The impact of estrogen deficiency on liver metabolism; implications for hormone replacement therapy [0.03%]
雌激素缺乏对肝脏代谢的影响；荷尔蒙替代疗法的含义
Jiawen Dong,Kaitlyn M J H Dennis,Radha Venkatakrishnan et al.
Jiawen Dong et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD, previously NAFLD) is the most common chronic liver condition globally. It affects 1-in-3 individuals and is associated with increased liver and cardiovascular mortality. MASLD...
Natasha Maria James,Kristin I Stanford
Natasha Maria James
Obesity is increasing rapidly worldwide and is projected to affect approximately half the U.S. population by the year 2035. Obesity is a complex condition, and individuals who have obesity are at greater risk for developing associated metab...
Katja Petrowski,George J Kahaly
Katja Petrowski
Experimental animal and human studies illustrate the effect of various stress forms on the thyroid gland and the regulation of thyroid hormones (TH) through the thyrotropic multi-loop control circuit. The hypothalamic-pituitary-thyroid axis...
Contraceptive Selection for the Endocrine Patient: What an Endocrinologist Should Know [0.03%]
内分泌患者的避孕选择：内分泌科医生需要了解什么
Adnin Zaman,Aaron Lazorwitz,Margaret E Wierman
Adnin Zaman
Although endocrinologists specialize in the management of hormones, they often lack sufficient training in the appropriate use of the diverse array of available contraceptive options. All medical providers should possess a fundamental under...
The Roles of Natural Killer Cells in Breast Cancer Pathobiology and their Regulation by Estrogens [0.03%]
自然杀伤细胞在乳腺癌病理生物学中的作用及其活性的雌激素调节机制研究
Jovita Byemerwa,Ching-Yi Chang,Donald P McDonnell
Jovita Byemerwa
Breast cancer remains the most commonly diagnosed malignancy among women worldwide. While breast cancer treatment outcomes have improved in recent years there remains an unmet medical need for therapeutics that can be used with curative int...
Lu Wang,Le Chang,Yufei Ma et al.
Lu Wang et al.
Skeletal muscle insulin resistance (IR) is a critical deficiency in IR pathophysiology that significantly affects overall metabolic health. Skeletal muscle is mechanically sensitive since its structure and function are significantly influen...
The Chronobiology of Hormone Administration: "Doctor, what time should I take my medication?" [0.03%]
激素给药的时间医学：“医生，我什么时候吃药比较好？”
Elena Colonnello,Andrea Graziani,Rebecca Rossetti et al.
Elena Colonnello et al.
Pharmacotherapy involving hormones and hormone-derived molecules has various potential treatment targets. This includes addressing (partial) hormonal deficiencies, pursuing osteoanabolic effects, providing contraceptive options, or supporti...
Epidemiology, genetic etiology and intervention of premature ovarian insufficiency [0.03%]
早发性卵巢功能不全的流行病学、遗传病因及干预措施研究进展
Ting Guo,Hongyuan Liu,Bingying Xu et al.
Ting Guo et al.
Premature ovarian insufficiency (POI) is a highly heterogeneous reproductive disorder in both its etiology and clinical presentation. The epidemiological characteristics of POI suggest that its occurrence likely involves a combination of ge...
Bone in parathyroid diseases revisited: evidence from epidemiological, surgical and new drug outcomes [0.03%]
从流行病学、外科和新型药物结局证据重新审视甲状旁腺疾病中的骨骼问题
Afroditi Roumpou,Andrea Palermo,Symeon Tournis et al.
Afroditi Roumpou et al.
Parathyroid hormone (PTH)-related disorders have a major impact on bone metabolism and skeletal properties, due to the pivotal role of PTH in calcium and phosphate homeostasis and bone remodeling.Hyperparathyroidism is characterized by cont...
Historical aspects of testicular function: virility, androgen production and spermatogenesis [0.03%]
睾丸功能的历史方面：雄性特征，雄激素产生和精子发生
Alan D Rogol,Marco Cappa
Alan D Rogol
From antiquity, Man has been fascinated by at least two processes of testicular function: virility and reproduction; their biological basis was uncovered beginning in the mid-19th century. We have divided the search into 3 epochs: the specu...