Microtubule-associated proteins and motors required for ectopic microtubule array formation in Saccharomyces cerevisiae [0.03%]
酿酒酵母胞质微管非典型排列形成所需要的微管结合蛋白和马达蛋白
Brianna R King,Janet B Meehl,Tamira Vojnar et al.
Brianna R King et al.
The mitotic spindle is resilient to perturbation due to the concerted, and sometimes redundant, action of motors and microtubule-associated proteins. Here, we utilize an inducible ectopic microtubule nucleation site in the nucleus of Saccha...
Reduced gene dosage of histone H4 prevents CENP-A mislocalization and chromosomal instability in Saccharomyces cerevisiae [0.03%]
组蛋白H4基因剂量降低可防止酿酒酵母中的CENP-A错定位和染色体不稳定
Jessica R Eisenstatt,Kentaro Ohkuni,Wei-Chun Au et al.
Jessica R Eisenstatt et al.
Mislocalization of the centromeric histone H3 variant (Cse4 in budding yeast, CID in flies, CENP-A in humans) to noncentromeric regions contributes to chromosomal instability (CIN) in yeast, fly, and human cells. Overexpression and mislocal...
Marco Lopez-Cruz,Gustavo de Los Campos
Marco Lopez-Cruz
Genomic prediction uses DNA sequences and phenotypes to predict genetic values. In homogeneous populations, theory indicates that the accuracy of genomic prediction increases with sample size. However, differences in allele frequencies and ...
De novo assembly and delivery to mouse cells of a 101 kb functional human gene [0.03%]
从头组装并递送一个功能性的101 kb人类基因至小鼠细胞中
Leslie A Mitchell,Laura H McCulloch,Sudarshan Pinglay et al.
Leslie A Mitchell et al.
Design and large-scale synthesis of DNA has been applied to the functional study of viral and microbial genomes. New and expanded technology development is required to unlock the transformative potential of such bottom-up approaches to the ...
Proteasome Control of [URE3] Prion Propagation by Degradation of Anti-Prion Proteins Cur1 and Btn2 in Saccharomyces cerevisiae [0.03%]
蛋白酶体通过降解抗-prion蛋白Cur1和Btn2控制[Ured]prion的传播作用机制研究
Herman K Edskes,Emily E Stroobant,Morgan P DeWilde et al.
Herman K Edskes et al.
[URE3] is a prion of the nitrogen catabolism controller, Ure2p, and [PSI+] is a prion of the translation termination factor Sup35p in S. cerevisiae. Btn2p cures [URE3] by sequestration of Ure2p amyloid filaments. Cur1p, paralogous to Btn2p,...
Morgane G Stum,Abigail L D Tadenev,Kevin L Seburn et al.
Morgane G Stum et al.
The final step in proline biosynthesis is catalyzed by three pyrroline-5-carboxylate reductases, PYCR1, PYCR2, and PYCR3, which convert pyrroline-5-carboxylate (P5C) to proline. Mutations in human PYCR1 and ALDH18A1 (P5C Synthetase) cause C...
Genetic variation in aneuploidy prevalence and tolerance across Saccharomyces cerevisiae lineages [0.03%]
酿酒酵母染体数异常变异频率和耐受性的遗传差异
Eduardo F C Scopel,James Hose,Douda Bensasson et al.
Eduardo F C Scopel et al.
Individuals carrying an aberrant number of chromosomes can vary widely in their expression of aneuploidy phenotypes. A major unanswered question is the degree to which an individual's genetic makeup influences its tolerance of karyotypic im...
Leveraging the cell lineage to predict cell-type specificity of regulatory variation from bulk genomics [0.03%]
利用细胞谱系从批量基因组学预测调控变异的细胞类型特异性
Gal Yankovitz,Ofir Cohn,Eran Bacharach et al.
Gal Yankovitz et al.
Recent computational methods have enabled the inference of the cell-type-specificity of eQTLs based on bulk transcriptomes from highly heterogeneous tissues. However, these methods are limited in their scalability to highly heterogeneous ti...
Why genetic selection to reduce the prevalence of infectious diseases is way more promising than currently believed [0.03%]
为什么通过基因选择来减少传染病流行率的前景比目前认为的要好得多
Andries D Hulst,Mart C M de Jong,Piter Bijma
Andries D Hulst
Genetic selection for improved disease resistance is an important part of strategies to combat infectious diseases in agriculture. Quantitative genetic analyses of binary disease status, however, indicate low heritability for most diseases,...
Showcasing Fungal Genetics & Genomics with the Genetics Society of America [0.03%]
美国遗传学会展示真菌遗传学及基因组学研究进展
Leah E Cowen,Joseph Heitman
Leah E Cowen