Identification of key genes with differential correlations in prostate cancer [0.03%]
识别前列腺癌中差异相关的关键基因
Zepai Chi,Yuanfeng Zhang,Xuwei Hong et al.
Zepai Chi et al.
Background: Prostate cancer, a major global health issue for men, remains a critical clinical challenge in treatment, highlighting the need for improved biomarkers. Treatment options for prostate cancer include active sur...
Retraction of: Long non-coding RNA NNT-AS1 promotes cholangiocarcinoma cells proliferation and epithelial-to-mesenchymal transition through down-regulating miR-203 [0.03%]
撤稿：长链非编码RNA NNT-AS1通过下调miR-203促进胆管癌细胞增殖及上皮间质转化
Yulei Gu,Zhiqiang Zhu,Hui Pei et al.
Yulei Gu et al.
Correction for: The regulation of p53 by phosphorylation: a model for how distinct signals Integrate into the p53 pathway [0.03%]
关于p53磷酸化的调控：一个关于不同信号如何整合进p53通路的模型的更正注释
Nicola J Maclaine,Ted R Hupp
Nicola J Maclaine
Published Erratum
Aging. 2025 Sep 30;17(9):2449. DOI:10.18632/aging.206321 2025
The role of phenylalanine and tyrosine in longevity: a cohort and Mendelian randomization study [0.03%]
一项队列研究和孟德尔随机化研究显示苯丙氨酸和酪氨酸在长寿中的作用
Jie V Zhao,Yitang Sun,Junmeng Zhang et al.
Jie V Zhao et al.
Background: Protein restriction increases lifespan, however, the specific amino acids affecting lifespan are unclear. Tyrosine and its precursor, phenylalanine, may influence lifespan through their response to low-protein...
Parminder Singh,Anil Gautam,Marissa N Trujillo et al.
Parminder Singh et al.
Growth hormone (GH) plays a crucial role in various physiological functions, with its secretion tightly regulated by complex endocrine mechanisms. Pathological conditions such as acromegaly or pituitary tumors result in elevated circulating...
L-β-aminoisobutyric acid (L-BAIBA) in combination with voluntary wheel running exercise enhances musculoskeletal properties in middle-age male mice [0.03%]
L-β-氨基异丁酸(L-BAIBA)与自由车轮运动锻炼结合增强中年小鼠的肌肉骨骼特性
Julian A Vallejo,Yukiko Kitase,Thiagarajan Ganesh et al.
Julian A Vallejo et al.
Contracting skeletal muscles secrete the metabolite L-β-aminoisobutyric acid (L-BAIBA), which when supplemented in the diet can mitigate disuse-induced musculoskeletal dysfunction. However, the effects of L-BAIBA supplementation alone and ...
Depletion of the TRF1 telomere-binding protein leads to leaner mice with altered metabolic profiles [0.03%]
端粒结合蛋白TRF1的损耗导致小鼠体重变轻且代谢轮廓改变
Jessica Louzame Ruano,Leire Bejarano,Rosa Serrano et al.
Jessica Louzame Ruano et al.
TRF1, a component of the telomere shelterin complex, plays crucial roles in telomere protection, telomere length regulation, and stemness. Here, we describe a previously unknown connection between TRF1 and metabolism. Telomere attrition has...
Infusion of blood from young and old mice modulates amyloid pathology [0.03%]
来自年轻和老年小鼠的血液对淀粉样蛋白病理具有调节作用
Matias Pizarro,Ruben Gomez-Gutierrez,Ariel Caviedes et al.
Matias Pizarro et al.
Alzheimer's disease (AD) is a neurodegenerative disease characterized by the accumulation of misfolded proteins in the brain. Recently, the impact of blood components in the progression of this disease has come to attention. This study inve...
Roles of plasminogen activator inhibitor-1 in aging-related muscle and bone loss in mice [0.03%]
纤溶酶原激活物抑制剂-1在小鼠与衰老相关的肌肉和骨质流失中的作用
Takashi Ohira,Naoyuki Kawao,Yuya Mizukami et al.
Takashi Ohira et al.
Aging-related sarcopenia and osteoporosis are musculoskeletal disorders characterized by accelerated muscle and bone loss. Plasminogen activator inhibitor-1 (PAI-1), a fibrinolysis inhibitor, is involved in various pathological conditions, ...
Runx1 overexpression induces early onset of intervertebral disc degeneration [0.03%]
RUNX1过度表达诱导椎间盘早期退变
Takanori Fukunaga,Martha Elena Diaz-Hernandez,John G Heller et al.
Takanori Fukunaga et al.
Intervertebral disc degeneration (IDD) is closely associated with aging. Although the Runt-related transcription factor 1 (RUNX1) is well known for its role in skeletal development and other musculoskeletal related diseases such as osteoart...