Marian Schini,Tatiane Vilaca,Fatma Gossiel et al.
Marian Schini et al.
Bone turnover markers (BTMs) are used widely, in both research and clinical practice. In the last 20 years, much experience has been gained in measurement and interpretation of these markers, which include commonly used bone formation marke...
Molecular Mechanisms of PTH/PTHrP Class B GPCR Signaling and Pharmacological Implications [0.03%]
PTH / PTHrP 类 B GPCR 信号转导的分子机制及其药理学意义
Jean-Pierre Vilardaga,Lisa J Clark,Alex D White et al.
Jean-Pierre Vilardaga et al.
The classical paradigm of G protein-coupled receptor (GPCR) signaling via G proteins is grounded in a view that downstream responses are relatively transient and confined to the cell surface, but this notion has been revised in recent years...
Hanqing Liu,Wei Li,Wen Zhang et al.
Hanqing Liu et al.
Although levothyroxine is one of the most prescribed medications in the world, its bioavailability has been reported to be impaired by many factors, including interfering drugs or foods and concomitant diseases, and persistent hypothyroidis...
Michael Nyberg,Dijana Terzic,Trine P Ludvigsen et al.
Michael Nyberg et al.
Measurement of natriuretic peptides (NPs) has proven its clinical value as biomarker, especially in the context of heart failure (HF). In contrast, a state of partial NP deficiency appears integral to several conditions in which lower NP co...
Lynette J Oost,Cees J Tack,Jeroen H F de Baaij
Lynette J Oost
Hypomagnesemia is 10-fold more common in individuals with type 2 diabetes (T2D) than in the healthy population. Factors that are involved in this high prevalence are low Mg2+ intake, gut microbiome composition, medication use, and presumabl...
Salvatore Minisola,Seiji Fukumoto,Weibo Xia et al.
Salvatore Minisola et al.
Tumor-induced osteomalacia (TIO) is an ultrarare paraneoplastic syndrome due to overproduction of fibroblast growth factor 23 (FGF23), with profound effects on patient morbidity. TIO is an underdiagnosed disease, whose awareness should be i...
Hypoxia-Inducible Factor 2 Alpha (HIF2α) Inhibitors: Targeting Genetically Driven Tumor Hypoxia [0.03%]
缺氧诱导因子2α(HIF2α)抑制剂：靶向遗传驱动的肿瘤缺氧
Rodrigo A Toledo,Camilo Jimenez,Gustavo Armaiz-Pena et al.
Rodrigo A Toledo et al.
Tumors driven by deficiency of the VHL gene product, which is involved in degradation of the hypoxia-inducible factor subunit 2 alpha (HIF2α), are natural candidates for targeted inhibition of this pathway. Belzutifan, a highly specific an...
Biological and Therapeutic Implications of the Tumor Microenvironment in Pituitary Adenomas [0.03%]
垂体腺瘤的肿瘤微环境的生物学和治疗意义
Mirela-Diana Ilie,Alexandre Vasiljevic,Philippe Bertolino et al.
Mirela-Diana Ilie et al.
Pituitary adenomas (PAs) are neoplasms derived from the endocrine cells of the anterior pituitary gland. Most frequently, they are benign tumors, but may sometimes display an aggressive course, and in some cases metastasize. Their biology, ...
The Significance of Hypothalamic Inflammation and Gliosis for the Pathogenesis of Obesity in Humans [0.03%]
人类下丘脑炎症和星形胶质细胞增生对肥胖发病机制的意义
Leticia E Sewaybricker,Alyssa Huang,Suchitra Chandrasekaran et al.
Leticia E Sewaybricker et al.
Accumulated preclinical literature demonstrates that hypothalamic inflammation and gliosis are underlying causal components of diet-induced obesity in rodent models. This review summarizes and synthesizes available translational data to bet...