Genome stability is guarded by yeast Rtt105 through multiple mechanisms [0.03%]
酵母Rtt105通过多种机制保护基因组稳定性
Yves Corda,Laetitia Maestroni,Pierre Luciano et al.
Yves Corda et al.
Ty1 mobile DNA element is the most abundant and mutagenic retrotransposon present in the genome of the budding yeast Saccharomyces cerevisiae. Protein regulator of Ty1 transposition 105 (Rtt105) associates with large subunit of RPA and faci...
Richard Gomulkiewicz,Micki L Thies,James J Bull
Richard Gomulkiewicz
Gene drives offer the possibility of altering and even suppressing wild populations of countless plant and animal species, and CRISPR technology now provides the technical feasibility of engineering them. However, population-suppression gen...
Comprehensive genetic analysis of adhesin proteins and their role in virulence of Candida albicans [0.03%]
白念珠菌粘附蛋白的全基因组分析及其在毒力中的作用
Sierra Rosiana,Liyang Zhang,Grace H Kim et al.
Sierra Rosiana et al.
Candida albicans is a microbial fungus that exists as a commensal member of the human microbiome and an opportunistic pathogen. Cell surface-associated adhesin proteins play a crucial role in C. albicans' ability to undergo cellular morphog...
Modulation of the complex regulatory network for methionine biosynthesis in fungi [0.03%]
调控真菌中复杂的甲硫氨酸生物合成调节网络
Manjari Shrivastava,Jinrong Feng,Mark Coles et al.
Manjari Shrivastava et al.
The assimilation of inorganic sulfate and the synthesis of the sulfur-containing amino acids methionine and cysteine is mediated by a multibranched biosynthetic pathway. We have investigated this circuitry in the fungal pathogen Candida alb...
The regulatory network for petal anthocyanin pigmentation is shaped by the MYB5a/NEGAN transcription factor in Mimulus [0.03%]
MYB5a/NEGAN转录因子塑造紫金牛属花瓣花青素色素调控网络
Xingyu Zheng,Kuenzang Om,Kimmy A Stanton et al.
Xingyu Zheng et al.
Much of the visual diversity of angiosperms is due to the frequent evolution of novel pigmentation patterns in flowers. The gene network responsible for anthocyanin pigmentation, in particular, has become a model for investigating how genet...
Additive genetic variance and covariance between relatives in synthetic wheat crosses with variable parental ploidy levels [0.03%]
具有不同亲本多倍体水平的合成小麦杂交中亲属间的加性基因变异和协方差
L E Puhl,J Crossa,S Munilla et al.
L E Puhl et al.
Cultivated bread wheat (Triticum aestivum L.) is an allohexaploid species resulting from the natural hybridization and chromosome doubling of allotetraploid durum wheat (T. turgidum) and a diploid goatgrass Aegilops tauschii Coss (Ae. tausc...
Genomic regions associated with microdeletion/microduplication syndromes exhibit extreme diversity of structural variation [0.03%]
与微缺失/微重复综合征相关的基因组区域表现出结构变异的极端多样性
Yulia Mostovoy,Feyza Yilmaz,Stephen K Chow et al.
Yulia Mostovoy et al.
Segmental duplications (SDs) are a class of long, repetitive DNA elements whose paralogs share a high level of sequence similarity with each other. SDs mediate chromosomal rearrangements that lead to structural variation in the general popu...
Inference of population genetic parameters from an irregular time series of seasonal influenza virus sequences [0.03%]
季节性流感病毒序列不规则时间序列的群体遗传参数推理
Myriam Croze,Yuseob Kim
Myriam Croze
Basic summary statistics that quantify the population genetic structure of influenza virus are important for understanding and inferring the evolutionary and epidemiological processes. However, the sampling dates of global virus sequences i...
Aging modulated by the Drosophila insulin receptor through distinct structure-defined mechanisms [0.03%]
果蝇胰岛素受体通过特定结构决定的机制调节衰老
Rochele Yamamoto,Michael Palmer,Helen Koski et al.
Rochele Yamamoto et al.
Mutations of the Drosophila melanogaster insulin/IGF signaling system slow aging, while also affecting growth and reproduction. To understand this pleiotropy, we produced an allelic series of single codon substitutions in the Drosophila ins...
A fish with no sex: gonadal and adrenal functions partition between zebrafish NR5A1 co-orthologs [0.03%]
一种无性别的鱼：斑马鱼NR5A1共同源基因在生殖腺和肾上腺中的功能分离
Yi-Lin Yan,Tom Titus,Thomas Desvignes et al.
Yi-Lin Yan et al.
People with NR5A1 mutations experience testicular dysgenesis, ovotestes, or adrenal insufficiency, but we do not completely understand the origin of this phenotypic diversity. NR5A1 is expressed in gonadal soma precursor cells before expres...