Innovative molecules and delivery technologies enabling the future of GLP-1-based therapies [0.03%]
创新分子和递送技术赋能的GLP-1基治疗药物的未来
Yining Xu,Daniel J Drucker,Giovanni Traverso et al.
Yining Xu et al.
The multiple physiological effects of gut hormones in different metabolic tissues make them attractive therapeutic targets for the treatment of metabolic diseases. Currently, only GLP-1 receptor-based agonists and oral DPP-4 inhibitors are ...
Anna Claire G Fernandez,Sanika Pelnekar,Joshua F Robinson et al.
Anna Claire G Fernandez et al.
Climate change is a major threat to the world's population and is due to global warming from human activities that increase atmospheric greenhouse gas levels -burning fossil fuels, industry emissions, vehicular exhaust, and aerosol chlorofl...
Management of Acquired Hypothalamic Dysfunction and the Hypothalamic Syndrome; it is more than obesity [0.03%]
获得性下丘脑功能障碍和下丘脑综合征的管理；不仅仅是肥胖的问题
Hanneke M van Santen,Hermann L Müller
Hanneke M van Santen
The hypothalamus is the key regulator of the human energy's balance. Hypothalamic dysfunction leads to (morbid) hypothalamic obesity, but may have many more consequences such as hypopituitarism, adipsia, disruption of the circadian rhythm, ...
Opposing Metabolic Effects of Growth Hormone and IGF-I: Review and Clinical Implications [0.03%]
生长激素和IGF-I的拮抗代谢效应：综述与临床意义
Zvi Laron,Haim Werner
Zvi Laron
The growth hormone (GH)-insulin-like growth factor-I (IGF-I) endocrine system has a central role in metabolism and growth. The Somatomedin Hypothesis, postulated in the mid-1950s, claimed that the biological activities of pituitary GH are m...
A critical assessment of fasting to promote metabolic health and longevity [0.03%]
评估禁食对促进代谢健康和长寿的影响
Pouneh K Fazeli,Matthew L Steinhauser
Pouneh K Fazeli
The adaptive starvation response allows us to survive periods of starvation - a characteristic of the environment in which humans evolved. We are now in an evolutionary transition from a global environment which was characterized by periods...
Medical Treatment of Acromegaly: Navigating the Present, Shaping the Future [0.03%]
肢端肥大症的药物治疗：盘点现状，展望未来
Mônica R Gadelha,Luiz Eduardo Wildemberg,Nelma Veronica Marques et al.
Mônica R Gadelha et al.
Acromegaly is a chronic systemic disease associated with significant morbidity due to its many complications, which lead to increased mortality rates. Adequate treatment is essential to reduce the development of long-term complications and ...
G-protein coupled & membrane tyrosine kinase receptors relationship yield therapy opportunities [0.03%]
G蛋白偶联受体与酪氨酸激酶跨膜受体的关系产生新的治疗机会
Leonard Girnita,Joseph A M J L Janssen,Terry J Smith
Leonard Girnita
The aim of this review is to describe the complex evolutionary processes that have integrated signaling cascades associated with two structurally and mechanistically dissimilar receptor families: G protein coupled receptors (GPCRs) and memb...