Maria Luisa Brandi,Sunita K Agarwal,Nancy D Perrier et al.
Maria Luisa Brandi et al.
Multiple endocrine neoplasia type 1 (MEN1), a rare tumor syndrome that is inherited in an autosomal dominant pattern, is continuing to raise great interest for endocrinology, gastroenterology, surgery, radiology, genetics, and molecular bio...
Progress in Translational Regulatory T Cell Therapies for Type 1 Diabetes and Islet Transplantation [0.03%]
1型糖尿病和胰岛移植的转化调节性T细胞治疗进展
Braulio A Marfil-Garza,Joshua Hefler,Mario Bermudez De Leon et al.
Braulio A Marfil-Garza et al.
Regulatory T cells (Tregs) have become highly relevant in the pathophysiology and treatment of autoimmune diseases, such as type 1 diabetes (T1D). As these cells are known to be defective in T1D, recent efforts have explored ex vivo and in ...
Mamatha Bhat,Shirine E Usmani,Amirhossein Azhie et al.
Mamatha Bhat et al.
Metabolic complications affect over 50% of solid organ transplant recipients. These include posttransplant diabetes, nonalcoholic fatty liver disease, dyslipidemia, and obesity. Preexisting metabolic disease is further exacerbated with immu...
Sandra Pereira,Daemon L Cline,Maria M Glavas et al.
Sandra Pereira et al.
The discovery of leptin was intrinsically associated with its ability to regulate body weight. However, the effects of leptin are more far-reaching and include profound glucose-lowering and anti-lipogenic effects, independent of leptin's re...
Microvascular Dysfunction in Diabetes Mellitus and Cardiometabolic Disease [0.03%]
糖尿病和心血管代谢性疾病中的微血管功能障碍
William B Horton,Eugene J Barrett
William B Horton
This review takes an inclusive approach to microvascular dysfunction in diabetes mellitus and cardiometabolic disease. In virtually every organ, dynamic interactions between the microvasculature and resident tissue elements normally modulat...
Xiaoming Hu,Feifan Guo
Xiaoming Hu
Sensing and responding to changes in nutrient levels, including those of glucose, lipids, and amino acids, by the body is necessary for survival. Accordingly, perturbations in nutrient sensing are tightly linked with human pathologies, part...
Traci E LaMoia,Gerald I Shulman
Traci E LaMoia
Metformin is a first-line therapy for the treatment of type 2 diabetes, due to its robust glucose-lowering effects, well-established safety profile, and relatively low cost. While metformin has been shown to have pleotropic effects on gluco...
Laura C Lane,Tim D Cheetham,Petros Perros et al.
Laura C Lane et al.
Graves' hyperthyroidism is characterized by the presence of autoantibodies that stimulate the thyroid-stimulating hormone receptor (TSHR), resulting in uncontrolled secretion of excessive thyroid hormone. Conventional treatments, including ...