Complementary insights from wastewater surveillance and the toxicology findings of clinical presentations involving new psychoactive substances in Australia [0.03%]
澳大利亚污水监测和临床表现涉及新型精神活性物质的毒理学结果的互补见解
Richard Bade,Dhayaalini Nadarajan,Keith Harris et al.
Richard Bade et al.
The growing emergence of new psychoactive substances (NPS) challenges traditional approaches to drug monitoring, highlighting a need for innovative surveillance strategies. We explored the potential to better understand the NPS market in Au...
Development and Validation of an LC-MS/MS Method for the Determination of Glucocorticoids and Endocannabinoids in Hair: Application to Longitudinal Pregnancy Samples [0.03%]
毛发中糖皮质激素和内源大麻素的LC-MS/MS测定法的开发与验证：在纵向妊娠样本中的应用
Brooke Fontaine,Alexis Palma,Marta Concheiro
Brooke Fontaine
Chronic stress has been associated with adverse health outcomes, including anxiety, depression, and cardiovascular disease. During pregnancy, stress-related biological changes may affect maternal and fetal health; however, assessing cumulat...
Toxicokinetics and Tissue Distribution of Carbofuran and Its Six Metabolites in Rats [0.03%]
毒死蜱及其六种代谢产物在大鼠体内的毒代动力学和组织分布研究
Xian Ju,Di Liang,Xiaoyuan Yang et al.
Xian Ju et al.
To our knowledge, this study provides the first integrated liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based characterization of the toxicokinetics, excretion, and multi-tissue distribution of carbofuran and six major metaboli...
Occipital Lobe to Femoral Blood Ratios of Amphetamine, Methamphetamine, Cocaine, Benzoylecgonine, Cocaethylene, and Fentanyl in Postmortem Cases [0.03%]
尸检案件中安非他明、甲基苯丙胺、可卡因、苯环己酮和芬太尼的枕叶与股骨血比值分布
Grayce Behnke,Teresa R Gray
Grayce Behnke
Interpretation of postmortem toxicology results is complicated by postmortem redistribution (PMR), which can alter drug concentrations between tissues and blood (BL). This study evaluates brain (BR) to BL concentration ratios for amphetamin...
Tramadol in drug-facilitated sexual assault: Global case prevalence, pharmacology and drug interactions [0.03%]
药物助淫性侵犯中的曲马多：全球案例普遍性、药理学和药物相互作用
David Stewart-Yates,Garth L Maker,John Coumbaros
David Stewart-Yates
Drug-facilitated sexual assault (DFSA) refers to sexual acts where the victim is incapacitated by the effects of psychotropic substances, causing impaired ability to prevent an attack and/ or provide informed consent. To date, the level of ...
From Blood to Brain: Postmortem Brain Concentrations and Brain-Blood Ratios of Chlorprothixene, Clozapine, Olanzapine and Quetiapine [0.03%]
从血液到大脑：氯丙噻吨、氯氮平、奥氮平和喹硫平的死后脑浓度及血脑比值分析
Mikayla Zoë van der Meer,Brian Schou Rasmussen,Michael Nedahl et al.
Mikayla Zoë van der Meer et al.
Treatment with antipsychotics such as chlorprothixene, clozapine, olanzapine and quetiapine can be associated with cardiovascular and metabolic risks and poisoning, making them highly relevant in toxicological investigations. Since antipsyc...
Artificial Intelligence (AI): Some fundamentals to know its place and potential in forensic toxicology [0.03%]
论人工智能在法医毒物学中的地位与潜力：基础知识概要
Brigitte Desharnais,Tyler Devincenzi
Brigitte Desharnais
Anticholinergic toxidrome in a toddler with unwitnessed ingestion: Diagnostic clues pointing to over-the-counter medication overdose [0.03%]
幼儿未目睹摄入抗胆碱能药物中毒的诊断线索：指向非处方药过量的诊断线索
Sayaka Nagasawa,Go Inokuchi,Haruna Tokitomo et al.
Sayaka Nagasawa et al.
We report a case of a previously healthy 3-year-old girl who developed acute altered consciousness, agitation, and visual hallucinations consistent with an anticholinergic toxidrome. Initial examinations were unremarkable, and urine immunoa...
Simultaneous Quantification of Ceramides and Sphingosine-1-Phosphate in Serum by LC-MS/MS with Application to Alcohol Intoxication Cases [0.03%]
基于LC-MS/MS同时量化血清中的固醇胺和鞘氨醇-1-磷酸及其在醉酒案例中的应用
Yaqin Niu,Jingjing Cui,Lingjie Mo et al.
Yaqin Niu et al.
Ceramides and sphingosine-1-phosphate (S1P) are bioactive sphingolipids critically involved in the regulation of cell survival and death, whose homeostasis is disrupted by alcohol exposure. A liquid chromatography-tandem mass spectrometry (...