Metabolic Plasticity and Enzalutamide Resistance: Emerging Roles of PGK1 in Prostate Cancer [0.03%]
代谢重组和恩杂鲁胺耐药：PGK1在前列腺癌中的作用初探
Min Zhang,Xiaoqi Liu
Min Zhang
Enzalutamide resistance remains a key challenge in the treatment of advanced prostate cancer (PCa), as clinical efficacy is frequently hindered by acquired resistance. While reactivation of AR signaling including AR splice variants, has bee...
FARP1 Mediates cMET-Driven Motility in Androgen-Independent Prostate Cancer Cells [0.03%]
FARP1介导cMET驱动的雄激素非依赖性前列腺癌细胞迁移能力
Paola Robayo,Marcelo G Kazanietz,Martin J Baker et al.
Paola Robayo et al.
Activation of Rac1, a member of the Rho family of small GTPases and a well-established downstream effector of receptor tyrosine kinases (RTKs), has been linked to prostate cancer progression and predicts poor progression in prostate cancer ...
Correction to: "Transgenic Mice Overexpressing Human Fibroblast Growth Factor 23 (R176Q) Delineate a Putative Role for Parathyroid Hormone in Renal Phosphate Wasting Disorders" [0.03%]
Correction to: “过表达人成纤维细胞生长因子23（R176Q）的小鼠界定了甲状旁腺激素在肾脏磷浪费紊乱中的潜在作用”
Published Erratum
Endocrinology. 2026 May 6;167(6):bqag058. DOI:10.1210/endocr/bqag058 2026
NR3C1 is required for normal somatotrope differentiation and Foxo1 expression in pituitary [0.03%]
NR3C1在垂体正常生长激素细胞分化和Foxo1表达中起关键作用
Pratyusa Das,Ridwanullah A Abubakar,Nooshin Mojahed et al.
Pratyusa Das et al.
Glucocorticoids are an important signal for the differentiation of many types of cells. Consistent with this, several studies have demonstrated that glucocorticoids promote the somatotrope differentiation program and functionality. Interest...
Acidic extracellular pH-induced PTH secretion in male mouse parathyroids is OGR1-dependent [0.03%]
OGR1依赖性甲状旁腺外分泌酸化诱导雄性小鼠PTH分泌
Yanmei Yang,Mengcun Chen,Mingshu Cui et al.
Yanmei Yang et al.
The role of extracellular acidity in regulating parathyroid hormone (PTH) secretion in cultured mouse parathyroid glands (PTGs) has not studied to date, largely due to the technical difficulty of isolating mouse PTGs. We hypothesized that a...
Perinatal Organophosphate Flame Retardant Exposure Alters Adult Stress Axis and Avoidance Behavior in Mice [0.03%]
孕期有机磷类阻燃剂暴露可改变小鼠成年后的应激轴和回避行为
Catherine M Rojas,Julia DeLucca,Caylee A Brown et al.
Catherine M Rojas et al.
Organophosphate flame retardants (OPFRs) are ubiquitous flame-retardant additives with endocrine-disrupting properties. Despite increasing evidence that OPFRs impact neurodevelopment, their effects on the neuroendocrine stress response rema...
Maxwell Ethan Edmonds
Maxwell Ethan Edmonds
Male infertility is increasing in prevalence due to cancer treatment, environmental exposures, and patient-specific syndromes. Traditional two-dimensional culture systems inadequately recapitulate the complex three-dimensional architecture,...
Breaking the bonds: targeting protein dimerization for prostate cancer therapy [0.03%]
突破限制：以前列腺癌治疗为目标作用于蛋白质二聚化
Nidhi Singh,Hannelore V Heemers
Nidhi Singh
Metastatic prostate cancer (PCa) remains a major cause of cancer deaths in western men. Although androgen deprivation therapy (ADT) initially induces remissions, patients ultimately develop uncurable castration resistance, underscoring the ...
Disease-associated mutations in the STAT5B SH2 domain reprogram hepatic cholesterol and lipid metabolism [0.03%]
STAT5B SH2结构域的疾病相关突变可重构肝脏胆固醇及脂质代谢路径
Hye Kyung Lee,Maxim Pyatkov,Oksana Gavrilova et al.
Hye Kyung Lee et al.
Growth hormone (GH) signaling through STAT5B is a central regulator of hepatic metabolism, yet the functional consequences of disease-associated STAT5B variants remain poorly understood. Here, we analyzed mice carrying STAT5BY665F (gain-of-...
Mineralocorticoid and glucocorticoid receptor cooperation drives advanced phenotypes in triple-negative breast cancer [0.03%]
盐皮质激素受体和糖皮质激素受体协同作用驱动三阴性乳腺癌的进展型表型
Sai Harshita Posani,Caroline H Diep,Raisa I Krutilina et al.
Sai Harshita Posani et al.
Oncogenic cell signaling, including the activation of cellular stress or cytokine-induced pathways, is a hallmark of cancer. In triple-negative breast cancer (TNBC), p38 MAPK phosphorylates glucocorticoid receptors (GR) at Ser134 in respons...