High-impact Genetic Variants in EGLN1, EPAS1, and Other Genes Identified in Mountaineers by Exome Sequencing [0.03%]
通过外显子组测序鉴定的高山运动员EGLN1、EPAS1和其他基因中的高影响遗传变异
Evgeniia M Maksiutenko,Valeriia А Merkureva,Yury A Barbitoff et al.
Evgeniia M Maksiutenko et al.
Background: Investigating the genetic basis of adaptation to environmental stresses, such as hypoxia, can enhance our understanding of human biology and resilience. High-altitude adaptation provides a valuable model for s...
Review of Potential Diagnostic and Therapeutic Developments in Systemic Lupus Erythematosus (SLE) [0.03%]
系统性红斑狼疮(SLE)潜在诊疗进展评述
Alexander Blagov,Vladislav Kalmykov,Alikhan Asoyan et al.
Alexander Blagov et al.
Systemic lupus erythematosus (SLE), a complex autoimmune disease, affects multiple tissues and organs, presenting substantial challenges for both diagnosis and treatment. Both innate and adaptive immune cells are involved in the intricate p...
The Genetic Feasibility of Gonadal Development and Fertility in Polyodon-Acipenserid Interfamilial Hybrids: An Opinion on the Chromosomal Basis [0.03%]
硬骨鱼科有性杂交鱼卵发生成熟和繁殖的遗传可行性的意见及染色体基础
Jenő Káldy,Gyula Kovács,Katalin Bogár et al.
Jenő Káldy et al.
Interfamilial hybridization between American paddlefish (Polyodon spathula) and Acipenserid (sturgeon) species produces viable hybrid offspring. However, the potential fertility of these hybrids is a critical issue for understanding sex det...
Glut1 Acts in Corazonin-Producing Neurons to Regulate Glycogen Storage in Drosophila [0.03%]
谷胱甘肽1通过果蝇黑皮质素能神经元调节糖原的储存
Prem Patel,Justin R DiAngelo
Prem Patel
Background: Metabolic homeostasis is regulated by numerous genes, whose dysregulation leads to metabolic diseases such as obesity and diabetes. Several genes important for lipid storage were identified in a buoyancy-based...
The Evaluation of Neurotrophic Receptor Tyrosine Kinase (NTRK) Alterations in Neuroblastomas [0.03%]
神经母细胞瘤中神经营养因子受体酪氨酸激酶(NTRK)改变的评估
Nuriya Ismayil,Sefayi Merve Özdemir,Tekincan Çağrı Aktaş et al.
Nuriya Ismayil et al.
Background: Neuroblastoma (NB) is the most common extracranial solid tumor among pediatric cancers and accounts for approximately 15% of childhood cancer-related deaths. Neurotrophic receptor tyrosine kinases (NTRKs) are ...
Molecular Characterization of the Epstein-Barr Virus in Malignant Tumors of Different Origins: An Emphasis on EBER Promoter Value for EBV Classification [0.03%]
EB病毒恶性肿瘤的分子特征及其启动子在EB病毒分类中的价值研究
Valerija Begić,Petra Šimičić,Kristian Bodulić et al.
Valerija Begić et al.
Background: Epstein-Barr virus (EBV) is a well-known cause of infectious mononucleosisand it has also been linked to the development of various malignant tumors. EBV can be classified into two genotypes based on EBNA-2 an...
Genomic Insights Into Developmental Language Disorders: Biomarkers and Their Interactions [0.03%]
基因组学视角下的发育性语言障碍研究：生物标志物及其交互作用分析
Rafal Adnan Hassan,Ali Al-Fatlawi
Rafal Adnan Hassan
Background: Developmental language disorders (DLDs) are common neurodevelopmental conditions, affecting approximately 7-10% of children, with significant impacts on communication, academic achievement, and social integrat...
Relationship Between Acinetobacter baumannii Pneumonia and Human CTLA4 Gene Polymorphism (rs231775) in Relation to IL-7 Serum Levels: A Study on Host-Pathogen Dynamics [0.03%]
关于鲍曼不动杆菌肺炎与宿主CTLA4基因多态性（rs231775）及IL-7血清水平关系的研完：探讨病原菌-宿主动态关系
Mayadah Mohammed Ridha Abdul-Razzaq,Wasan Abdul-Elah Bakir,Zainab Fadhel Ashoor et al.
Mayadah Mohammed Ridha Abdul-Razzaq et al.
Background: The relationship between genetic variations and susceptibility to infection provides insight into the pathogenesis of diseases caused by infections, illustrating host-pathogen interactions, informing preventiv...
Lucián Zastko
Lucián Zastko
DNA double-strand breaks (DSB) represent one of the most severe forms of genomic damage. Thus, cells have evolved a complex network of DSB repair pathways, including homologous recombination, classical and alternative end joining, and singl...
Uterine Fibroids-Associated GWAS Loci and the Risk of Arterial Hypertension: A Pilot Study [0.03%]
子宫肌瘤相关基因位点与高血压发病风险的关系研究试点项目
Liubov Ponomareva,Anna Dorofeeva,Julia Samoylenko et al.
Liubov Ponomareva et al.
Background: Uterine fibroids (UFs) are the most common benign tumors in women of reproductive age and are frequently associated with impaired fertility, reproductive dysfunction, and pregnancy complications. Arterial hype...