Conserved and divergent aspects of Robo receptor signaling and regulation between Drosophila Robo1 and C. elegans SAX-3 [0.03%]
果蝇Robo1和秀丽隐杆线虫SAX-3间Robo受体信号转导及调节的保守性与分歧性方面的问题研究进展
Trent Daiber,Christine J VanderZwan-Butler,Greg J Bashaw et al.
Trent Daiber et al.
The evolutionarily conserved Roundabout (Robo) family of axon guidance receptors control midline crossing of axons in response to the midline repellant ligand Slit in bilaterian animals including insects, nematodes, and vertebrates. Despite...
Krisna Van Dyke,Sheila Lutz,Gemechu Mekonnen et al.
Krisna Van Dyke et al.
Gene expression differences among individuals are shaped by trans-acting expression quantitative trait loci (eQTLs). Most trans-eQTLs map to hotspot locations that influence many genes. The molecular mechanisms perturbed by hotspots are oft...
Translating insights from the seed metabolome into improved prediction for lipid-composition traits in oat (Avena sativa L.) [0.03%]
利用种子代谢组学知识提高燕麦（Avena sativa L.）脂质组成性状预测准确性
Malachy T Campbell,Haixiao Hu,Trevor H Yeats et al.
Malachy T Campbell et al.
Oat (Avena sativa L.) seed is a rich resource of beneficial lipids, soluble fiber, protein, and antioxidants, and is considered a healthful food for humans. Little is known regarding the genetic controllers of variation for these compounds ...
Specific collagens maintain the cuticle permeability barrier in Caenorhabditis elegans [0.03%]
特定胶原蛋白维持秀丽隐杆线虫角质层的渗透屏障功能
Anjali Sandhu,Divakar Badal,Riya Sheokand et al.
Anjali Sandhu et al.
Collagen-enriched cuticle forms the outermost layer of skin in nematode Caenorhabditis elegans. The nematode's genome encodes 177 collagens, but little is known about their role in maintaining the structure or barrier function of the cuticl...
Disrupting progression of the yeast Hsp90 folding pathway at different transition points results in client-specific maturation defects [0.03%]
在酵母Hsp90折叠途径的不同过渡点干扰会产生特定底物的成熟缺陷
Kaitlyn Hohrman,Davi Gonçalves,Kevin A Morano et al.
Kaitlyn Hohrman et al.
The protein molecular chaperone Hsp90 (Heat shock protein, 90 kilodalton) plays multiple roles in the biogenesis and regulation of client proteins impacting myriad aspects of cellular physiology. Amino acid alterations located throughout Sa...
Natural genetic variation in Drosophila melanogaster reveals genes associated with Coxiella burnetii infection [0.03%]
利用自然遗传变异发现果蝇黑腹幼虫与贝纳氏库克斯体感染有关的基因
Rosa M Guzman,Zachary P Howard,Ziying Liu et al.
Rosa M Guzman et al.
The gram-negative bacterium Coxiella burnetii is the causative agent of Query (Q) fever in humans and coxiellosis in livestock. Host genetics are associated with C. burnetii pathogenesis both in humans and animals; however, it remains unkno...
Robust modeling of additive and nonadditive variation with intuitive inclusion of expert knowledge [0.03%]
稳健地建模加性和非加性变异并直观地包含专家知识
Ingeborg Gullikstad Hem,Maria Lie Selle,Gregor Gorjanc et al.
Ingeborg Gullikstad Hem et al.
We propose a novel Bayesian approach that robustifies genomic modeling by leveraging expert knowledge (EK) through prior distributions. The central component is the hierarchical decomposition of phenotypic variation into additive and nonadd...
The genetic architecture of human complex phenotypes is modulated by linkage disequilibrium and heterozygosity [0.03%]
链锁不平衡和杂合度影响人类复杂性状的遗传结构
Dominic Holland,Oleksandr Frei,Rahul Desikan et al.
Dominic Holland et al.
We propose an extended Gaussian mixture model for the distribution of causal effects of common single nucleotide polymorphisms (SNPs) for human complex phenotypes that depends on linkage disequilibrium (LD) and heterozygosity (H), while als...
Adaptive gene misregulation [0.03%]
适应性基因表达失调
Andreas Wagner
Andreas Wagner
Because gene expression is important for evolutionary adaptation, its misregulation is an important cause of maladaptation. A misregulated gene can be incorrectly silent ("off") when a transcription factor (TF) that is required for its acti...
Architectural Mediator subunits are differentially essential for global transcription in Saccharomyces cerevisiae [0.03%]
模式中介互作因子亚基在酿酒酵母全基因组转录调控中具有不同的重要性
Jason P Tourigny,Kenny Schumacher,Moustafa M Saleh et al.
Jason P Tourigny et al.
Mediator is a modular coactivator complex involved in the transcription of the majority of RNA polymerase II-regulated genes. However, the degrees to which individual core subunits of Mediator contribute to its activity have been unclear. H...