Diploid-associated adaptation to chronic low-dose UV irradiation requires homologous recombination in Saccharomyces cerevisiae [0.03%]
端丝子酵母中二倍体相关的慢性低剂量紫外线照射适应需要同源重组
Mana Shibata,Kenji Keyamura,Takuya Shioiri et al.
Mana Shibata et al.
Ultraviolet-induced DNA lesions impede DNA replication and transcription and are therefore a potential source of genome instability. Here, we performed serial transfer experiments on nucleotide excision repair-deficient (rad14Δ) yeast cell...
Max Valentín Staller
Max Valentín Staller
Transcription factors regulate gene expression by binding to regulatory DNA and recruiting regulatory protein complexes. The DNA-binding and protein-binding functions of transcription factors are traditionally described as independent funct...
Roman Stetsenko,Denis Roze
Roman Stetsenko
Cytological data from flowering plants suggest that the evolution of recombination rates is affected by the mating system of organisms, as higher chiasma frequencies are often observed in self-fertilizing species compared with their outcros...
Genic and chromosomal components of Prdm9-driven hybrid male sterility in mice (Mus musculus) [0.03%]
驱动小鼠（Mus musculus）杂交雄性不育的基因和染色体成分PRDM9
Barbora Valiskova,Sona Gregorova,Diana Lustyk et al.
Barbora Valiskova et al.
Hybrid sterility contributes to speciation by preventing gene flow between related taxa. Prdm9, the first and only hybrid male sterility gene known in vertebrates, predetermines the sites of recombination between homologous chromosomes and ...
Multitrait Bayesian shrinkage and variable selection models with the BGLR-R package [0.03%]
多特征贝叶斯收缩与变量选择模型及其BGLR-R包实现
Paulino Pérez-Rodríguez,Gustavo de Los Campos
Paulino Pérez-Rodríguez
The BGLR-R package implements various types of single-trait shrinkage/variable selection Bayesian regressions. The package was first released in 2014, since then it has become a software very often used in genomic studies. We recently devel...
Selective disruption of Drp1-independent mitophagy and mitolysosome trafficking by an Alzheimer's disease relevant tau modification in a novel Caenorhabditis elegans model [0.03%]
tau修饰选择性地破坏线粒体自噬和溶酶体转运的细胞器通道：秀丽隐杆线虫模型研究阿尔茨海默病中的线粒体异常
Sanjib Guha,Anson Cheng,Trae Carroll et al.
Sanjib Guha et al.
Accumulation of inappropriately phosphorylated tau into neurofibrillary tangles is a defining feature of Alzheimer's disease, with Tau pT231 being an early harbinger of tau pathology. Previously, we demonstrated that expressing a single gen...
The DNA replication protein Orc1 from the yeast Torulaspora delbrueckii is required for heterochromatin formation but not as a silencer-binding protein [0.03%]
来自假丝酵母(Torulaspora delbrueckii)的DNA复制蛋白Orc1在异染色质形成中是必需的，但并不是一个沉默子结合蛋白
Haniam Maria,Laura N Rusche
Haniam Maria
To understand the process by which new protein functions emerge, we examined how the yeast heterochromatin protein Sir3 arose through gene duplication from the conserved DNA replication protein Orc1. Orc1 is a subunit of the origin recognit...
Beyond editing, CRISPR/Cas9 for protein localization: an educational primer for use with "A dCas9-based system identifies a central role for Ctf19 in kinetochore-derived suppression of meiotic recombination" [0.03%]
超越编辑，CRISPR / Cas9在蛋白质定位中的应用：兼作“基于dCas9系统的鉴定Ctf19在着丝粒区抑制同源重组中起核心作用”的教学参考文献
Shelby L McVey,Mischa A Olson,Wojciech P Pawlowski et al.
Shelby L McVey et al.
CRISPR/Cas9 has dramatically changed how we conduct genetic research, providing a tool for precise sequence editing. However, new applications of CRISPR/Cas9 have emerged that do not involve nuclease activity. In the accompanying article "A...
Transmembrane helices 5 and 12 control transport dynamics, substrate affinity, and specificity in the elevator-type UapA transporter [0.03%]
转运蛋白UapA的转运转机制及其底物亲和力和特异性的控制因素
Dimitris Dimakis,Yiannis Pyrris,George Diallinas
Dimitris Dimakis
An increasing number of solute transporters have been shown to function with the so-called sliding-elevator mechanism. Despite structural and functional differences, all elevator-type transporters use a common mechanism of substrate translo...
Imp and Syp mediated temporal patterning of neural stem cells in the developing Drosophila CNS [0.03%]
发育中的Drosophila中枢神经系统的Imp和Syp介导的神经干细胞的时间模式化
Ishrat Maliha Islam,Ted Erclik
Ishrat Maliha Islam
The assembly of complex neural circuits requires that stem cells generate diverse types of neurons in the correct temporal order. Pioneering work in the Drosophila embryonic ventral nerve cord has shown that neural stem cells are temporally...