Romain Menard,Romain Madelaine
Romain Menard
Sarcopenia, affecting over 60% of individuals above age 80, represents a critical challenge for aging populations worldwide. Despite formal recognition as a disease by the WHO in 2016, therapeutic approaches remain limited to exercise and n...
Hilah Gal,Valery Krizhanovsky
Hilah Gal
Cellular senescence is a stable form of cell-cycle arrest induced by diverse intrinsic and extrinsic stimuli. While senescence contributes to tumor suppression, wound repair, and placental and embryonic development, the chronic accumulation...
Life expectancy and causes of death in classical laminopathic progeroid syndromes: systematic review with individual-patient data synthesis [0.03%]
经典核纤层蛋白病早衰综合征的预期寿命及死亡原因：个体患者数据分析的系统综述
Carlos López-Vila,Manuel García-Cordeiro,Luís Estévez-Martínez et al.
Carlos López-Vila et al.
Classical laminopathic progeroid syndromes link nuclear-envelope defects to accelerated aging, but the specific prognosis for each subtype remains unclear. We conducted a PRISMA-guided systematic review and individual-patient data (IPD) syn...
Age-related dysfunctions of the neuroendocrine axes in nonhuman primates with depression-like and anxious behavior [0.03%]
非人灵长类抑郁和焦虑行为相关的神经内分泌轴老化异常
Nadezhda D Goncharova
Nadezhda D Goncharova
With age, the incidence of stress-related pathologies, in the etiopathogenesis of which endocrine dysfunctions play an important role, increases. This review presents data on the study of age-related features in functioning of the key adapt...
Angelos Papaspyropoulos,Giorgos Theocharous,Orestis A Ntintas et al.
Angelos Papaspyropoulos et al.
Cellular senescence and stemness represent two biological entities with several opposing properties. However, both senescence and stemness serve to maintain tissue homeostasis, via different mechanisms. In adults, while non-dividing senesce...
Early-life determinants of cardiometabolic outcomes and accelerated biological ageing in Colombia [0.03%]
哥伦比亚儿童心血管代谢结局和生物衰老的早期生命决定因素
Juan Carlos Rivillas,Emilie Courtin,Eleanor Winpenny et al.
Juan Carlos Rivillas et al.
Background: Adverse childhood experiences (ACEs) are critical early-life determinants of long-term health, yet their association with biological ageing and cardiometabolic risk remains poorly understood. We examined the a...
Systemic cancer risk profile in neovascular age-related macular degeneration: insights into shared aging-related mechanisms from a nationwide population-based study [0.03%]
来自全国基于人群的队列研究的新血管年龄相关性黄斑变性系统癌症风险谱系：关于共享衰老机制的见解
Hyeong Min Kim,Yoonjong Bae,Mina Kim et al.
Hyeong Min Kim et al.
Neovascular age-related macular degeneration (nAMD) is a leading cause of vision loss in older adults and is increasingly recognized as a manifestation of systemic aging involving vascular and inflammatory pathways. Emerging evidence sugges...
Transcriptional programs diverge in aging mouse and human skeletal muscle [0.03%]
小鼠和人类骨骼肌衰老的转录程序有所不同
Charles D Hwang,Siti Rahmayanti,Yori Endo et al.
Charles D Hwang et al.
Animal models provide a crucial scientific substrate for medical innovation, yet findings in these models do not always translate directly to humans. Although murine models are extensively employed to study skeletal muscle aging, the extent...
Public health in the age of longevity interventions: from prevention to system-wide resilience [0.03%]
长寿干预时代的公共卫生：从预防到系统抗逆性
Jochen Mierau,Marco Demaria
Jochen Mierau
Blue period - features of senescence 30 years after beta-galactosidase [0.03%]
蓝色时期-β半乳糖苷酶后的30年衰老的特征
Chisaka Kuehnemann,Christopher D Wiley
Chisaka Kuehnemann
Cellular senescence is a multi-phenotypic stress or damage response characterized by a stable cell cycle arrest and the secretion of a myriad of biologically active molecules, commonly known as the senescence-associated secretory phenotype ...