Elisabetta Vegeto,Alessandro Villa,Sara Della Torre et al.
Elisabetta Vegeto et al.
Neurodegenerative diseases (NDs) are a wide class of disorders of the central nervous system (CNS) with unknown etiology. Several factors were hypothesized to be involved in the pathogenesis of these diseases, including genetic and environm...
Masaaki Yamamoto,Genzo Iguchi,Hironori Bando et al.
Masaaki Yamamoto et al.
Some endocrine disorders, including hypophysitis and isolated adrenocorticotropic hormone (ACTH) deficiency, are caused by an autoimmune response to endocrine organs. Although the pathogenesis of some autoimmune endocrine diseases has been ...
Progesterone and Breast Cancer [0.03%]
孕酮与乳腺癌
Britton Trabert,Mark E Sherman,Nagarajan Kannan et al.
Britton Trabert et al.
Synthetic progestogens (progestins) have been linked to increased breast cancer risk; however, the role of endogenous progesterone in breast physiology and carcinogenesis is less clearly defined. Mechanistic studies using cell culture, tiss...
Glucose-Dependent Insulinotropic Polypeptide Receptor Therapies for the Treatment of Obesity, Do Agonists = Antagonists? [0.03%]
胰高血糖素样肽-1受体药物治疗肥胖：激动剂=拮抗剂？
Elizabeth A Killion,Shu-Chen Lu,Madeline Fort et al.
Elizabeth A Killion et al.
Glucose-dependent insulinotropic polypeptide receptor (GIPR) is associated with obesity in human genome-wide association studies. Similarly, mouse genetic studies indicate that loss of function alleles and glucose-dependent insulinotropic p...
Glucose-Dependent Insulinotropic Polypeptide Receptor Therapies for the Treatment of Obesity, Do Agonists = Antagonists? [0.03%]
胰高血糖素样肽-1受体药物治疗肥胖：激动剂=拮抗剂？
Elizabeth A Killion,Shu-Chen Lu,Madeline Fort et al.
Elizabeth A Killion et al.
Glucose-dependent insulinotropic polypeptide receptor (GIPR) is associated with obesity in human genome-wide association studies. Similarly, mouse genetic studies indicate that loss of function alleles and glucose-dependent insulinotropic p...
Management of 46,XY Differences/Disorders of Sex Development (DSD) Throughout Life [0.03%]
46,XY性发育差异/性别发育 disorder(DSD)的终身管理
Amy B Wisniewski,Rafael L Batista,Elaine M F Costa et al.
Amy B Wisniewski et al.
Differences/disorders of sex development (DSD) are a heterogeneous group of congenital conditions that result in discordance between an individual's sex chromosomes, gonads, and/or anatomic sex. Advances in the clinical care of patients and...
Donald S A McLeod,Ling Zhang,Cosimo Durante et al.
Donald S A McLeod et al.
An ever-increasing population of patients with papillary thyroid cancer is engaging with health care systems around the world. Numerous questions about optimal management have arisen that challenge conventional paradigms. This is particular...
Miriam S Udler,Mark I McCarthy,Jose C Florez et al.
Miriam S Udler et al.
During the last decade, there have been substantial advances in the identification and characterization of DNA sequence variants associated with individual predisposition to type 1 and type 2 diabetes. As well as providing insights into the...
Targeted Therapy for Advanced Thyroid Cancer: Kinase Inhibitors and Beyond [0.03%]
甲状腺癌靶向治疗：激酶抑制剂及其他疗法
Maria E Cabanillas,Mabel Ryder,Camilo Jimenez
Maria E Cabanillas
The treatment of advanced thyroid cancer has undergone rapid evolution in the last decade, with multiple kinase inhibitor drug approvals for each subtype of thyroid cancer and a number of other commercially available drugs that have been st...
Steroid Metabolome Analysis in Disorders of Adrenal Steroid Biosynthesis and Metabolism [0.03%]
肾上腺皮质类固醇生物合成和代谢异常患者的类固醇代谢组分析
Karl-Heinz Storbeck,Lina Schiffer,Elizabeth S Baranowski et al.
Karl-Heinz Storbeck et al.
Steroid biosynthesis and metabolism are reflected by the serum steroid metabolome and, in even more detail, by the 24-hour urine steroid metabolome, which can provide unique insights into alterations of steroid flow and output indicative of...