Development and Characterization of a Long-Acting Allosteric Growth Hormone Receptor Antagonist for Acromegaly [0.03%]
长效别构生长激素受体拮抗剂的开发及特性表征用于肢端肥大症治疗
Katherine Kurylo,Page R Bouchard,Mark N Milton et al.
Katherine Kurylo et al.
Acromegaly is a rare disease caused by growth hormone (GH) hypersecretion from a pituitary adenoma. Pegvisomant is the only approved GH receptor antagonist (GHRA) and is administered via daily subcutaneous injections, which limits real-worl...
New insights into SREB orphan receptor roles in the ovary, using comparative transcriptomics across three fishes [0.03%]
比较转录组学揭示鱼类SREBP孤儿受体在卵巢中的新作用
Charles Heyder,Casey A Murray,Philip Ganith et al.
Charles Heyder et al.
Super-conserved Receptors Expressed in Brain (SREB) are a family of orphan G protein coupled receptors with three members in most vertebrates (GPR27 or SREB1, GPR85 or SREB2, and GPR173 or SREB3). They are associated with diverse physiologi...
Physical activity and human IAPP islet amyloidosis: mechanistic plausibility, missing evidence, and future directions [0.03%]
运动与人胰岛淀粉样多肽胰岛淀粉样变性的机制合理性、缺失的证据及未来方向
Joan-Marc Servitja,Anna Novials,Joel Montane
Joan-Marc Servitja
Islet amyloid deposition derived from human islet amyloid polypeptide (hIAPP, amylin) is a hallmark of type 2 diabetes (T2D) and is tightly linked to progressive β-cell dysfunction and loss. It is now well established that the "toxic oligo...
A single-nucleus multiomic study of preoptic area cells in prepubertal control vs prenatally androgenized female mice [0.03%]
prenatal暴露于雄激素的雌性青春期前小鼠视前区细胞的单核多组学分析
Laura L Burger,Rujuta M Chikodikar,Suzanne M Moenter
Laura L Burger
Polycystic ovary syndrome (PCOS) is a common endocrine disorder with developmental origins. While the etiology is unclear, current postulates include epigenetic programming. Cell-type-specific epigenetic changes by which prenatal androgen e...
The EDC mixture 'NeuroMix' Alters Neuroendocrine Physiology, Fatty Food Preference, and the Central Reward Transcriptome [0.03%]
EDC混合物“NeuroMix”可改变神经内分泌生理、脂肪食物偏好及中枢奖励转录组
Emily N Hilz,Nicholas R Gonzalez,Elena Morales-Grahl et al.
Emily N Hilz et al.
Obesity prevalence has risen dramatically in recent decades, coincident with increasing human exposures to endocrine-disrupting chemicals (EDCs). Many EDCs act as "obesogens" by promoting adipogenesis and disrupting metabolism; however, lit...
Hypoglycemic conditions enhance neonatal β-cell glucose responsiveness via AMPK/mTOR-increased KATP channel density [0.03%]
低血糖通过AMPK/mTOR增加KATP通道密度从而增强新生儿β细胞的葡萄糖反应性
Ekaterina Novichkova,Haiqiang Dou,Nimisha Gupta et al.
Ekaterina Novichkova et al.
At birth, blood glucose levels drop sharply before rising to normoglycemic adult levels. This is accompanied by functional maturation of pancreatic β-cells and the acquisition of glucose-responsive insulin secretion. Although transcription...
Role of KNDy neurons in the negative-feedback suppression of gonadotropin secretion in female rats [0.03%]
KNDy神经元在雌鼠负反馈抑制促性腺激素分泌中的作用
Ana C Campideli-Santana,Kaoma S C Silva,Roberta Araujo-Lopes et al.
Ana C Campideli-Santana et al.
The hypothalamic neurons that coexpress kisspeptin, neurokinin B, and dynorphin (KNDy) play a crucial role in the control of gonadotropin-releasing hormone (GnRH) pulsatile release and, thereby, in luteinizing hormone (LH) and follicle-stim...
Compartmentalization of DHCR7 links 7DHC metabolism to B-ring unsaturated steroid synthesis in the equine fetal gonad [0.03%]
DHCR7的功能区室化将马胎生性腺中的7DHC代谢与B环不饱和类固醇合成联系起来
Katarzyna Malin,Alan J Conley,Margo Verstraete et al.
Katarzyna Malin et al.
The endocrinology of equine pregnancy is unique, but many of its unusual phenomena closely resemble pregnancy in women. Placental estrone synthesis uses fetal adrenal androgen precursors in women, but from the fetal gonads in mares, peaking...
Adrenal rather than central dysfunction limits HPA axis recovery after chronic glucocorticoid treatment in male mice [0.03%]
在雄性小鼠中，肾上腺功能障碍比中枢功能障碍限制了慢性糖皮质激素治疗后的HPA轴恢复
Lindsey S Gaston,Brenna C Jorgensen,Hannah R Friedman et al.
Lindsey S Gaston et al.
Glucocorticoid-induced adrenal insufficiency (GIAI) can persist for months after discontinuation of chronic corticosteroid therapy, placing patients at risk for life-threatening adrenal crises. This prolonged suppression has been attributed...
Single-cell ATAC-seq Reveals OVOL2 as a Downstream Negative Regulator of PRL-Mediated Proliferation in β-cells [0.03%]
单细胞ATAC测序揭示PRL调控的β细胞增殖通路中的OVOL2的作用
Nelmari Ruiz-Otero,Jin-Yong Chung,Ronadip R Banerjee
Nelmari Ruiz-Otero
Maternal pancreatic β-cells undergo functional and structural changes to adapt to increased metabolic demands during pregnancy. Lactogen signaling via the prolactin receptor (PRLR) contributes to these adaptations by increasing β-cell mas...