A Century-long Journey From the Discovery of Insulin to the Implantation of Stem Cell-derived Islets [0.03%]
从胰岛素发现之旅到干细胞来源胰岛植入の百年历程
Adam Ramzy,Paul J Belmonte,Mitchell J S Braam et al.
Adam Ramzy et al.
For the past century, insulin injections have saved millions of lives, but glycemic instability is still a persistent challenge for people with diabetes, leading to tremendous morbidity and premature mortality. Research in the field of isle...
Consensus Recommendations for the Use of Automated Insulin Delivery Technologies in Clinical Practice [0.03%]
自动胰岛素输送技术的临床应用共识建议
Moshe Phillip,Revital Nimri,Richard M Bergenstal et al.
Moshe Phillip et al.
The significant and growing global prevalence of diabetes continues to challenge people with diabetes (PwD), healthcare providers, and payers. While maintaining near-normal glucose levels has been shown to prevent or delay the progression o...
History of Adrenal Research: From Ancient Anatomy to Contemporary Molecular Biology [0.03%]
肾上腺研究的历史：从古解剖学到现代分子生物学
Walter L Miller,Perrin C White
Walter L Miller
The adrenal is a small, anatomically unimposing structure that escaped scientific notice until 1564 and whose existence was doubted by many until the 18th century. Adrenal functions were inferred from the adrenal insufficiency syndrome desc...
The Congenital and Acquired Mechanisms Implicated in the Etiology of Central Precocious Puberty [0.03%]
中枢性早熟的病因涉及的先天性和获得性机制
Vinicius N Brito,Ana P M Canton,Carlos Eduardo Seraphim et al.
Vinicius N Brito et al.
The etiology of central precocious puberty (CPP) is multiple and heterogeneous, including congenital and acquired causes that can be associated with structural or functional brain alterations. All causes of CPP culminate in the premature pu...
Glucagon-like Peptide-1 Receptor-based Therapeutics for Metabolic Liver Disease [0.03%]
基于胰高糖素样肽-1受体的代谢性肝病治疗药物
Julian M Yabut,Daniel J Drucker
Julian M Yabut
Glucagon-like peptide-1 (GLP-1) controls islet hormone secretion, gut motility, and body weight, supporting development of GLP-1 receptor agonists (GLP-1RA) for the treatment of type 2 diabetes (T2D) and obesity. GLP-1RA exhibit a favorable...
Binita Chakraborty,Jovita Byemerwa,Taylor Krebs et al.
Binita Chakraborty et al.
The immune system functions in a sexually dimorphic manner, with females exhibiting more robust immune responses than males. However, how female sex hormones affect immune function in normal homeostasis and in autoimmunity is poorly underst...
Claus H Gravholt,Mette Viuff,Jesper Just et al.
Claus H Gravholt et al.
Turner syndrome (TS) is a condition in females missing the second sex chromosome (45,X) or parts thereof. It is considered a rare genetic condition and is associated with a wide range of clinical stigmata, such as short stature, ovarian dys...
André C Carpentier,Denis P Blondin,François Haman et al.
André C Carpentier et al.
Brown adipose tissue (BAT) displays the unique capacity to generate heat through uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for cardiometabolic diseases. Here, we review BAT cellular metabolism, i...
Management of Growth Disorders in Puberty: GH, GnRHa, and Aromatase Inhibitors: A Clinical Review [0.03%]
青春期生长障碍的管理：GH、GnRHa和芳香化酶抑制剂：临床综述
Nelly Mauras,Judith Ross,Veronica Mericq
Nelly Mauras
Pubertal children with significant growth retardation represent a considerable therapeutic challenge. In growth hormone (GH) deficiency, and in those without identifiable pathologies (idiopathic short stature), the impact of using GH is sig...
Hippo Signaling in the Ovary: Emerging Roles in Development, Fertility, and Disease [0.03%]
卵巢的哺乳动物Hippo信号通路：在发育、生殖和疾病中的新角色
Kendra L Clark,Jitu W George,Emilia Przygrodzka et al.
Kendra L Clark et al.
Emerging studies indicate that the Hippo pathway, a highly conserved pathway that regulates organ size control, plays an important role in governing ovarian physiology, fertility, and pathology. Specific to the ovary, the spatiotemporal exp...