH)2D, the ligand for the vitamin D receptor (VDR). The effects of the vitamin D endocrine...