Shana E McCormack,James E Blevins,Elizabeth A Lawson
Shana E McCormack
There is growing evidence that oxytocin (OXT), a hypothalamic hormone well recognized for its effects in inducing parturition and lactation, has important metabolic effects in both sexes. The purpose of this review is to summarize the physi...
Leptin: Is It Thermogenic? [0.03%]
瘦素具有生热作用吗？
Alexander W Fischer,Barbara Cannon,Jan Nedergaard
Alexander W Fischer
Animals that lack the hormone leptin become grossly obese, purportedly for 2 reasons: increased food intake and decreased energy expenditure (thermogenesis). This review examines the experimental evidence for the thermogenesis component. An...
Thyroid Hormone Transporters [0.03%]
甲状腺激素转运体
Stefan Groeneweg,Ferdy S van Geest,Robin P Peeters et al.
Stefan Groeneweg et al.
Thyroid hormone transporters at the plasma membrane govern intracellular bioavailability of thyroid hormone. Monocarboxylate transporter (MCT) 8 and MCT10, organic anion transporting polypeptide (OATP) 1C1, and SLC17A4 are currently known a...
Review: Diabetes, Obesity, and Cancer-Pathophysiology and Clinical Implications [0.03%]
糖尿病、肥胖和癌症：病理生理学及临床意义述评
Iliana C Lega,Lorraine L Lipscombe
Iliana C Lega
Obesity and diabetes have both been associated with an increased risk of cancer. In the face of increasing obesity and diabetes rates worldwide, this is a worrying trend for cancer rates. Factors such as hyperinsulinemia, chronic inflammati...
Stem Leydig Cells in the Adult Testis: Characterization, Regulation and Potential Applications [0.03%]
成人睾丸干细胞-莱迪基细胞：特征、调控及潜在应用
Panpan Chen,Barry R Zirkin,Haolin Chen
Panpan Chen
Androgen deficiency (hypogonadism) affects males of all ages. Testosterone replacement therapy (TRT) is effective in restoring serum testosterone and relieving symptoms. TRT, however, is reported to have possible adverse effects in part bec...
Fibrous Dysplasia/McCune-Albright Syndrome: A Rare, Mosaic Disease of Gα s Activation [0.03%]
纤维发育不全/麦卡恩-阿尔布赖特综合征：一种罕见的Gαs活化嵌合体疾病
Alison M Boyce,Michael T Collins
Alison M Boyce
Fibrous dysplasia/McCune-Albright syndrome (FD/MAS) is a rare disorder of striking complexity. It arises from somatic, gain-of-function mutations in GNAS, leading to mosaic Gα s activation and inappropriate production of intracellular cycl...
Camilla Scheele,Christian Wolfrum
Camilla Scheele
Infants rely on brown adipose tissue (BAT) as a primary source of thermogenesis. In some adult humans, residuals of brown adipose tissue are adjacent to the central nervous system and acute activation increases metabolic rate. Brown adipose...
The New Biology of Diabetic Kidney Disease-Mechanisms and Therapeutic Implications [0.03%]
糖尿病肾病的新生物学机制及治疗意义
Yuliya Lytvyn,Petter Bjornstad,Daniel H van Raalte et al.
Yuliya Lytvyn et al.
Diabetic kidney disease remains the most common cause of end-stage kidney disease in the world. Despite reductions in incidence rates of myocardial infarction and stroke in people with diabetes over the past 3 decades, the risk of diabetic ...
Nonalcoholic Fatty Liver Disease in Adults: Current Concepts in Etiology, Outcomes, and Management [0.03%]
成人非酒精性脂肪肝病的病因、转归和治疗概念进展
Thomas Marjot,Ahmad Moolla,Jeremy F Cobbold et al.
Thomas Marjot et al.
Nonalcoholic fatty liver disease (NAFLD) is a spectrum of disease, extending from simple steatosis to inflammation and fibrosis with a significant risk for the development of cirrhosis. It is highly prevalent and is associated with signific...
Advances in the Diagnosis and Management of Well-Differentiated Neuroendocrine Neoplasms [0.03%]
神经内分泌肿瘤的诊断和治疗进展
Johannes Hofland,Gregory Kaltsas,Wouter W de Herder
Johannes Hofland
Neuroendocrine neoplasms constitute a diverse group of tumors that derive from the sensory and secretory neuroendocrine cells and predominantly arise within the pulmonary and gastrointestinal tracts. The majority of these neoplasms have a w...