Ghost QTL and hotspots in experimental crosses: novel approach for modeling polygenic effects [0.03%]
实验杂交中的幽灵QTL和热点：建模多基因效应的新方法
Jonas Wallin,Małgorzata Bogdan,Piotr A Szulc et al.
Jonas Wallin et al.
Ghost quantitative trait loci (QTL) are the false discoveries in QTL mapping, that arise due to the "accumulation" of the polygenic effects, uniformly distributed over the genome. The locations on the chromosome that are strongly correlated...
The timing of human adaptation from Neanderthal introgression [0.03%]
尼安德特人基因 introgression 的时间及其对人类适应的影响
Sivan Yair,Kristin M Lee,Graham Coop
Sivan Yair
Admixture has the potential to facilitate adaptation by providing alleles that are immediately adaptive in a new environment or by simply increasing the long-term reservoir of genetic diversity for future adaptation. A growing number of cas...
A novel allele of the Arabidopsis thaliana MACPF protein CAD1 results in deregulated immune signaling [0.03%]
拟南芥MACPF蛋白CAD1的新等位基因导致免疫信号失调
Danalyn R Holmes,Melissa Bredow,Kathrin Thor et al.
Danalyn R Holmes et al.
Immune recognition in plants is governed by two major classes of receptors: pattern recognition receptors (PRRs) and nucleotide-binding leucine-rich repeat receptors (NLRs). Located at the cell surface, PRRs bind extracellular ligands origi...
Scarless engineering of the Drosophila genome near any site-specific integration site [0.03%]
在特定位点附近进行无痕的果蝇基因组工程改造
Siqian Feng,Shan Lu,Wesley B Grueber et al.
Siqian Feng et al.
We describe a simple and efficient technique that allows scarless engineering of Drosophila genomic sequences near any landing site containing an inverted attP cassette, such as a MiMIC insertion. This two-step method combines phiC31 integr...
Assessing the performance of qpAdm: a statistical tool for studying population admixture [0.03%]
评估qpAdm性能：一种研究人群混合的统计工具
Éadaoin Harney,Nick Patterson,David Reich et al.
Éadaoin Harney et al.
qpAdm is a statistical tool for studying the ancestry of populations with histories that involve admixture between two or more source populations. Using qpAdm, it is possible to identify plausible models of admixture that fit the population...
Automated and customizable quantitative image analysis of whole Caenorhabditis elegans germlines [0.03%]
全自动且可定制的整个秀丽隐杆线虫生殖系的定量图像分析
Erik Toraason,Victoria L Adler,Nicole A Kurhanewicz et al.
Erik Toraason et al.
Arranged in a spatial-temporal gradient for germ cell development, the adult germline of Caenorhabditis elegans is an excellent system for understanding the generation, differentiation, function, and maintenance of germ cells. Imaging whole...
Per Sjödin,James McKenna,Mattias Jakobsson
Per Sjödin
The patterns of genetic variation within and among individuals and populations can be used to make inferences about the evolutionary forces that generated those patterns. Numerous population genetic approaches have been developed in order t...
Clade-specific chromosomal rearrangements and loss of subtelomeric adhesins in Candida auris [0.03%]
芽生菌属auris基因组中门特有染色体重组及亚端粒粘附蛋白丢失现象
José F Muñoz,Rory M Welsh,Terrance Shea et al.
José F Muñoz et al.
Candida auris is an emerging fungal pathogen of rising concern due to global spread, the ability to cause healthcare-associated outbreaks, and antifungal resistance. Genomic analyses revealed that early contemporaneously detected cases of C...
Detecting sex-linked genes using genotyped individuals sampled in natural populations [0.03%]
利用自然群体中基因分型个体检测伴性遗传基因
Jos Käfer,Nicolas Lartillot,Gabriel A B Marais et al.
Jos Käfer et al.
We propose a method, SDpop, able to infer sex-linkage caused by recombination suppression typical of sex chromosomes. The method is based on the modeling of the allele and genotype frequencies of individuals of known sex in natural populati...
miR-71 mediates age-dependent opposing contributions of the stress-activated kinase KGB-1 in Caenorhabditis elegans [0.03%]
秀丽隐杆线虫中应激激活激酶KGB-1介导的年龄依赖性相反贡献的调节机制
Cyrus Ruediger,Siavash Karimzadegan,Sonya Lin et al.
Cyrus Ruediger et al.
Studying the evolutionary processes that shaped aging offers a path for understanding the causes of aging. The antagonistic pleiotropy theory for the evolution of aging proposes that the inverse correlation between age and natural selection...