Nesfatin-1 Suppresses Inflammation in Bronchopulmonary Dysplasia by Regulating HMGB-1/TLR4/p65/NLRP3 Signaling Pathway [0.03%]
Nesfatin-1通过调节HMGB-1/TLR4/p65/NLRP3信号通路抑制支气管肺发育不良中的炎症反应
Xiaoting Yang,Gang Luo,Feifeng Lou
Xiaoting Yang
Background: Bronchopulmonary dysplasia (BPD) is a common respiratory disease in premature infants. Nesfatin-1 is considered for the treatment of BPD. This study aimed to explore the anti-inflammatory effect of nesfatin-1 ...
Docosahexaenoic Acid Attenuates Endoplasmic Reticulum Stress-Induced Neuron Apoptosis by Targeting Presenilin 2 [0.03%]
神经酰胺通过靶向早老素2抑制内质网应激诱导的神经元凋亡
Baojun Ma,Hanbin Ye,Gaoqiang Meng et al.
Baojun Ma et al.
Background: Traumatic neuronal injury (TNI), a type of traumatic brain injury (TBI), features apoptosis of cortical neurons. Knowing that docosahexaenoic acid (DHA) is enriched in the neuronal cell membranes and related t...
Investigation of Berberine's Cardioprotective Effects and Its Association With the Notch Signaling Pathway in Rat Myocardial Ischemia-Reperfusion Injury [0.03%]
小檗碱对大鼠心肌缺血再灌注损伤Notch信号通路的影响及 cardioprotective 作用机制研究
Daxing Jiang,Xin Tang,Haifan Yang et al.
Daxing Jiang et al.
Background: Ischemia-reperfusion injury poses a significant challenge in cardiac pathology, leading to myocardial cell damage and dysfunction. Berberine, a natural compound, has shown potential cardioprotective effects. T...
Complex Tissue Alterations After Socket Preservation With Demineralized Bone Matrix Binding With Growth Factors: A Study in the Beagle Dogs [0.03%]
脱矿骨基质与生长因子结合后保存术后的复杂组织改变：比格犬的研究
Bi-He Zhang,Jian-Hua Zhu,Tian-Cheng Qiu et al.
Bi-He Zhang et al.
Background: To study the hard tissue change after tooth extraction filled with demineralized bone matrix (DBM) collagen scaffold bound with growth factors. ...
Puerarin Inhibits the Development of Thyroid Cancer Through KLF2/NOTCH1 Signaling [0.03%]
葛根素通过KLF2/NRCHAT1信号抑制甲状腺癌的发展
Yanghong Zhou,Wei Li,Hong Huang
Yanghong Zhou
Background: Puerarin is the major bioactive ingredient extracted from Pueraria lobata. Puerarin has an antitumor effect on many kinds of cancer. Accordingly, the aim of this study was to investigate the effect and mechani...
Spermine Enhances Cholesterol Effluence of Macrophages Through Caspase 2-Mediated Autophagy [0.03%]
spermine通过半胱天冬酶2介导的自噬促进巨噬细胞胆固醇流出
Xinyue Yuan,Yifan Mao,Yuqiao Chen et al.
Xinyue Yuan et al.
Background: Spermine (SPM) is known to play a role in regulating cholesterol efflux of macrophages, which is a critical anti-atherosclerotic pathway, but the underlying mechanism remains elusive. The deficiency of caspase...
Investigating the Role of Ferroptosis in Soman-Induced Neurotoxicity: A Pathway to New Potential Therapeutic Targets [0.03%]
探究铁死亡在沙林诱导的神经毒性中的作用及潜在新治疗靶点的研究
Xiaosa Yang,Jiahua Zhao,Yuheng Shan et al.
Xiaosa Yang et al.
Background: Soman is a highly toxic organophosphorus nerve agent that can cause persistent neurotoxicity. However, the mechanism of soman-induced neurotoxicity has not been completely clarified. Ferroptosis, a novel type ...
Protective Effect of Resveratrol Against Peri-Implant Inflammation and Oxidative Stress: An in vivo Study [0.03%]
白藜芦醇对种植体周围炎的抗氧化作用及炎症保护作用：一项体内研究
Chao Zhang,Boqiang Jiao,Dajun Qian
Chao Zhang
Background: Implants are commonly used to repair teeth. However, with their widespread use, the incidence of peri-implantitis has also increased. The Mitogen activated protein kinase/Protein kinase B/Nuclear factor kappa-...
Mechanism Underlying Hyperbaric Oxygen's Effect on Nitric Oxide in an in Vitro Model of Traumatic Brain Injury [0.03%]
高压氧影响体外脑损伤模型中一氧化氮的机制研究
Quanming Zhou,Shejuan Wu,Hongzai Zhu
Quanming Zhou
Background: Hyperbaric oxygen (HBO) therapy functions as a possible therapeutic option for traumatic brain injury (TBI). The aim of this study is to detect the mechanism of HBO on TBI. ...
Glycyrrhizic Acid Ameliorates Sepsis-Induced Acute Lung Injury Through Suppression of Endoplasmic Reticulum Stress [0.03%]
甘草酸通过抑制内质网应激改善脓毒症诱导的急性肺损伤
Ling Fang,Xuepan Wang,Wei Guan
Ling Fang
Background: Sepsis-mediated acute lung injury (ALI) has a high mortality rate, and glycyrrhizic acid (GA) possesses diverse pharmacologic activities. Herein, we investigated the role of GA in attenuating sepsis-triggered ...