Nabil G Seidah,Annik Prat
Nabil G Seidah
This article reviews the discovery of PCSK9, its structure-function characteristics, and its presently known and proposed novel biological functions. The major critical function of PCSK9 deduced from human and mouse studies, as well as cell...
Nabil G Seidah,Annik Prat
Nabil G Seidah
This article reviews the discovery of PCSK9, its structure-function characteristics, and its presently known and proposed novel biological functions. The major critical function of PCSK9 deduced from human and mouse studies, as well as cell...
Update on Biology and Genomics of Adrenocortical Carcinomas: Rationale for Emerging Therapies [0.03%]
肾上腺皮质癌的生物学和基因组学最新研究进展：新兴疗法的应用前景
Antonio Marcondes Lerario,Dipika R Mohan,Gary D Hammer
Antonio Marcondes Lerario
The adrenal glands are paired endocrine organs that produce steroid hormones and catecholamines required for life. Adrenocortical carcinoma (ACC) is a rare and often fatal cancer of the peripheral domain of the gland, the adrenal cortex. Re...
Peptidergic G Protein-Coupled Receptor Regulation of Adrenal Function: Bench to Bedside and Back [0.03%]
肽类G蛋白偶联受体对肾上腺功能调节的作用：从实验到临床和回归实验室
Livia Lenzini,Brasilina Caroccia,Teresa Maria Seccia et al.
Livia Lenzini et al.
An altered secretion of adrenocortical and adrenomedullary hormones plays a role in the clinical syndromes of primary aldosteronism (PA), Cushing, and pheochromocytoma. Moreover, an altered production of adrenocortical hormones and/or an ab...
Shlomo Melmed,Ursula B Kaiser,M Beatriz Lopes et al.
Shlomo Melmed et al.
All endocrine glands are susceptible to neoplastic growth, yet the health consequences of these neoplasms differ between endocrine tissues. Pituitary neoplasms are highly prevalent and overwhelmingly benign, exhibiting a spectrum of diverse...
The Weight of Place: Built Environment Correlates of Obesity and Diabetes [0.03%]
Built environment与肥胖和糖尿病的关联性研究
Nicholas A Howell,Gillian L Booth
Nicholas A Howell
In recent decades, the prevalence of obesity and diabetes has risen substantially in North America and worldwide. To address these dual epidemics, researchers and policymakers alike have been searching for effective means to promote healthy...
Fracture Healing in the Setting of Endocrine Diseases, Aging, and Cellular Senescence [0.03%]
内分泌疾病、衰老和细胞衰老情况下的骨折愈合
Dominik Saul,Sundeep Khosla
Dominik Saul
More than 2.1 million age-related fractures occur in the United States annually, resulting in an immense socioeconomic burden. Importantly, the age-related deterioration of bone structure is associated with impaired bone healing. Fracture h...
Louise E Olofsson,Fredrik Bäckhed
Louise E Olofsson
We are host to an assembly of microorganisms that vary in structure and function along the length of the gut and from the lumen to the mucosa. This ecosystem is collectively known as the gut microbiota and significant efforts have been spen...