A decline in glycolytic ATP production is the fundamental mechanism limiting lifespan; species with an optimal rate of decline over time survived [0.03%]
糖酵解ATP生成速率的根本下降是寿命的限制机制；具有最佳速率下降水平的物种生存了下来
Akihiko Taguchi,Yuka Okinaka,Carsten Claussen et al.
Akihiko Taguchi et al.
Glycolytic ATP production declines with age, contributing to common aging phenotypes such as reduced cell division and impaired DNA & mitochondria repair. Notably, immortal cells exhibit a metabolic profile characterized by sustained, highl...
Single-cell transcriptomics reveal intrinsic and systemic T cell aging in COVID-19 and HIV [0.03%]
单细胞转录组揭示了COVID-19和HIV中T细胞衰老的内在机制和系统问题
Alan Tomusiak,Sierra Lore,Morten Scheibye-Knudsen et al.
Alan Tomusiak et al.
Biomarkers of aging offer insights into how diseases and interventions affect biological systems. However, most current biomarkers are based on bulk cell measurements, making it difficult to distinguish between changes driven by shifts in c...
Polyploidy-induced senescence: Linking development, differentiation, repair, and (possibly) cancer? [0.03%]
多倍体诱导的衰老：连接发育、分化、修复（以及可能的癌症）？
Iman M Al-Naggar,George A Kuchel
Iman M Al-Naggar
Causal effects of inflammation on long-term mortality: A mendelian randomization study [0.03%]
利用孟德尔随机化研究炎症对长期死亡率的因果效应
Eliano P Navarese,Dean J Kereiakes,Timothy D Henry et al.
Eliano P Navarese et al.
Background: Interleukin-6 (IL6) signaling plays a key role in inflammation and cardiovascular disease, but its causal effect on long-term mortality remains unclear. We aimed to assess whether genetically proxied levels of...
Hyejin Mun,Do-Won Ham,Nam Chul Kim et al.
Hyejin Mun et al.
During mammalian aging, there are changes in abundance of noncoding RNAs including microRNAs, long noncoding RNAs, and circular RNAs. Although global profiles of the human transcriptome and epitranscriptome during the aging process are avai...
David Gems,Alexander Carver,Yuan Zhao
David Gems
Aging (senescence) is characterized by development of diverse senescent pathologies and diseases, leading eventually to death. The major diseases of aging, including cardiovascular disease, cancer and chronic obstructive pulmonary disease (...
Retraction of: Esophageal carcinoma cell-excreted exosomal uc.189 promotes lymphatic metastasis [0.03%]
撤回：食管癌细胞分泌的外泌体uc.189促进淋巴转移
Zhiyan Ding,Yun Yan,Yu Lian Guo et al.
Zhiyan Ding et al.
Correction for: Combined identification of ARID1A, CSMD1, and SENP3 as effective prognostic biomarkers for hepatocellular carcinoma [0.03%]
题注：联合鉴定ARID1A、CSMD1和SENP3作为肝细胞癌有效预后生物标志物的识别
Yuanyuan Zhao,Bo Yang,Dong Chen et al.
Yuanyuan Zhao et al.
Published Erratum
Aging. 2025 Dec 31;17(12):3003-3004. DOI:10.18632/aging.206350 2025
Age-specific DNA methylation alterations in sperm at imprint control regions may contribute to the risk of autism spectrum disorder in offspring [0.03%]
精子中印记控制区域年龄特异性DNA甲基化改变可能会影响子代自闭症谱系障碍的风险
Eugenia Casella,Jana Depovere,Chantal Delger et al.
Eugenia Casella et al.
Research findings suggest that advanced paternal age is associated with an increased risk of autism spectrum disorder (ASD) in children. The biological process behind this father-to-child inheritance of a disease may be driven by sperm epig...
A combination of differential expression and network connectivity analyses identifies a common set of RNA splicing and processing genes altered with age across human tissues [0.03%]
差异表达和网络连接分析的结合鉴定出人类组织中共同的一组RNA剪接和加工基因随着年龄的变化而变化
Caio M P F Batalha,André Fujita,Nadja C de Souza-Pinto
Caio M P F Batalha
Although transcriptomic changes are known to occur with age, the extent to which these are conserved across tissues is unclear. Previous studies have identified little conservation in age-modulated genes in different tissues. Here, we sough...