Realizing a Closed-Loop (Artificial Pancreas) System for the Treatment of Type 1 Diabetes [0.03%]
实现闭环（人工胰腺）系统以治疗1型糖尿病
Rayhan A Lal,Laya Ekhlaspour,Korey Hood et al.
Rayhan A Lal et al.
Recent, rapid changes in the treatment of type 1 diabetes have allowed for commercialization of an "artificial pancreas" that is better described as a closed-loop controller of insulin delivery. This review presents the current state of clo...
The Effects of Bariatric Surgery on Islet Function, Insulin Secretion, and Glucose Control [0.03%]
代谢手术对胰岛功能、胰岛素分泌和血糖控制的影响
Jonathan D Douros,Jenny Tong,David A D&#x;Alessio
Jonathan D Douros
Although bariatric surgery was developed primarily to treat morbid obesity, evidence from the earliest clinical observations to the most recent clinical trials consistently demonstrates that these procedures have substantial effects on gluc...
Delayed Puberty-Phenotypic Diversity, Molecular Genetic Mechanisms, and Recent Discoveries [0.03%]
延迟青春发育：表型多样性、分子遗传机制及最新研究进展
Sasha R Howard,Leo Dunkel
Sasha R Howard
This review presents a comprehensive discussion of the clinical condition of delayed puberty, a common presentation to the pediatric endocrinologist, which may present both diagnostic and prognostic challenges. Our understanding of the gene...
Richard I G Holt,Ken K Y Ho
Richard I G Holt
GH is banned by the World Anti-Doping Agency as a performance-enhancing anabolic agent. Doping with GH likely began in the early 1980s and became more prevalent with the advent of recombinant technology well before any scientific evidence o...
Zachary L Sebo,Elizabeth Rendina-Ruedy,Gene P Ables et al.
Zachary L Sebo et al.
The presence of adipocytes in mammalian bone marrow (BM) has been recognized histologically for decades, yet, until recently, these cells have received little attention from the research community. Advancements in mouse transgenics and imag...
Inflammation in the Pathophysiology and Therapy of Cardiometabolic Disease [0.03%]
炎症与心血管代谢性疾病的病理生理和治疗
Marc Y Donath,Daniel T Meier,Marianne Böni-Schnetzler
Marc Y Donath
The role of chronic inflammation in the pathogenesis of type 2 diabetes mellitus and associated complications is now well established. Therapeutic interventions counteracting metabolic inflammation improve insulin secretion and action and g...
The Liver as an Endocrine Organ-Linking NAFLD and Insulin Resistance [0.03%]
肝脏作为内分泌器官--非酒精性脂肪肝和胰岛素抵抗之间的联系
Matthew J Watt,Paula M Miotto,William De Nardo et al.
Matthew J Watt et al.
The liver is a dynamic organ that plays critical roles in many physiological processes, including the regulation of systemic glucose and lipid metabolism. Dysfunctional hepatic lipid metabolism is a cause of nonalcoholic fatty liver disease...
Clinical Guidelines and PTH Measurement: Does Assay Generation Matter? [0.03%]
临床指南与PTH检测：测定系统代际差异有无影响？
Marjon A Smit,Caroline M J van Kinschot,Joke van der Linden et al.
Marjon A Smit et al.
PTH is an important regulator of calcium and phosphate homeostasis and bone remodeling. It is metabolized into PTH fragments, which are measured to a different extent by PTH assays of different generations because of differences in fragment...
Marialetizia Rastelli,Patrice D Cani,Claude Knauf
Marialetizia Rastelli
The gut microbiome is considered an organ contributing to the regulation of host metabolism. Since the relationship between the gut microbiome and specific diseases was elucidated, numerous studies have deciphered molecular mechanisms expla...