Role of apolipoprotein E (ApoE) ε4 in cognitive impairment after a stroke: a prospective cohort study [0.03%]
载脂蛋白ε4在脑卒中后认知障碍中的作用：前瞻性队列研究
Jia-Hung Chen,Lung Chan,Chien-Tai Hong et al.
Jia-Hung Chen et al.
Although apolipoprotein E (ApoE) ε4 is a well-established risk factor for Alzheimer disease, its role in the development of post-stroke cognitive impairment (PSCI) remains uncertain. In this prospective cohort study, we recruited patients ...
APOE genotype and biological age impact inter-omic associations related to bioenergetics [0.03%]
载脂蛋白E基因型和生物学年龄影响与生物能量相关的组学关联
Dylan Ellis,Kengo Watanabe,Tomasz Wilmanski et al.
Dylan Ellis et al.
Apolipoprotein E (APOE) modifies human aging; specifically, the ε2 and ε4 alleles are among the strongest genetic predictors of longevity and Alzheimer's disease (AD) risk, respectively. However, detailed mechanisms for their influence on...
Defining the hypoxic thresholds that trigger blood-brain barrier disruption: the effect of age [0.03%]
低氧引发血脑屏障破坏的阈值与年龄的影响：定义低氧引发血脑屏障破坏的阈值
Arjun Sapkota,Sebok K Halder,Richard Milner
Arjun Sapkota
Chronic mild hypoxia (CMH; 8% O2) triggers transient blood-brain barrier (BBB) disruption, an effect greatly increased with age. As BBB disruption predisposes to neuronal death and cognitive decline, here we defined the hypoxic thresholds t...
Oxytocin modulates insulin and GLP-1 secretion in pancreatic islets [0.03%]
催产素通过作用于胰岛调节胰岛素和GLP-1的分泌
Kasumi Hattori,Masaru Shimizu,Megumi Yamachi et al.
Kasumi Hattori et al.
Objective: Oxytocin (Oxt) is secreted to the peripheral body through the pituitary gland and can induce insulin secretion under high glucose conditions. Insulin secretion is regulated by various factors including glucagon...
Dietary associations with reduced epigenetic age: a secondary data analysis of the methylation diet and lifestyle study [0.03%]
与减缓表观遗传老化的饮食因素相关性：一项关于DNA甲基化与饮食生活方式研究的二次数据分析
Jamie L Villanueva,Alexandra Adorno Vita,Heather Zwickey et al.
Jamie L Villanueva et al.
Background: Aging is the primary risk factor for developing non-communicable chronic diseases, necessitating interventions targeting the aging process. Outcome measures of biological aging used in these interventions are ...
Impact of Factor Xa inhibitors on cardiovascular events in older patients with nonvalvular atrial fibrillation [0.03%]
Xa因子抑制药对老年非瓣膜性房颤患者心血管事件的影响
Masahiko Takahashi,Takeshi Morimoto,Ryu Tsushima et al.
Masahiko Takahashi et al.
Background: Experimental studies have reported that Factor Xa inhibitors (Xa-Is) have positive effects on cardiac muscles and blood vessels via protease-activated receptor 2 inhibition, suggesting the preventive effects o...
Frailty predicts adverse clinical outcomes in patients with moderate to severe chronic kidney disease [0.03%]
衰弱可预测中重度慢性肾脏病患者的不良临床结局
Chiung-Ying Huang,Hsiao-Mei Tsao,Shu-Ling Liang et al.
Chiung-Ying Huang et al.
Background and aim: Frailty predicts adverse clinical outcomes in older adults. Its prognoses in individuals with specific illnesses have not been fully explored. This study aimed to investigate the impact of frailty by u...
Pharmacological recapitulation of the lean phenotype induced by the lifespan-extending sulfur amino acid-restricted diet [0.03%]
药物模拟寿命延长的低硫氨基酸节食诱导的瘦素表型
Naidu B Ommi,Dwight A L Mattocks,Karel Kalecký et al.
Naidu B Ommi et al.
Sulfur amino acid restriction (SAAR), lowering the dietary concentration of sulfur amino acids methionine and cysteine, induces strong anti-obesity effects in rodents. Due to difficulties in formulating the SAAR diet for human consumption, ...
Retraction of: Apigenin inhibits growth and migration of fibroblasts by suppressing FAK signaling [0.03%]
撤稿：芸香素通过抑制FAK信号转导来抑制成纤维细胞的生长和迁移
Hongyi Wang,Bingyu Guo,Shixiu Lin et al.
Hongyi Wang et al.
Correction for: Maternal high sugar and fat diet benefits offspring brain function via targeting on the gut-brain axis [0.03%]
Correction: 高糖高脂饮食通过作用于肠-脑轴改善子代大脑功能
Dongdong Wang,Haiting Zhang,Miao Zeng et al.
Dongdong Wang et al.
Published Erratum
Aging. 2025 Mar 31;17(3):881-882. DOI:10.18632/aging.206229 2025