Advances in the Treatment of Gastroenteropancreatic Neuroendocrine Carcinomas: Are we Moving Forward? [0.03%]
胃肠胰神经内分泌癌的治疗进展：我们在前进吗？
Rocio Garcia-Carbonero,Beatriz Anton-Pascual,Andrea Modrego et al.
Rocio Garcia-Carbonero et al.
Poorly differentiated gastroenteropancreatic neuroendocrine carcinomas are aggressive neoplasms of challenging clinical management. A small proportion of patients with early-stage disease may achieve long-term survival, but the majority of ...
Insulin/IGF Axis and the Receptor for Advanced Glycation End Products: Role in Meta-inflammation and Potential in Cancer Therapy [0.03%]
胰岛素/IGF轴和晚期糖基化终产物受体在元炎症中的作用及其在癌症治疗中的潜力
Veronica Vella,Rosamaria Lappano,Eduardo Bonavita et al.
Veronica Vella et al.
In metabolic conditions such as obesity and diabetes, which are associated with deregulated signaling of the insulin/insulin-like growth factor system (IIGFs), inflammation plays a dominant role. In cancer, IIGFs is implicated in disease pr...
Ningning Zhang,Mingyang Yuan,Jiqiu Wang
Ningning Zhang
Classic hormone membrane receptors, such as leucine-rich repeat-containing G protein-coupled receptor (LGR) 1 (follicle-stimulating hormone receptor), LGR2 (luteinizing hormone receptor), and LGR3 (thyrotropin receptor), are crucial in endo...
Intracellular to Interorgan Mitochondrial Communication in Striated Muscle in Health and Disease [0.03%]
健康与疾病状态下骨骼肌细胞内线粒体交流机制
Neoma T Boardman,Giulia Trani,Marco Scalabrin et al.
Neoma T Boardman et al.
Mitochondria sense both biochemical and energetic input in addition to communicating signals regarding the energetic state of the cell. Increasingly, these signaling organelles are recognized as key for regulating different cell functions. ...
International Consensus Guideline on Small for Gestational Age: Etiology and Management From Infancy to Early Adulthood [0.03%]
国际共识指南：从婴儿期到早年成人的宫内生长受限的病因及处理方法
Anita C S Hokken-Koelega,Manouk van der Steen,Margaret C S Boguszewski et al.
Anita C S Hokken-Koelega et al.
This International Consensus Guideline was developed by experts in the field of small for gestational age (SGA) of 10 pediatric endocrine societies worldwide. A consensus meeting was held and 1300 articles formed the basis for discussions. ...
Recent Advances in the Role of Autophagy in Endocrine-Dependent Tumors [0.03%]
自噬在内分泌依赖性肿瘤中的作用的最新研究进展
Anvita Komarla,Suzanne Dufresne,Christina G Towers
Anvita Komarla
Autophagy plays a complex role in several cancer types, including endocrine-dependent cancers, by fueling cellular metabolism and clearing damaged substrates. This conserved recycling process has a dual function across tumor types where it ...
Contemporary Biological Insights and Clinical Management of Craniopharyngioma [0.03%]
颅咽管瘤的当代生物学见解及其临床治疗管理
John Richard Apps,Hermann Lothar Muller,Todd Cameron Hankinson et al.
John Richard Apps et al.
Craniopharyngiomas (CPs) are clinically aggressive tumors because of their invasive behavior and recalcitrant tendency to recur after therapy. There are 2 types based on their distinct histology and molecular features: the papillary craniop...
Clinical, Pathophysiologic, Genetic, and Therapeutic Progress in Primary Bilateral Macronodular Adrenal Hyperplasia [0.03%]
原发性双侧肾上腺大结节增生的临床、病理生理、基因及治疗进展
Jérôme Bertherat,Isabelle Bourdeau,Lucas Bouys et al.
Jérôme Bertherat et al.
Patients with primary bilateral macronodular adrenal hyperplasia (PBMAH) usually present bilateral benign adrenocortical macronodules at imaging and variable levels of cortisol excess. PBMAH is a rare cause of primary overt Cushing's syndro...
Brian P Cary,Xin Zhang,Jianjun Cao et al.
Brian P Cary et al.
G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors. Class B1 GPCRs constitute a subfamily of 15 receptors that characteristically contain large extracellular domains (ECDs) and respond to long polypeptide h...