Complex genetics cause and constrain fungal persistence in different parts of the mammalian body [0.03%]
复杂的遗传机制导致和限制了真菌在哺乳动物身体不同部位的持久性
Martin N Mullis,Caleb Ghione,Michael Lough-Stevens et al.
Martin N Mullis et al.
Determining how genetic polymorphisms enable certain fungi to persist in mammalian hosts can improve understanding of opportunistic fungal pathogenesis, a source of substantial human morbidity and mortality. We examined the genetic basis of...
3D chromatin structure in chondrocytes identifies putative osteoarthritis risk genes [0.03%]
软骨细胞中的三维染色体结构确定了潜在的骨关节炎风险基因
Eliza Thulson,Eric S Davis,Susan D&#x;Costa et al.
Eliza Thulson et al.
Genome-wide association studies have identified over 100 loci associated with osteoarthritis risk, but the majority of osteoarthritis risk variants are noncoding, making it difficult to identify the impacted genes for further study and ther...
Spatial structure alters the site frequency spectrum produced by hitchhiking [0.03%]
空间结构改变了伴连选择产生的位点频率谱
Jiseon Min,Misha Gupta,Michael M Desai et al.
Jiseon Min et al.
The reduction of genetic diversity due to genetic hitchhiking is widely used to find past selective sweeps from sequencing data, but very little is known about how spatial structure affects hitchhiking. We use mathematical modeling and simu...
Developmental history modulates adult olfactory behavioral preferences via regulation of chemoreceptor expression in Caenorhabditiselegans [0.03%]
线虫通过调控嗅觉受体表达调节发育史对成年期行为偏好的影响
Travis Kyani-Rogers,Alison Philbrook,Ian G McLachlan et al.
Travis Kyani-Rogers et al.
Developmental experiences play critical roles in shaping adult physiology and behavior. We and others previously showed that adult Caenorhabditiselegans which transiently experienced dauer arrest during development (postdauer) exhibit disti...
Marker-assisted mapping enables forward genetic analysis in Aedes aegypti, an arboviral vector with vast recombination deserts [0.03%]
标记辅助定位使Aedes aegypti（一种携带大量重组沙漠的节肢动物病毒载体）的正向遗传分析成为可能
Chujia Chen,Austin Compton,Katerina Nikolouli et al.
Chujia Chen et al.
Aedes aegypti is a major vector of arboviruses that cause dengue, chikungunya, yellow fever, and Zika. Although recent success in reverse genetics has facilitated rapid progress in basic and applied research, integration of forward genetics...
A balancing act: interactions within NuA4/TIP60 regulate picNuA4 function in Saccharomyces cerevisiae and humans [0.03%]
picNuA4的平衡术：在酿酒酵母和人类中NuA4/TIP60相互作用调控picNuA4的功能
Phoebe Y T Lu,Alyssa C Kirlin,Maria J Aristizabal et al.
Phoebe Y T Lu et al.
The NuA4 lysine acetyltransferase complex acetylates histone and nonhistone proteins and functions in transcription regulation, cell cycle progression, and DNA repair. NuA4 harbors an interesting duality in that its catalytic module can fun...
Identification of genetic mechanisms for tissue-specific genetic effects based on CRISPR screens [0.03%]
基于CRISPR筛选鉴定组织特异性遗传效应的遗传机制
Elad Dvir,Shahar Shohat,Jonathan Flint et al.
Elad Dvir et al.
A major challenge in genetic studies of complex diseases is to determine how the action of risk genes is restricted to a tissue or cell type. Here, we investigate tissue specificity of gene action using CRISPR screens from 786 cancer cell l...
Nonidentical function of Upc2A binding sites in the Candida glabrata CDR1 promoter [0.03%]
Upc2A结合位点在酿酒念珠菌CDR1启动子中的非同一功能研究
Bao Gia Vu,William Scott Moye-Rowley
Bao Gia Vu
Increased expression of the Candida glabrata CDR1 gene, encoding an ATP-binding cassette membrane transporter, is routinely observed in fluconazole-resistant isolates of this pathogenic yeast. CDR1 transcription has been well-documented to ...
Genetic analysis of human RNA binding motif protein 48 (RBM48) reveals an essential role in U12-type intron splicing [0.03%]
人RNA结合基序蛋白48（RBM48）的遗传分析揭示了其在U12型内含子剪接中的重要作用
Amy E Siebert,Jacob Corll,J Paige Gronevelt et al.
Amy E Siebert et al.
U12-type or minor introns are found in most multicellular eukaryotes and constitute ∼0.5% of all introns in species with a minor spliceosome. Although the biological significance for the evolutionary conservation of U12-type introns is deb...
A reciprocal translocation involving Aspergillus nidulans snxAHrb1/Gbp2 and gyfA uncovers a new regulator of the G2-M transition and reveals a role in transcriptional repression for the setBSet2 histone H3-lysine-36 methyltransferase [0.03%]
牵涉曲霉snxahrb1/gbp2和gyfa的互惠易位揭示了G2-M转换的新调节因子，并且发现setbset2组蛋白H3-赖氨酸36甲基转移酶在转录抑制中的作用
Steven W James,Jonathan Palmer,Nancy P Keller et al.
Steven W James et al.
Aspergillus nidulans snxA, an ortholog of Saccharomyces cerevisiae Hrb1/Gbp2 messenger RNA shuttle proteins, is-in contrast to budding yeast-involved in cell cycle regulation, in which snxA1 and snxA2 mutations as well as a snxA deletion sp...