SSTR-Based Therapies for Gastroenteropancreatic and Thoracic Neuroendocrine Neoplasms [0.03%]
基于SSTR的胃肠道和胸部神经内分泌肿瘤治疗
Simona Grozinsky-Glasberg,Beata Kos-Kudla
Simona Grozinsky-Glasberg
Somatostatin (SRIF) and its receptors (SSTR) are key players in the regulation of neuroendocrine neoplasms (NEN), with significant implications for diagnosis, prognosis and treatment. The field of SSTR-targeted drugs/ligands (SRL) is contin...
Ian R Reid,Mark J Bolland
Ian R Reid
Postmenopausal women experience ongoing loss of bone mass, with resulting increases in the risk of fracture. This review describes the nature of postmenopausal bone loss, the definition of osteoporosis, and the current status of fracture ri...
Steroid Receptor Coactivators - From Basic Research to Translational Opportunities [0.03%]
从基础研究到转化应用：甾体受体共激活因子的研究进展
Yosef Gilad,Sang Jun Han,David M Lonard
Yosef Gilad
The concept of nuclear receptor (NR) coregulation was proposed nearly two decades before it was experimentally validated. According to this model, NRs - executors of a vast array of transcriptional programs - do not act independently but ar...
Eduardo C Lobato,Andre F Lafranchi,Felipe Freitas-Castro et al.
Eduardo C Lobato et al.
Epigenetic regulation, including DNA methylation, histone modifications, non-coding RNAs, and higher-order chromatin remodeling, plays a central role in the biology of neuroendocrine neoplasms (NENs). Advances in high-throughput profiling h...
Vitamin D and Uterine Fibroids: Insights into Pathophysiology and Therapeutic Potential [0.03%]
维生素D和子宫肌瘤：病理生理学和治疗潜力的见解
Michał Ciebiera,Elżbieta Zarychta,Natalia Żeber-Lubecka et al.
Michał Ciebiera et al.
Uterine fibroids (UFs) are highly prevalent benign tumors, primarily affecting women of reproductive age. The prevalence of UFs is estimated at 25% to 70% to 80%, with significantly higher rates among African women. Recent investigations ha...
Patrick Murphy,Adam Mitchell,David Edge et al.
Patrick Murphy et al.
Radiotherapy has a key role in the management of pituitary tumours as well as other benign and malignant disease that occurs anatomically close to the pituitary gland. The role of radiotherapy in these diseases is outlined in this review, a...
Timothy D Noakes,Philip J Prins,Alex Buga et al.
Timothy D Noakes et al.
Carbohydrate (CHO) ingestion during exercise has long been associated with improved performance. Early Scandinavian research proposed that CHO ingestion mitigates exercise-induced hypoglycemia (EIH) through a central neural mechanism, preve...
Anna Koumarianou,Jules Derks,Marina Tsoli et al.
Anna Koumarianou et al.
This narrative review written by experts aims to provide a comprehensive synthesis of current knowledge and guidelines on lung carcinoids, emphasizing the multidimensional approach required for effective diagnosis and management. The manusc...
Update and practical recommendations for the use of medical treatment of Cushing´s syndrome [0.03%]
库欣综合征的医学治疗更新及实用建议
Marta Araujo-Castro,Cristina Lamas,Elisabeth Nowak et al.
Marta Araujo-Castro et al.
Medical treatment of hypercortisolism may be necessary for a high proportion of patients with Cushing´s syndrome (CS), including those who are not candidates for curative surgery. It may also be used in the presurgical period when hypercor...
Mechanisms of Testosterone's Anabolic Effects on Muscle and Function: Controversies and New Insights [0.03%]
睾酮的促肌肉生长作用机制：争议与新见解
Shalender Bhasin,Chengzhi Wang,Mohan S Chandra et al.
Shalender Bhasin et al.
Testosterone treatment increases muscle mass, maximal voluntary muscle-strength, aerobic capacity, and some measures of physical function. Activational and epigenetic mechanisms by which androgens improve muscle mass and physical performanc...