Advances in Type 1 Diabetes Prediction Using Islet Autoantibodies: Beyond a Simple Count [0.03%]
利用胰岛自身抗体预测1型糖尿病的新进展：简单计数之外的事物
Michelle So,Cate Speake,Andrea K Steck et al.
Michelle So et al.
Islet autoantibodies are key markers for the diagnosis of type 1 diabetes. Since their discovery, they have also been recognized for their potential to identify at-risk individuals prior to symptoms. To date, risk prediction using autoantib...
Hormone Therapy in Menopause: Concepts, Controversies, and Approach to Treatment [0.03%]
围绝经期激素治疗的概念、争议及处理原则
Valerie A Flores,Lubna Pal,JoAnn E Manson
Valerie A Flores
Hormone therapy (HT) is an effective treatment for menopausal symptoms, including vasomotor symptoms and genitourinary syndrome of menopause. Randomized trials also demonstrate positive effects on bone health, and age-stratified analyses in...
Nathalie di Clemente,Chrystèle Racine,Alice Pierre et al.
Nathalie di Clemente et al.
Anti-Müllerian hormone (AMH), also called Müllerian inhibiting substance, was shown to be synthesized by the ovary in the 1980s. This article reviews the main findings of the past 20 years on the regulation of the expression of AMH and it...
John T Walker,Diane C Saunders,Marcela Brissova et al.
John T Walker et al.
This review focuses on the human pancreatic islet-including its structure, cell composition, development, function, and dysfunction. After providing a historical timeline of key discoveries about human islets over the past century, we descr...
Robert L Rosenfield
Robert L Rosenfield
Adrenarche is the maturational increase in adrenal androgen production that normally begins in early childhood. It results from changes in the secretory response to adrenocorticotropin (ACTH) that are best indexed by dehydroepiandrosterone ...
Multi-organ Coordination of Lipoprotein Secretion by Hormones, Nutrients and Neural Networks [0.03%]
激素、营养物质和神经网络对脂蛋白分泌的多器官协调作用
Priska Stahel,Changting Xiao,Avital Nahmias et al.
Priska Stahel et al.
Plasma triglyceride-rich lipoproteins (TRL), particularly atherogenic remnant lipoproteins, contribute to atherosclerotic cardiovascular disease. Hypertriglyceridemia may arise in part from hypersecretion of TRLs by the liver and intestine....
Conducting Real-world Evidence Studies on the Clinical Outcomes of Diabetes Treatments [0.03%]
真实世界证据在糖尿病治疗临床效果研究中的应用
Sebastian Schneeweiss,Elisabetta Patorno
Sebastian Schneeweiss
Real-world evidence (RWE), the understanding of treatment effectiveness in clinical practice generated from longitudinal patient-level data from the routine operation of the healthcare system, is thought to complement evidence on the effica...
Considering Sex as a Biological Variable in Basic and Clinical Studies: An Endocrine Society Scientific Statement [0.03%]
从基础和临床研究角度考虑性别作为生物学变量：内分泌协会科学声明
Aditi Bhargava,Arthur P Arnold,Debra A Bangasser et al.
Aditi Bhargava et al.
In May 2014, the National Institutes of Health (NIH) stated its intent to "require applicants to consider sex as a biological variable (SABV) in the design and analysis of NIH-funded research involving animals and cells." Since then, propos...
ER Stress in Cardiometabolic Diseases: From Molecular Mechanisms to Therapeutics [0.03%]
心元代谢病中的内质网应激：从分子机制到治疗措施
Amir Ajoolabady,Shuyi Wang,Guido Kroemer et al.
Amir Ajoolabady et al.
The endoplasmic reticulum (ER) hosts linear polypeptides and fosters natural folding of proteins through ER-residing chaperones and enzymes. Failure of the ER to align and compose proper protein architecture leads to accumulation of misfold...
Physiological and Pharmacological Roles of PTH and PTHrP in Bone Using Their Shared Receptor, PTH1R [0.03%]
通过其共同受体PTH1R探讨PTH和PTHrP在骨组织中的生理及药理作用
T John Martin,Natalie A Sims,Ego Seeman
T John Martin
Parathyroid hormone (PTH) and the paracrine factor, PTH-related protein (PTHrP), have preserved in evolution sufficient identities in their amino-terminal domains to share equivalent actions upon a common G protein-coupled receptor, PTH1R, ...