Opening up Peer Review [0.03%]
开放同行评审
Tracey A DePellegrin,Mark Johnston
Tracey A DePellegrin
Genetic determinants of polygenic prediction accuracy within a population [0.03%]
群体内多基因预测准确性的遗传决定因素
Tianyuan Lu,Vincenzo Forgetta,John Brent Richards et al.
Tianyuan Lu et al.
Genomic risk prediction is on the emerging path toward personalized medicine. However, the accuracy of polygenic prediction varies strongly in different individuals. Based on up to 352,277 European ancestry participants in the UK Biobank, w...
Bacterial Hsp90 predominantly buffers but does not potentiate the phenotypic effects of deleterious mutations during fluorescent protein evolution [0.03%]
细菌Hsp90在荧光蛋白进化过程中主要缓冲但并不增强不利突变的表型效应
Bharat Ravi Iyengar,Andreas Wagner
Bharat Ravi Iyengar
Chaperones facilitate the folding of other ("client") proteins and can thus affect the adaptive evolution of these clients. Specifically, chaperones affect the phenotype of proteins via two opposing mechanisms. On the one hand, they can buf...
Network regression analysis for binary and ordinal categorical phenotypes in transcriptome-wide association studies [0.03%]
转录组关联研究中二元和有序分类表型的网络回归分析
Liye Zhang,Tao Ju,Xiuyuan Jin et al.
Liye Zhang et al.
Transcriptome-wide association studies aim to integrate genome-wide association studies and expression quantitative trait loci mapping studies for exploring the gene regulatory mechanisms underlying diseases. Existing transcriptome-wide ass...
Saif Hossain,Nicole Robbins,Leah E Cowen
Saif Hossain
Candida albicans is an opportunistic fungal pathogen that causes superficial infections in immunocompetent individuals, as well as life-threatening systemic disease in immunocompromised patients. A key virulence trait of this pathogen is it...
Multiple origins, one evolutionary trajectory: gradual evolution characterizes distinct lineages of allotetraploid Brachypodium [0.03%]
多重起源，单一进化轨迹自交同源四倍体Brachypodium的渐进式进化特征
Virginia T Scarlett,John T Lovell,Mingqin Shao et al.
Virginia T Scarlett et al.
The "genomic shock" hypothesis posits that unusual challenges to genome integrity such as whole genome duplication may induce chaotic genome restructuring. Decades of research on polyploid genomes have revealed that this is often, but not a...
Conserved roles for Hnf4 family transcription factors in zebrafish development and intestinal function [0.03%]
Hnf4家族转录因子在斑马鱼发育和肠功能中的保守作用
Jennifer K Heppert,Colin R Lickwar,Matthew C Tillman et al.
Jennifer K Heppert et al.
Transcription factors play important roles in the development of the intestinal epithelium and its ability to respond to endocrine, nutritional, and microbial signals. Hepatocyte nuclear factor 4 family nuclear receptors are liganded transc...
Gattaca as a lens on contemporary genetics: marking 25 years into the film's "not-too-distant" future [0.03%]
Gattaca：透视当代遗传学 电影设定的“不远将来”已过去25年了
C Brandon Ogbunugafor,Michael D Edge
C Brandon Ogbunugafor
The 1997 film Gattaca has emerged as a canonical pop culture reference used to discuss modern controversies in genetics and bioethics. It appeared in theaters a few years prior to the announcement of the "completion" of the human genome (20...
The contribution of sex chromosome conflict to disrupted spermatogenesis in hybrid house mice [0.03%]
性染色体冲突对杂种小家鼠精子发生紊乱的贡献
Emily E K Kopania,Eleanor M Watson,Claudia C Rathje et al.
Emily E K Kopania et al.
Incompatibilities on the sex chromosomes are important in the evolution of hybrid male sterility, but the evolutionary forces underlying this phenomenon are unclear. House mice (Mus musculus) lineages have provided powerful models for under...