Ion transport peptide regulates energy intake, expenditure, and metabolic homeostasis in Drosophila [0.03%]
离子转运肽通过调节能量消耗和代谢稳态来调控能量摄入以适应营养变化——果蝇中的研究
Martina Gáliková,Peter Klepsatel
Martina Gáliková
In mammals, energy homeostasis is regulated by the antagonistic action of hormones insulin and glucagon. However, in contrast to the highly conserved insulin, glucagon is absent in most invertebrates. Although there are several endocrine re...
Graham Gower,Aaron P Ragsdale,Gertjan Bisschop et al.
Graham Gower et al.
Understanding the demographic history of populations is a key goal in population genetics, and with improving methods and data, ever more complex models are being proposed and tested. Demographic models of current interest typically consist...
Estimation of site frequency spectra from low-coverage sequencing data using stochastic EM reduces overfitting, runtime, and memory usage [0.03%]
利用随机EM从低覆盖率测序数据估计位点频率光谱可减少过拟合、运行时间和内存使用
Malthe Sebro Rasmussen,Genís Garcia-Erill,Thorfinn Sand Korneliussen et al.
Malthe Sebro Rasmussen et al.
The site frequency spectrum is an important summary statistic in population genetics used for inference on demographic history and selection. However, estimation of the site frequency spectrum from called genotypes introduces bias when work...
BMI-CNV: a Bayesian framework for multiple genotyping platforms detection of copy number variants [0.03%]
基于多种基因分型平台的拷贝数变异检测的Bayesian框架 BMI-CNV
Xizhi Luo,Guoshuai Cai,Alexander C Mclain et al.
Xizhi Luo et al.
Whole-exome sequencing (WES) enables the detection of copy number variants (CNVs) with high resolution in protein-coding regions. However, variants in the intergenic or intragenic regions are excluded from studies. Fortunately, many of thes...
Intrinsic base substitution patterns in diverse species reveal links to cancer and metabolism [0.03%]
来自不同物种的内在碱基替换模式揭示了与癌症和代谢之间的联系
Suzana P Gelova,Kassidy N Doherty,Salma Alasmar et al.
Suzana P Gelova et al.
Analyses of large-scale cancer sequencing data have revealed that mutagenic processes can create distinctive patterns of base substitutions, called mutational signatures. Interestingly, mutational patterns resembling some of these signature...
Su(var)2-10- and Su(var)205-dependent upregulation of the heterochromatic gene neverland is required for developmental transition in Drosophila [0.03%]
苏共(var)2-10和苏共(var)205依赖的异染色质基因neverland上调是果蝇发育转换所必需的
Yuya Ohhara,Yuki Kato,Takumi Kamiyama et al.
Yuya Ohhara et al.
Animals develop from juveniles to sexually mature adults through the action of steroid hormones. In insect metamorphosis, a surge of the steroid hormone ecdysone prompts the transition from the larval to the adult stage. Ecdysone is synthes...
Spalt and disco define the dorsal-ventral neuroepithelial compartments of the developing Drosophila medulla [0.03%]
Spalt和Disco定义了发育中的Drosophila medulla的背腹神经上皮区室
Priscilla Valentino,Ted Erclik
Priscilla Valentino
Spatial patterning of neural stem cell populations is a powerful mechanism by which to generate neuronal diversity. In the developing Drosophila medulla, the symmetrically dividing neuroepithelial cells of the outer proliferation center cre...
Rapid large-scale genomic introgression in Arabidopsis suecica via an autoallohexaploid bridge [0.03%]
拟南芥属进化中的快速大范围基因组引进事件及自异六倍体桥梁的作用
Vidya Oruganti,Helena Toegelová,Aleš Pečinka et al.
Vidya Oruganti et al.
Gene flow between species in the genus Arabidopsis occurs in significant amounts, but how exactly gene flow is achieved is not well understood. Polyploidization may be one avenue to explain gene flow between species. One problem, however, w...
Sharu Paul Sharma,Thomas Peterson
Sharu Paul Sharma
Eukaryotic genomes are large and complex, and gene expression can be affected by multiple regulatory elements and their positions within the dynamic chromatin architecture. Transposable elements are known to play important roles in genome e...
Archetypes of inflorescence: genome-wide association networks of panicle morphometric, growth, and disease variables in a multiparent oat population [0.03%]
基于多亲本燕麦群体的分蘖花序表型全基因组关联网络及重要位点鉴定
Craig H Carlson,Jason D Fiedler,Sepehr Mohajeri Naraghi et al.
Craig H Carlson et al.
There is limited information regarding the morphometric relationships of panicle traits in oat (Avena sativa) and their contribution to phenology and growth, physiology, and pathology traits important for yield. To model panicle growth and ...