Specific knockout of notch-1 attenuates non-alcoholic fatty liver disease by promoting SHP2 phosphorylation [0.03%]
NOTCH-1特异性敲除通过促进SHP2磷酸化来缓解非酒精性脂肪肝病
Qian Gao,Yonggang Lu,Weiling Zhou
Qian Gao
Objective: To investigate the effect of Notch-1 signaling on NAFLD and its molecular mechanism. Methods: The lipid deposition in liver ...
Obesity, birth weight, and lifestyle factors for frailty: a Mendelian randomization study [0.03%]
遗传概率化研究肥胖、体重和生活方式因素对脆弱的影响
Yingzhen Gu,Zuozhi Li,Aimin Dang et al.
Yingzhen Gu et al.
Obesity, birth weight and lifestyle factors have been found associated with the risk of frailty in observational studies, but whether these associations are causal is uncertain. We conducted a two-sample Mendelian randomization study to inv...
Machine learning algorithm integrates bulk and single-cell transcriptome sequencing to reveal immune-related personalized therapy prediction features for pancreatic cancer [0.03%]
机器学习算法整合批量和单细胞转录组测序数据以揭示针对胰腺癌的免疫相关个性化治疗预测特征
Longjun Zang,Baoming Zhang,Yanling Zhou et al.
Longjun Zang et al.
Pancreatic cancer (PC) is a digestive malignancy with worse overall survival. Tumor immune environment (TIME) alters the progression and proliferation of various solid tumors. Hence, we aimed to detect the TIME-related classifier to facilit...
MiR-203a-3p attenuates apoptosis and pyroptosis of chondrocytes by regulating the MYD88/NF-κB pathway to alleviate osteoarthritis progression [0.03%]
miR-203a-3p通过调节MYD88/NF-κB通路抑制软骨细胞凋亡和焦亡以缓解骨关节炎进展
Jiayi Chen,Zhutong Liu,He Sun et al.
Jiayi Chen et al.
Background: Osteoarthritis (OA) is a degenerative joint disease that imposes a significant socioeconomic burden worldwide. Our previous studies revealed a down-regulation of miR-203a-3p in the knee tissues of OA patients....
Boyi Jiang,Jiapeng Yang,Rui He et al.
Boyi Jiang et al.
Background: Xuanwei lung cancer (XWLC) is well-known for its high incidence and mortality. However, the molecular mechanism is still unclear. Methods: ...
Single-cell dissection reveals the role of aggrephagy patterns in tumor microenvironment components aiding predicting prognosis and immunotherapy on lung adenocarcinoma [0.03%]
单细胞解析揭示聚集自噬模式在肺癌肿瘤微环境成分中助于预测预后和免疫治疗的作用
Xinti Sun,Fei Meng,Minyu Nong et al.
Xinti Sun et al.
Background: Lung adenocarcinoma (LUAD) is one of the leading malignant cancers. Aggrephagy plays a critical role in key genetic events for various cancers; yet, how aggrephagy functions within the tumor microenvironment (...
The effect of nutritional biochemical indexes on the hospitalization outcome of COVID-19 [0.03%]
营养生化指标对COVID-19住院结局的影响分析
Peng Wang,Wenying Shi,Xiaodi Zhao et al.
Peng Wang et al.
Aims to investigate the relationship between nutritional biochemical indexes and hospitalization outcomes of COVID-19 patients, 132 continuous patients with COVID-19 from December 2022 to January 2023 in Lishui hospital were retrospectively...
Gypenoside IX restores Akt/GSK-3β pathway and alleviates Alzheimer's disease-like neuropathology and cognitive deficits [0.03%]
甘草酸IX恢复Akt / GSK-3β途径并缓解类似阿尔茨海默病的神经病理学和认知缺陷
Ling Lei,Yong Luo,Dongkun Kang et al.
Ling Lei et al.
The main pathological changes of Alzheimer's disease (AD), a progressive neurodegenerative disorder, include senile plaque (deposited by amyloid beta), neurofibrillary tangle (formed by paired helical filaments composed of hyperphosphorylat...
Benidipine calcium channel blocker promotes the death of cigarette smoke-induced senescent cells and improves lung emphysema [0.03%]
苯地平钙通道阻滞剂可促进香烟烟雾诱导衰老细胞的清除并改善肺气肿病情
Alberta Palazzo,Gabriela Makulyte,Delphine Goerhig et al.
Alberta Palazzo et al.
Smoking is the main risk factor for many lung diseases including chronic obstructive pulmonary disease. Cigarette smoke (CS) contains carcinogenic and reactive oxygen species that favor DNA mutations and perturb the homeostasis and environm...
Angelica gigas extract inhibits acetylation of eNOS via IRE1α sulfonation/RIDD-SIRT1-mediated posttranslational modification in vascular dysfunction [0.03%]
Angelica gigas提取物通过IRE1α硫酸化/RIDD-SIRT1介导的翻译后修饰抑制血管功能障碍中的eNOS乙酰化
Geum-Hwa Lee,Hwa-Young Lee,Young-Je Lim et al.
Geum-Hwa Lee et al.
Angelica gigas NAKAI (AG) is a popular traditional medicinal herb widely used to treat dyslipidemia owing to its antioxidant activity. Vascular disease is intimately linked to obesity-induced metabolic syndrome, and AG extract (AGE) shows b...