Turning coldspots into hotspots: targeted recruitment of axis protein Hop1 stimulates meiotic recombination in Saccharomyces cerevisiae [0.03%]
由冷点变热点：轴丝蛋白Hop1的靶向募集可促进模式真核生物酿酒酵母中的交换型重组
Anura Shodhan,Martin Xaver,David Wheeler et al.
Anura Shodhan et al.
The DNA double-strand breaks that initiate meiotic recombination are formed in the context of the meiotic chromosome axis, which in Saccharomyces cerevisiae contains a meiosis-specific cohesin isoform and the meiosis-specific proteins Hop1 ...
A distinct P-body-like granule is induced in response to the disruption of microtubule integrity in Saccharomyces cerevisiae [0.03%]
破坏微管结构可诱发明显的P体类似颗粒形成——以酿酒酵母为例研究非经典P体的形成机制
Zachary Hurst,Wenfang Liu,Qian Shi et al.
Zachary Hurst et al.
The Processing-body is a conserved membraneless organelle that has been implicated in the storage and/or decay of mRNAs. Although Processing-bodies have been shown to be induced by a variety of conditions, the mechanisms controlling their a...
A role for the Saccharomyces cerevisiae Rtt109 histone acetyltransferase in R-loop homeostasis and associated genome instability [0.03%]
酿酒酵母Rtt109组蛋白乙酰转移酶在R环稳态及相关的基因组不稳定性中的作用
Juan Carlos Cañas,María Luisa García-Rubio,Alicia García et al.
Juan Carlos Cañas et al.
The stability of the genome is occasionally challenged by the formation of DNA-RNA hybrids and R-loops, which can be influenced by the chromatin context. This is mainly due to the fact that DNA-RNA hybrids hamper the progression of replicat...
Octopaminergic/tyraminergic Tdc2 neurons regulate biased sperm usage in female Drosophila melanogaster [0.03%]
Tdc2神经元通过八胺/酪氨调节雄性小鼠偏好使用生殖细胞中的精子
Dawn S Chen,Andrew G Clark,Mariana F Wolfner
Dawn S Chen
In polyandrous internally fertilizing species, a multiply-mated female can use stored sperm from different males in a biased manner to fertilize her eggs. The female's ability to assess sperm quality and compatibility is essential for her r...
Hox genes collaborate with helix-loop-helix factor Grainyhead to promote neuroblast apoptosis along the anterior-posterior axis of the Drosophila larval central nervous system [0.03%]
咽侧体Hox基因和Grainyhead蛋白共同促进果蝇幼虫中枢神经系统沿头尾轴的神经前体细胞凋亡
Rashmi Sipani,Rohit Joshi
Rashmi Sipani
Hox genes code for a family of a homeodomain containing transcription factors that use TALE-HD containing factors Pbx/Exd and Meis/Homothorax to specify the development of the anterior-posterior axis of an organism. However, the absence of ...
The Caenorhabditis elegans ASPP homolog APE-1 is a junctional protein phosphatase 1 modulator [0.03%]
一种Caenorhabditis elegans ASPP同源物APE-1是衔接蛋白磷酸酶1的调节因子
Gwendolyn M Beacham,Derek T Wei,Erika Beyrent et al.
Gwendolyn M Beacham et al.
How serine/threonine phosphatases are spatially and temporally tuned by regulatory subunits is a fundamental question in cell biology. Ankyrin repeat, SH3 domain, proline-rich-region-containing proteins are protein phosphatase 1 catalytic s...
Estimating the rates of crossover and gene conversion from individual genomes [0.03%]
从个体基因组估计交叉和基因转换的速率
Derek Setter,Sam Ebdon,Ben Jackson et al.
Derek Setter et al.
Recombination can occur either as a result of crossover or gene conversion events. Population genetic methods for inferring the rate of recombination from patterns of linkage disequilibrium generally assume a simple model of recombination t...
Visualizing and quantifying molecular and cellular processes in Caenorhabditis elegans using light microscopy [0.03%]
采用光学显微镜在秀丽隐杆线虫中可视化及量化分子和细胞过程
Pavak Shah,Zhirong Bao,Ronen Zaidel-Bar
Pavak Shah
Light microscopes are the cell and developmental biologists' "best friend," providing a means to see structures and follow dynamics from the protein to the organism level. A huge advantage of Caenorhabditis elegans as a model organism is it...
The RNA-binding protein Swm is critical for Drosophila melanogaster intestinal progenitor cell maintenance [0.03%]
RNA结合蛋白Swm对于黑腹果蝇肠道干细胞的维持至关重要
Ishara S Ariyapala,Kasun Buddika,Heather A Hundley et al.
Ishara S Ariyapala et al.
The regulation of stem cell survival, self-renewal, and differentiation is critical for the maintenance of tissue homeostasis. Although the involvement of signaling pathways and transcriptional control mechanisms in stem cell regulation hav...
Altering enhancer-promoter linear distance impacts promoter competition in cis and in trans [0.03%]
增强子与启动子的线性距离变化会影响顺式和反式的启动子竞争
Jack R Bateman,Justine E Johnson
Jack R Bateman
In Drosophila, pairing of maternal and paternal homologs can permit trans-interactions between enhancers on one homolog and promoters on another, an example of a phenomenon called transvection. When chromosomes are paired, promoters in cis ...