Investigating POLG-driven modulation of cancer stemness: a pilot study in breast cancer cells [0.03%]
POLG驱动的癌症干细胞特性调控研究——乳腺癌细胞系初步探索
Chiara Chinigò,Conor J Sugden,Marco Fiorillo et al.
Chiara Chinigò et al.
Mitochondria have emerged as key regulators of breast cancer stem cell (CSC) biology. Mitochondrial metabolic pathways, including oxidative phosphorylation (OXPHOS) and mitochondrial biogenesis, are frequently altered during tumorigenesis, ...
David Gems,Marco Demaria
David Gems
Transcriptomic aging clock analysis identifies key genes in opioid dependence [0.03%]
转录组衰老钟分析发现阿片类物质依赖的关键基因
Hai Duc Nguyen,Mary Peace McRae,Sangkyu Kim et al.
Hai Duc Nguyen et al.
Opioid dependence is a complex disorder influenced by multiple factors, including aging and genetic factors. However, the underlying molecular mechanisms remain incompletely understood. This in silico study integrated transcriptomic profili...
A brief history of the hyperfunction theory of aging and future directions [0.03%]
衰老的超功能理论简史及未来方向预测
João Pedro de Magalhães
João Pedro de Magalhães
Aging remains a mystery of biology, and debate regarding why we age has been ongoing for centuries. Many theories of aging have been proposed, most of which focus on errors and the gradual accumulation of molecular damage. By contrast, agin...
Adipo-neuroinflammation, cognitive impairment and surrogate markers of cardiovascular risk in patients with Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) [0.03%]
与代谢功能障碍相关脂肪肝病(MASLD)患者中的脂毒性-神经炎症、认知障碍及心血管风险替代标志物水平
Gaetano Pacinella,Alessandro Del Cuore,Maria Grazia Basso et al.
Gaetano Pacinella et al.
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly recognised as a systemic condition associated with cardiometabolic and neurovascular alterations. Lipocalin-2 (LCN2), a marker o...
Selective targeting of cancer and senescence via shared metabolic shifts extends lifespan of old mice [0.03%]
通过共享代谢变化选择性地靶向癌症和衰老可延长老年小鼠的寿命
Zachery R Robinson,Sabrina C Fong,Daniella Y Choi et al.
Zachery R Robinson et al.
Eliminating both senescent and cancer cells through pharmacological intervention presents a powerful therapeutic strategy against aging and tumor progression. Navitoclax has emerged as a promising candidate with both senolytic and antitumor...
Towards integration of healthspan strategies into the Italian National Health Service [0.03%]
迈向在意大利国家健康服务体系中整合健康期策略
Nicola Marino,Matteo Fiore,Aureliano Stingi et al.
Nicola Marino et al.
Italy currently ranks among the world's oldest nations, with adults aged ≥65 years accounting for 24.1% of the population - the highest proportion in the EU - and a projected median age of 51 years by 2050. While life expectancy at birth r...
Correction for: miR-21 upregulation exacerbates pressure overload-induced cardiac hypertrophy in aged hearts [0.03%]
miR-21上调可加剧老年心脏压力超负荷诱导的心肌肥厚纠正：miR-21上调可加剧老年心脏压力超负荷诱导的心肌肥厚
Wei-Ting Chang,Jhih-Yuan Shih,Yu-Wen Lin et al.
Wei-Ting Chang et al.
Published Erratum
Aging. 2026 Jul 8;18(1):813-814. DOI:10.18632/aging.206404 2026
Ana Beathriz Leite Lorente,Sergio Vazquez,Kanako Iwasaki et al.
Ana Beathriz Leite Lorente et al.
Senescent pancreatic beta (β)-cells accumulate with age and contribute to impaired insulin secretion and progression of type 2 diabetes mellitus (T2DM). Although the urokinase-type plasminogen activator receptor (uPAR; encoded by PLAUR) ha...
Inhibition of peroxisomal protein PRX-11 promotes longevity in Caenorhabditis elegans via enhancements to mitochondria [0.03%]
抑制过氧化物酶体蛋白PRX-11可增强线粒体功能促进秀丽隐杆线虫寿命延长
Yash Flora,Dhriti Shastri,Kathryn R DeLeo et al.
Yash Flora et al.
Peroxisomes execute essential functions in cells, including detoxification and lipid oxidation. Despite their centrality to cell biology, the relevance of peroxisomes to aging remains understudied. We recently reported that peroxisomes are ...