Longitudinal associations of epigenetic aging with cognitive aging in Hispanic/Latino adults from the Hispanic Community Health Study/Study of Latinos [0.03%]
美国Hispanic社区健康研究/拉丁裔研究中成年拉丁裔人的表观遗传衰老与认知衰老的纵向关联
Myriam Fornage,Wassim Tarraf,Rui Xia et al.
Myriam Fornage et al.
Due to the paucity of longitudinal DNA methylation data (DNAm), especially among Hispanic/Latino adults, the association between changes in epigenetic clocks over time and cognitive aging phenotypes has not been investigated. This longitudi...
Correction for: Posttranscriptional regulation of AKT by circular RNA angiomotin-like 1 mediates chemoresistance against paclitaxel in breast cancer cells [0.03%]
题注：环状RNA ANGML1通过调节Akt介导乳腺癌细胞对紫杉醇的耐药性
Jian Ma,Ling Fang,Qi Yang et al.
Jian Ma et al.
Published Erratum
Aging. 2025 Aug 31;17(8):2240. DOI:10.18632/aging.206315 2025
Lactobacillus amylovorus KU4 inhibits adipocyte senescence in aged mice through necdin regulation of p53 activity [0.03%]
乳酸菌通过调控p53活性抑制小鼠衰老脂肪细胞中的Necdin蛋白质
Garam Yang,Eunjeong Hong,Hyuno Kang et al.
Garam Yang et al.
Previously, we reported that Lactobacillus amylovorus KU4 (LKU4) ameliorates diet-induced metabolic disorders by regulating adipose tissue (AT) physiology. Since metabolic disorders and age-related pathological conditions mutually exacerbat...
Glycocalyx-targeted therapy prevents age-related muscle loss and declines in maximal exercise capacity [0.03%]
靶向糖萼防治与衰老相关的肌肉萎缩和最大运动能力下降
Daniel R Machin,Md Torikul Islam,Alec Malouf et al.
Daniel R Machin et al.
Age-related declines in cardiovascular function contribute to reduced physical capacity, both of which are independent predictors of mortality. We have previously demonstrated that glycocalyx-targeted therapy with Endocalyx™ that contains ...
Bleomycin promotes cellular senescence and activation of the cGAS-STING pathway without direct effect on fibrosis in an idiopathic pulmonary fibrosis model [0.03%]
博莱霉素促进细胞衰老和cGAS-STING通路的活化，而不是直接作用于特发性肺纤维化模型中的纤维化
Yoko Miura,Nadia Milad,Akiho Takata et al.
Yoko Miura et al.
Bleomycin is an effective anticancer agent that causes drug-induced interstitial pneumonia (IP). Medical history is a risk factor for adverse effects, particularly a history of IP and age-related fibrosis. Anti-cancer drugs for lung cancer ...
A protective role of SRC-1 against aging associated cognitive decline [0.03%]
SRC-1在抵抗衰老相关性认知衰退中起保护作用
Hesong Liu,Yongjie Yang,Jonathan C Bean et al.
Hesong Liu et al.
Introduction: Research indicates a strong correlation between obesity and the risk of dementia, both are linked to steroid receptor coactivator-1 (SRC-1), a transcriptional coactivator. ...
Analysis of the current state of frailty indexes and their implementation for aging intervention studies [0.03%]
虚弱指数的现状分析及其在衰老干预研究中的应用
Oliver G Frost,Anna Barkovskaya,Michael J Rae et al.
Oliver G Frost et al.
Animal lifespan studies are foundational to developing interventions against the biological aging process. In recent years, there has been rising interest in characterizing the effects of longevity therapeutics on health span. Frailty index...
Longitudinal relationship between social and CVD risk factors in older adults with prediabetes: the HRS 2006-2016 [0.03%]
横断面和纵向的心血管疾病危险因素与糖尿病前期老年人社会关系之间的关系：基于HRS2006-2016年数据的分析
Obinna Ekwunife,Yilin Xu,Raphael Fraser et al.
Obinna Ekwunife et al.
Background: This study examines how multiple social risk factors influence cardiovascular disease (CVD) risk control over time in older adults with prediabetes using a nationally representative cohort. ...
Deregulated miR-145 and miR-27b in hutchinson-gilford progeria syndrome: implications for adipogenesis [0.03%]
Hutchinson-Gilford早老症小鼠模型中miR-145和miR-27b的异常表达及其对脂肪细胞分化的影响研究
Felix Quirin Fenzl,Eva-Maria Lederer,Louisa Brumma et al.
Felix Quirin Fenzl et al.
Hutchinson-Gilford progeria syndrome (HGPS) is a rare and fatal disorder that causes premature aging, affecting approximately one in 4-8 million births. Most cases result from a mutation in the lamin A/C (LMNA) gene, leading to the producti...
Mitochondrial proteins as biomarkers of cellular senescence and age-associated diseases [0.03%]
线粒体蛋白与细胞衰老及年龄相关疾病标志物
Anna Panfilova,Tatiana Zubareva,Ekaterina Mironova et al.
Anna Panfilova et al.
Research in the field of mitochondrial biomarkers plays an important role in understanding the processes of cellular aging. Mitochondria are not only the energy centers of the cell, but also key regulators of signaling within the cell. They...