Retraction of: MiR-519d targets HER3 and can be used as a potential serum biomarker for non-small cell lung cancer [0.03%]
撤回：MiR-519d 目标是HER3 并且可以用于非小细胞肺癌的潜在血清生物标志物
Aili Wang,Hongxia Zhang,Jinxiang Wang et al.
Aili Wang et al.
Epigenetic age and accelerated aging phenotypes: a tumor biomarker for predicting colorectal cancer [0.03%]
表观遗传年龄和加速衰老表型：预测结直肠癌的肿瘤生物标志物
Su Yon Jung,Matteo Pellegrini,Xianglong Tan et al.
Su Yon Jung et al.
Background: Epigenetic clocks, estimated via DNA methylation (DNAm), reflect individuals' biological aging in multiple tissues and are associated with age-related diseases, but their functional role in colorectal cancer (...
Takuji Kawamura,Mitsuru Higuchi,Zsolt Radak et al.
Takuji Kawamura et al.
Emerging evidence suggests that physical activity, exercise, and physical fitness may delay or reverse epigenetic aging, with implications for the extension of healthspan. This Perspective review defines essential exercise-related terminolo...
Frailty associates with respiratory exacerbations and mortality in the COPDGene cohort [0.03%]
衰弱与COPDGene队列急性加重和死亡率相关性研究
Eleanor Kate Phillips,Yichen Huang,Elizabeth Regan et al.
Eleanor Kate Phillips et al.
Frailty is associated with respiratory exacerbations and mortality in individuals with Chronic Obstructive Pulmonary Disease (COPD). Among those with a smoking history and normal spirometry, frailty's association with respiratory outcomes i...
Enhancing oocyte activation in women with ovarian failure: clinical outcomes of the Stem Cell Regenera study using G-CSF mobilization of peripheral blood stem cells and intraovarian injection of stem cell factor-enriched platelet rich plasma in real-world-practice [0.03%]
干细胞再生研究：使用G-CSF动员外周血干细胞和富集血小板的血小板丰富血浆卵巢内注射，改善卵巢衰竭女性卵母细胞活化的临床结局
Amparo Santamaria,Ana Ballester,Manuel Muñoz
Amparo Santamaria
The study assesses the effectiveness and safety of the Stem Cell Regenera Treatment for oocyte activation in women with ovarian failure, including conditions such as Poor Ovarian Response (POR), Diminished Ovarian Reserve (DOR), and Prematu...
Implications of the KHDC4-TRAF2 axis in the context of prostate cancer prognosis [0.03%]
KHDC4-TRAF2轴在前列腺癌预后中的意义
Su-Wei Hu,Chia-Chang Wu,Shao-Wei Dong et al.
Su-Wei Hu et al.
The inability to effectively identify the formation of advanced-stage tumors poses a challenge in precisely determining when to intervene in prostate cancer (PCa). Despite the use of PSA as a screening factor, it still falls short in signif...
rDNA copy number variation and methylation from birth to sexual maturity [0.03%]
从出生到性成熟期间的rDNA拷贝数变化及甲基化情况
Alina Michler,Sarah Kießling,Jana Durackova et al.
Alina Michler et al.
Ribosomal DNA transcription is essential for ribosome biogenesis and the production of proteins. Using a combination of droplet digital PCR and deep bisulfite sequencing, we have quantified both the absolute number as well as the methylatio...
Development of a novel transcriptomic measure of aging: Transcriptomic Mortality-risk Age (TraMA) [0.03%]
新型转录组测龄方法的开发：转录风险年龄(TraMA)
Eric T Klopack,Gokul Seshadri,Thalida Em Arpawong et al.
Eric T Klopack et al.
Increasingly, research suggests that aging is a coordinated multi-system decline in functioning that occurs at multiple biological levels. We developed and validated a transcriptomic (RNA-based) aging measure we call Transcriptomic Mortalit...
Developing a quantitative estimate of muscle age acceleration by a novel phenotypic clock: cross-sectional study in healthy, middle-aged and older adults [0.03%]
开发定量估算肌肉衰老加速的表型钟并在健康中老年人群中的横断面研究
Lucia Ventura,Antonella Cano,Marco Morrone et al.
Lucia Ventura et al.
Sarcopenia is a progressive disease characterized by reductions in muscle mass strength and physical performance. Among the initiatives launched to increase awareness, the European Working Group on Sarcopenia in Older People (EWGSOP) is con...
Dynamic and reversible transcriptomic age shifts induced by COVID-19 in Korean whole blood [0.03%]
新冠肺炎引起的韩国全血 transcriptomic 年龄的动态及可逆变化
Kyungwhan An,Yoonsung Kwon,Jihun Bhak et al.
Kyungwhan An et al.
We developed the first genome-wide transcriptomic clock specific to Korean ethnicity to predict chronological age using whole blood samples from 440 healthy individuals. Our analysis revealed profound age acceleration - up to 21.31 years - ...