Robust, flexible, and scalable tests for Hardy-Weinberg equilibrium across diverse ancestries [0.03%]
稳健的、灵活的和可扩展的不同祖先的Hardy-Weinberg平衡检验方法
Alan M Kwong,Thomas W Blackwell,Jonathon LeFaive et al.
Alan M Kwong et al.
Traditional Hardy-Weinberg equilibrium (HWE) tests (the χ2 test and the exact test) have long been used as a metric for evaluating genotype quality, as technical artifacts leading to incorrect genotype calls often can be identified as devi...
Methods and tools for spatial mapping of single-cell RNAseq clusters in Drosophila [0.03%]
果蝇单细胞RNAseq聚类空间图谱的方法和工具研究
Stephanie E Mohr,Sudhir Gopal Tattikota,Jun Xu et al.
Stephanie E Mohr et al.
Single-cell RNA sequencing (scRNAseq) experiments provide a powerful means to identify clusters of cells that share common gene expression signatures. A major challenge in scRNAseq studies is to map the clusters to specific anatomical regio...
A novel allele of SIR2 reveals a heritable intermediate state of gene silencing [0.03%]
一个新的SIR2等位基因揭示了基因沉默的可以遗传的中间状态
Delaney Farris,Daniel S Saxton,Jasper Rine
Delaney Farris
Genetic information acquires additional meaning through epigenetic regulation, the process by which genetically identical cells can exhibit heritable differences in gene expression and phenotype. Inheritance of epigenetic information is a c...
Kuba Nowak,Paweł Błażej,Małgorzata Wnetrzak et al.
Kuba Nowak et al.
Reprogramming of the standard genetic code to include non-canonical amino acids (ncAAs) opens new prospects for medicine, industry, and biotechnology. There are several methods of code engineering, which allow us for storing new genetic inf...
X chromosome-dependent disruption of placental regulatory networks in hybrid dwarf hamsters [0.03%]
杂种侏儒仓鼠中X染色体依赖性的破坏胎盘调节网络
Thomas D Brekke,Emily C Moore,Shane C Campbell-Staton et al.
Thomas D Brekke et al.
Embryonic development in mammals is highly sensitive to changes in gene expression within the placenta. The placenta is also highly enriched for genes showing parent-of-origin or imprinted expression, which is predicted to evolve rapidly in...
Factors that influence bidirectional long-tract homozygosis due to double-strand break repair in Candida albicans [0.03%]
影响白念珠菌双链断裂修复过程中长片段双向同源重组的因素分析
Timea Marton,Murielle Chauvel,Adeline Feri et al.
Timea Marton et al.
Genomic rearrangements have been associated with the acquisition of adaptive phenotypes, allowing organisms to efficiently generate new favorable genetic combinations. The diploid genome of Candida albicans is highly plastic, displaying num...
Transcriptional Control of the Production of Aspergillus fumigatus Conidia-Borne Secondary Metabolite Fumiquinazoline C Important for Phagocytosis Protection [0.03%]
烟曲霉芽管次生代谢产物分泌的转录调控及其对胞内杀菌保护作用的影响机制研究
Marina Campos Rocha,João Henrique Tadini Marilhano Fabri,Lilian Pereira Silva et al.
Marina Campos Rocha et al.
Aspergillus fumigatus produces diverse secondary metabolites whose biological functions and regulation remain to be understood. Despite the importance of the conidia for this fungus, the role of the conidia-born metabolite fumiquinazoline C...
Functional impact of cancer-associated cohesin variants on gene expression and cellular identity [0.03%]
致癌共hes蛋白突变体对基因表达和细胞身份的功能影响
Natalie L Rittenhouse,Zachary M Carico,Ying Frances Liu et al.
Natalie L Rittenhouse et al.
Cohesin is a ring-shaped protein complex that controls dynamic chromosome structure. Cohesin activity is important for a variety of biological processes, including formation of DNA loops that regulate gene expression. The precise mechanisms...
Detecting de novo mitochondrial mutations in angiosperms with highly divergent evolutionary rates [0.03%]
识别被子植物中高度分化且进化速率不同的脱氧核糖核酸新突变
Amanda K Broz,Gus Waneka,Zhiqiang Wu et al.
Amanda K Broz et al.
Although plant mitochondrial genomes typically show low rates of sequence evolution, levels of divergence in certain angiosperm lineages suggest anomalously high mitochondrial mutation rates. However, de novo mutations have never been direc...
Masahiko Takemura,Nanako Bowden,Yi-Si Lu et al.
Masahiko Takemura et al.
The molecular mechanisms by which stem cell proliferation is precisely controlled during the course of regeneration are poorly understood. Namely, how a damaged tissue senses when to terminate the regeneration process, inactivates stem cell...