Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results [0.03%]
雷帕霉素对安全和健康跨度指标一年后的的影响：PEARL实验结果
Mauricio Moel,Girish Harinath,Virginia Lee et al.
Mauricio Moel et al.
Design: This 48-week decentralized, double-blinded, randomized, placebo-controlled trial (NCT04488601) evaluated the long-term safety of intermittent low-dose rapamycin in a healthy, normative-aging human cohort. Particip...
Decreased mitochondrial NAD+ in WRN deficient cells links to dysfunctional proliferation [0.03%]
遗传性前列腺癌综合征关键基因WRN缺陷导致细胞内线粒体烟酰胺腺嘌呤二核苷酸消耗及其促瘤作用
Sofie Lautrup,Shi-Qi Zhang,Shinichiro Funayama et al.
Sofie Lautrup et al.
Werner syndrome (WS), caused by mutations in the RecQ helicase WERNER (WRN) gene, is a classical accelerated aging disease with patients suffering from several metabolic dysfunctions without a cure. While, as we previously reported, deplete...
Fisetin ameliorates vascular smooth muscle cell calcification via DUSP1-dependent p38 MAPK inhibition [0.03%]
fisetin通过Dusp1依赖性地抑制p38 Mapk来改善血管平滑肌细胞钙化
Mehdi Razazian,Sheyda Bahiraii,Azmat Sohail et al.
Mehdi Razazian et al.
Medial vascular calcification is highly prevalent in advanced age and chronic kidney disease (CKD), where it is associated with increased risk for cardiovascular events and mortality. Vascular smooth muscle cells (VSMCs) actively regulate t...
Comprehensive genomic characterization of programmed cell death-related genes to predict drug resistance and prognosis for patients with multiple myeloma [0.03%]
全面的基因组特征分析程序性细胞死亡相关基因以预测多发性骨髓瘤患者的药物耐受性和预后情况
Yan Li,Fuxu Wang,Hongbo Zhao et al.
Yan Li et al.
Background: Multiple myeloma (MM) is a cancer that is difficult to be diagnosed and treated. This study aimed to identify programmed cell death (PCD)-related molecular subtypes of MM and to assess their impact on patients...
Examining frailty phenotypes of community-dwelling older adults in Taiwan using the falls risk for older people in the community - Taiwan version (Tw-FROP-Com) [0.03%]
使用社区老年人跌倒风险评估量表-台湾版（Tw-FROP-Com）对我国社区老年人衰弱表型的研究
Ya-Mei Tzeng,Senyeong Kao,Wun-Sin Chen et al.
Ya-Mei Tzeng et al.
Background: Falls are the second leading cause of accidental injury-related deaths among Taiwanese adults aged 65 and older. This study examined the association between Fried frailty phenotypes and fall risk in this popul...
Mesenchymal stem cell-specific Sirt1 overexpression prevents sarcopenia induced by 1,25-dihydroxyvitamin D deficiency [0.03%]
缺1,25-二羟基维生素D诱导的间充质干细胞特异性Sirt1过表达可防止骨骼肌减少症发生发展
Haiyun Chen,Biqi Ren,Jing Wang et al.
Haiyun Chen et al.
Sarcopenia, characterized by an age-related decline in skeletal muscle mass and function, is closely linked to vitamin D deficiency. This study examines the role of Sirtuin 1 (Sirt1) and its regulation by vitamin D in preventing sarcopenia....
Accelerated aging associated with cancer characteristics and treatments among breast cancer survivors [0.03%]
与乳腺癌幸存者癌症特征和治疗相关的加速老化现象
Cong Wang,Jill B De Vis,Kirsten Nguyen et al.
Cong Wang et al.
Breast cancer (BC) survivors may experience accelerated aging due to detrimental effects of BC and/or its treatments. Our study aims to evaluate Phenotypic Age Acceleration (PAA), a biological age measure, among BC patients and assess its a...
Differential senolytic inhibition of normal versus Aβ-associated cholinesterases: implications in aging and Alzheimer's disease [0.03%]
正常与Aβ相关胆碱酯酶不同的senolytic抑制作用：在衰老和阿尔茨海默病中的意义
Sultan Darvesh,Meghan K Cash,Katrina Forrestall et al.
Sultan Darvesh et al.
Cellular senescence is a hallmark of aging and the age-related condition, Alzheimer's disease (AD). How senescence contributes to cholinergic and neuropathologic changes in AD remains uncertain. Furthermore, little is known about the relati...
The rodent aging interventions database (RAID): a data visualization tool for all studies reporting rodent lifespan extension [0.03%]
啮齿动物衰老干预数据库（RAID）：用于显示所有报道的寿命延长研究的数据可视化工具
Maximus V Peto,Anthony J Floyd,Ben Zealley et al.
Maximus V Peto et al.
Numerous studies have investigated the effects of various interventions on the lifespans of mice and rats. The design of future rodent lifespan extension experiments might consider experimental parameters used in earlier investigations, but...
Decreased surface receptors, function, and suboptimal osteoclasts-induced cell expansion in natural killer (NK) cells of elderly subjects [0.03%]
老年人自然杀伤细胞中表面受体减少，功能减退及破骨细胞诱导的细胞增殖下降(NK)细胞
Kawaljit Kaur,Anahid Jewett
Kawaljit Kaur
Natural killer (NK) cells are known for their cytotoxic and cytokine secretion capabilities. The balance of activating and inhibitory receptors on their surface regulates NK cell function and survival. However, it is not fully understood ho...